- Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells
[作者:Kim, JH; Kononenko, A; Erliandri, I; Kim, TA; Nakano, M; Iida, Y; Barrett, JC; Oshimura, M; Masumoto, H; Earnshaw, WC; Larionov, V; Kouprina, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20048-20053 , 文章类型: Article,,卷期:2011年108-50]
- Human artificial chromosome (HAC)-based vectors offer a promising system for delivery and expression of full-length human genes of any size. HACs avoid the limited cloning capacity, lack of copy number control, and inser...
- T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling
[作者:Germar, K; Dose, M; Konstantinou, T; Zhang, JW; Wang, HF; Lobry, C; Arnett, KL; Blacklow, SC; Aifantis, I; Aster, JC; Gounari, F,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20060-20065 , 文章类型: Article,,卷期:2011年108-50]
- Although transcriptional programs associated with T-cell specification and commitment have been described, the functional hierarchy and the roles of key regulators in structuring/orchestrating these programs remain uncle...
- Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation
[作者:Glanville, J; Kuo, TC; von Budingen, HC; Guey, L; Berka, J; Sundar, PD; Huerta, G; Mehta, GR; Oksenberg, JR; Hauser, SL; Cox, DR; Rajpal, A; Pons, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20066-20071 , 文章类型: Article,,卷期:2011年108-50]
- A diverse antibody repertoire is essential for an effective adaptive immune response to novel molecular surfaces. Although past studies have observed common patterns of V-segment use, as well as variation in V-segment us...
- Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2 beta
[作者:Cai, XJ; Srivastava, S; Sun, Y; Li, Z; Wu, HY; Zuvela-Jelaska, L; Li, J; Salamon, RS; Backer, JM; Skolnik, EY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20072-20077 , 文章类型: Article,,卷期:2011年108-50]
- The K(+) channel KCa3.1 is required for Ca(2+) influx and the subsequent activation of CD4 T cells. The class II phosphatidylinositol 3 kinase C2 beta (PI3KC2 beta) is activated by the T-cell receptor (TCR) and is critic...
- Mechanistic modeling of the effects of myoferlin on tumor cell invasion
[作者:Eisenberg, MC; Kim, Y; Li, R; Ackerman, WE; Kniss, DA; Friedman, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20078-20083 , 文章类型: Article,,卷期:2011年108-50]
- Myoferlin (MYOF) is a member of the evolutionarily conserved ferlin family of proteins, noted for their role in a variety of membrane processes, including endocytosis, repair, and vesicular transport. Notably, ferlins ar...
- Geographical analysis of the role of water supply and sanitation in the risk of helminth infections of children in West Africa
[作者:Magalhaes, RJS; Barnett, AG; Clements, ACA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20084-20089 , 文章类型: Article,,卷期:2011年108-50]
- Globally, inadequate water supply, sanitation, and hygiene (WASH) are major contributors to mortality and burden of disease. We aimed to quantify the role of WASH in the risk of Schistosoma hematobium, Schistosoma manson...
- Estrogen receptor beta and 17 beta-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer
[作者:Muthusamy, S; Andersson, S; Kim, HJ; Butler, R; Waage, L; Bergerheim, U; Gustafsson, JA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20090-20094 , 文章类型: Article,,卷期:2011年108-50]
- Estrogen receptor beta (ER beta) is activated in the prostate by 5 alpha-androstane-3 beta, 17 beta-diol (3 beta-Adiol) where it exerts antiproliferative activity. The proliferative action of the androgen receptor is act...
- Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response
[作者:Malik, AF; Hoque, R; Ouyang, XS; Ghani, A; Hong, EP; Khan, K; Moore, LB; Ng, G; Munro, F; Flavell, RA; Shi, Y; Kyriakides, TR; Mehal, WZ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20095-20100 , 文章类型: Article,,卷期:2011年108-50]
- Implantation of biomaterials and devices into soft tissues leads to the development of the foreign body response (FBR), which can interfere with implant function and eventually lead to failure. The FBR consists of overla...
- Wnt/beta-catenin signaling is differentially regulated by G alpha proteins and contributes to fibrous dysplasia
[作者:Regard, JB; Cherman, N; Palmer, D; Kuznetsov, SA; Celi, FS; Guettier, JM; Chen, M; Bhattacharyya, N; Wess, J; Coughlin, SR; Weinstein, LS; Collins, MT; Robey, PG; Yang, YZ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20101-20106 , 文章类型: Article,,卷期:2011年108-50]
- Skeletal dysplasias are common disabling disorders characterized by aberrant growth of bone and cartilage leading to abnormal skeletal structures and functions, often attributable to defects in skeletal progenitor cells....
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