- ADAM-17/Tumor Necrosis Factor-alpha-Converting Enzyme Inhibits Neurogenesis and Promotes Gliogenesis from Neural Stem Cells
[作者:Romero-Grimaldi, C; Murillo-Carretero, M; Lopez-Toledano, MA; Carrasco, M; Castro, C; Estrada, C,期刊:Stem Cells, 页码:1628-1639 , 文章类型: Article,,卷期:2011年29-10]
- Neural precursor cells (NPCs) are activated in central nervous system injury. However, despite being multipotential, their progeny differentiates into astrocytes rather than neurons in situ. We have investigated the role...
- Brief Report: Chimeric Pigs Produced from Induced Pluripotent Stem Cells Demonstrate Germline Transmission and No Evidence of Tumor Formation in Young Pigs
[作者:West, FD; Uhl, EW; Liu, YB; Stowe, H; Lu, YQ; Yu, P; Gallegos-Cardenas, A; Pratt, SL; Stice, SL,期刊:Stem Cells, 页码:1640-1643 , 文章类型: Article,,卷期:2011年29-10]
- The recent development of porcine induced pluripotent stem cells (piPSCs) capable of generating chimeric animals, a feat not previously accomplished with embryonic stem cells or iPSCs in a species outside of rodents, has...
- CD133(+) Cancer Stem Cell-like Cells Derived from Uterine Carcinosarcoma (Malignant Mixed Mullerian Tumor)
[作者:Choijamts, B; Jimi, S; Kondo, T; Naganuma, Y; Matsumoto, T; Kuroki, M; Iwasaki, H; Emoto, M,期刊:Stem Cells, 页码:1485-1495 , 文章类型: Article,,卷期:2011年29-10]
- Cancer stem cells (CSCs) that display tumor-initiating properties have recently been identified. CD133, a surface glycoprotein linked to organ-specific stem cells, has been described as a marker of CSCs in different tumo...
- Distinct Developmental Ground States of Epiblast Stem Cell Lines Determine Different Pluripotency Features
[作者:Bernemann, C; Greber, B; Ko, K; Sterneckert, J; Han, DW; Arauzo-Bravo, MJ; Scholer, HR,期刊:Stem Cells, 页码:1496-1503 , 文章类型: Article,,卷期:2011年29-10]
- Epiblast stem cells (EpiSCs) are pluripotent stem cells derived from mouse postimplantation embryos at embryonic day (E) 5.5-E7.5 at the onset of gastrulation, which makes them a valuable tool for studying mammalian post...
- The RNA-Binding Protein Unr Prevents Mouse Embryonic Stem Cells Differentiation Toward the Primitive Endoderm Lineage
[作者:Elatmani, H; Dormoy-Raclet, V; Dubus, P; Dautry, F; Chazaud, C; Jacquemin-Sablon, H,期刊:Stem Cells, 页码:1504-1516 , 文章类型: Article,,卷期:2011年29-10]
- The maintenance of embryonic stem cells (ESCs) pluripotency depends on key transcription factors, chromatin remodeling proteins, and microRNAs. The roles of RNA-binding proteins are however poorly understood. We report t...
- A Novel Role for an RNA Polymerase III Subunit POLR3G in Regulating Pluripotency in Human Embryonic Stem Cells
[作者:Wong, RCB; Pollan, S; Fong, H; Ibrahim, A; Smith, EL; Ho, M; Laslett, AL; Donovan, PJ,期刊:Stem Cells, 页码:1517-1527 , 文章类型: Article,,卷期:2011年29-10]
- The pluripotency of human embryonic stem cells (hESC) could have great potential for the development of cell replacement therapies. Previous studies have converged on the finding that OCT4, SOX2, and NANOG serve as key r...
- Mesenchymal Stem Cells Expressing Insulin-Like Growth Factor-I (MSC(IGF)) Promote Fracture Healing and Restore New Bone Formation in Irs1 Knockout Mice: Analyses of MSC(IGF) Autocrine and Paracrine Regenerative Effects
[作者:Granero-Molto, F; Myers, TJ; Weis, JA; Longobardi, L; Li, TS; Yan, Y; Case, N; Rubin, J; Spagnoli, A,期刊:Stem Cells, 页码:1537-1548 , 文章类型: Article,,卷期:2011年29-10]
- Failures of fracture repair (nonunions) occur in 10% of all fractures. The use of mesenchymal stem cells (MSC) in tissue regeneration appears to be rationale, safe, and feasible. The contributions of MSC to the reparativ...
