- The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor
[作者:Welinder, E; Mansson, R; Mercer, EM; Bryder, D; Sigvardsson, M; Murre, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17402-17407 , 文章类型: Article,,卷期:2011年108-42]
- Recent studies have identified a number of transcriptional regulators, including E proteins, EBF1, FOXO1, and PAX5, that act together to orchestrate the B-cell fate. However, it still remains unclear as to how they are l...
- Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b
[作者:Rajaram, MVS; Ni, B; Morris, JD; Brooks, MN; Carlson, TK; Bakthavachalu, B; Schoenberg, DR; Torrelles, JB; Schlesinger, LS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17408-17413 , 文章类型: Article,,卷期:2011年108-42]
- Contact of Mycobacterium tuberculosis (M.tb) with the immune system requires interactions between microbial surface molecules and host pattern recognition receptors. Major M.tb-exposed cell envelope molecules, such as li...
- Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer
[作者:Gillespie, E; Leeman, SE; Watts, LA; Coukos, JA; O'Brien, MJ; Cerda, SR; Farraye, FA; Stucchi, AF; Becker, JM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17420-17425 , 文章类型: Article,,卷期:2011年108-42]
- Patients with chronic ulcerative colitis (UC) are at high risk for developing colorectal cancer. In this study, archival formalin-fixed paraffin-embedded colonic tissue from patients with UC who developed carcinoma (CA) ...
- Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection
[作者:Hara, Y; Kanagawa, M; Kunz, S; Yoshida-Moriguchi, T; Satz, JS; Kobayashi, YM; Zhu, ZH; Burden, SJ; Oldstone, MBA; Campbell, KP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17426-17431 , 文章类型: Article,,卷期:2011年108-42]
- alpha-dystroglycan is a highly O-glycosylated extracellular matrix receptor that is required for anchoring of the basement membrane to the cell surface and for the entry of Old World arenaviruses into cells. Like-acetylg...
- Lymphomas that recur after MYC suppression continue to exhibit oncogene addiction
[作者:Choi, PS; van Riggelen, J; Gentles, AJ; Bachireddy, P; Rakhra, K; Adam, SJ; Plevritis, SK; Felsher, DW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17432-17437 , 文章类型: Article,,卷期:2011年108-42]
- The suppression of oncogenic levels of MYC is sufficient to induce sustained tumor regression associated with proliferative arrest, differentiation, cellular senescence, and/or apoptosis, a phenomenon known as oncogene a...
- Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex
[作者:Andrejka, L; Wen, H; Ashton, J; Grant, M; Iori, K; Wang, A; Manak, JR; Lipsick, JS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17438-17443 , 文章类型: Article,,卷期:2011年108-42]
- Members of the Myb oncoprotein and E2F-Rb tumor suppressor protein families are present within the same highly conserved multiprotein transcriptional repressor complex, named either as Myb and synthetic multivuval class ...
- Distant Mimivirus relative with a larger genome highlights the fundamental features of Megaviridae
[作者:Arslan, D; Legendre, M; Seltzer, V; Abergel, C; Claverie, JM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17486-17491 , 文章类型: Article,,卷期:2011年108-42]
- Mimivirus, a DNA virus infecting acanthamoeba, was for a long time the largest known virus both in terms of particle size and gene content. Its genome encodes 979 proteins, including the first four aminoacyl tRNA synthet...
- Caenorhabditis elegans selects distinct crawling and swimming gaits via dopamine and serotonin
[作者:Vidal-Gadea, A; Topper, S; Young, L; Crisp, A; Kressin, L; Elbel, E; Maples, T; Brauner, M; Erbguth, K; Axelrod, A; Gottschalk, A; Siegel, D; Pierce-Shimomura, JT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17504-17509 , 文章类型: Article,,卷期:2011年108-42]
- Many animals, including humans, select alternate forms of motion (gaits) to move efficiently in different environments. However, it is unclear whether primitive animals, such as nematodes, also use this strategy. We used...
- Conformational trapping of Mismatch Recognition Complex MSH2/MSH3 on repair-resistant DNA loops
[作者:Lang, WH; Coats, JE; Majka, J; Hura, GL; Lin, YY; Rasnik, I; McMurray, CT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E837-E844 , 文章类型: Article,,卷期:2011年108-42]
- Insertion and deletion of small heteroduplex loops are common mutations in DNA, but why some loops are prone to mutation and others are efficiently repaired is unknown. Here we report that the mismatch recognition comple...
- Cryo-electron tomography reveals conserved features of doublet microtubules in flagella
[作者:Nicastro, D; Fu, XF; Heuser, T; Tso, A; Porter, ME; Linck, RW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E845-E853 , 文章类型: Article,,卷期:2011年108-42]
- The axoneme forms the essential and conserved core of cilia and flagella. We have used cryo-electron tomography of Chlamydomonas and sea urchin flagella to answer long-standing questions and to provide information about ...
- PI3K gamma within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance
[作者:Becattini, B; Marone, R; Zani, F; Arsenijevic, D; Seydoux, J; Montani, JP; Dulloo, AG; Thorens, B; Preitner, F; Wymann, MP; Solinas, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E854-E863 , 文章类型: Article,,卷期:2011年108-42]
- Obesity is associated with a chronic low-grade inflammation, and specific antiinflammatory interventions may be beneficial for the treatment of type 2 diabetes and other obesity-related diseases. The lipid kinase PI3K ga...
- Frequency selectivity in Old-World monkeys corroborates sharp cochlear tuning in humans
[作者:Joris, PX; Bergevin, C; Kalluri, R; Mc Laughlin, M; Michelet, P; van der Heijden, M; Shera, CA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17516-17520 , 文章类型: Article,,卷期:2011年108-42]
- Frequency selectivity in the inner ear is fundamental to hearing and is traditionally thought to be similar across mammals. Although direct measurements are not possible in humans, estimates of frequency tuning based on ...
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