- Pretreatment with Interferon-gamma Enhances the Therapeutic Activity of Mesenchymal Stromal Cells in Animal Models of Colitis
[作者:Duijvestein, M; Wildenberg, ME; Welling, MM; Hennink, S; Molendijk, I; van Zuylen, VL; Bosse, T; Vos, ACW; de Jonge-Muller, ESM; Roelofs, H; van der Weerd, L; Verspaget, HW; Fibbe, WE; Velde, AAT; van den Brink, GR; Hommes, DW,期刊:Stem Cells, 页码:1549-1558 , 文章类型: Article,,卷期:2011年29-10]
- Mesenchymal stromal cells (MSCs) are currently under investigation for the treatment of inflammatory disorders, including Crohn's disease. MSCs are pluripotent cells with immunosuppressive properties. Recent data suggest...
- Neural Stem Cell Gene Therapy Ameliorates Pathology and Function in a Mouse Model of Globoid Cell Leukodystrophy
[作者:Neri, M; Ricca, A; di Girolamo, I; Alcala'-Franco, B; Cavazzin, C; Orlacchio, A; Martino, S; Naldini, L; Gritti, A,期刊:Stem Cells, 页码:1559-1571 , 文章类型: Article,,卷期:2011年29-10]
- Murine neural stem cells (mNSCs), either naive or genetically modified to express supranormal levels of beta-galactocerebrosidase (GALC), were transplanted into the brain of Twitcher mice, a murine model of globoid cell ...
- Action at a Distance: Systemically Administered Adult Stem/Progenitor Cells (MSCs) Reduce Inflammatory Damage to the Cornea Without Engraftment and Primarily by Secretion of TNF-alpha Stimulated Gene/Protein 6
[作者:Roddy, GW; Oh, JY; Lee, RH; Bartosh, TJ; Ylostalo, J; Coble, K; Rosa, RH; Prockop, DJ,期刊:Stem Cells, 页码:1572-1579 , 文章类型: Article,,卷期:2011年29-10]
- Previous reports demonstrated that the deleterious effects of chemical injury to the cornea were ameliorated by local or systemic administration of adult stem/progenitor cells from bone marrow referred to as mesenchymal ...
- Inducible Cassette Exchange: A Rapid and Efficient System Enabling Conditional Gene Expression in Embryonic Stem and Primary Cells
[作者:Iacovino, M; Bosnakovski, D; Fey, H; Rux, D; Bajwa, G; Mahen, E; Mitanoska, A; Xu, ZH; Kyba, M,期刊:Stem Cells, 页码:1580-1588 , 文章类型: Article,,卷期:2011年29-10]
- Genetic modification is critically enabling for studies addressing specification and maintenance of cell fate; however, methods for engineering modifications are inefficient. We demonstrate a rapid and efficient recombin...
- Transcriptome Analysis of Neural Progenitor Cells by a Genetic Dual Reporter Strategy
[作者:Wang, J; Zhang, HY; Young, AG; Qiu, RX; Argalian, S; Li, XJ; Wu, XW; Lemke, G; Lu, Q,期刊:Stem Cells, 页码:1589-1600 , 文章类型: Article,,卷期:2011年29-10]
- Global analysis of stem/progenitor cells promises new insight into mechanisms that govern self-renewal and cellular potential, an unresolved question of stem/progenitor cell biology. Despite rapid advance of genome-wide ...
- Tumor Necrosis Factor Inhibits Mesenchymal Stem Cell Differentiation into Osteoblasts Via the Ubiquitin E3 Ligase Wwp1
[作者:Zhao, L; Huang, J; Zhang, HW; Wang, Y; Matesic, LE; Takahata, M; Awad, H; Chen, D; Xing, LP,期刊:Stem Cells, 页码:1601-1610 , 文章类型: Article,,卷期:2011年29-10]
- Patients with chronic inflammatory disorders, such as rheumatoid arthritis, often have osteoporosis due to a combination of Tumor necrosis factor-induced increased bone resorption and reduced bone formation. To test if T...
|