- Concise Review: Induced Pluripotent Stem Cells and Lineage Reprogramming: Prospects for Bone Regeneration
[作者:Illich, DJ; Demir, N; Stojkovic, M; Scheer, M; Rothamel, D; Neugebauer, J; Hescheler, J; Zoller, JE,期刊:Stem Cells, 页码:555-563 , 文章类型: Review,,卷期:2011年29-4]
- Bone tissue for transplantation therapies is in high demand in clinics. Osteodegenerative diseases, in particular, osteoporosis and osteoarthritis, represent serious public health issues affecting a respectable proportio...
- Combination of a Ptgs2 Inhibitor and an Epidermal Growth Factor Receptor-Signaling Inhibitor Prevents Tumorigenesis of Oligodendrocyte Lineage-Derived Glioma-Initiating Cells
[作者:Hide, T; Takezaki, T; Nakatani, Y; Nakamura, H; Kuratsu, J; Kondo, T,期刊:Stem Cells, 页码:590-599 , 文章类型: Article,,卷期:2011年29-4]
- Recent findings have demonstrated that malignant tumors, including glioblastoma multiforme (GBM), contain cancer-initiating cells (CICs; also known as cancer stem cells), which self-renew and are malignant. However, it r...
- Molecular and Functional Characterizations of Gastrula Organizer Cells Derived from Human Embryonic Stem Cells
[作者:Sharon, N; Mor, I; Golan-lev, T; Fainsod, A; Benvenisty, N,期刊:Stem Cells, 页码:600-608 , 文章类型: Article,,卷期:2011年29-4]
- The Spemann-Mangold organizer is the structure that provides the signals, which initiate pattern formation in the developing vertebrate embryo, affecting the main body axes. Very little is known about axial induction in ...
- CD24: A Novel Surface Marker for PDX1-Positive Pancreatic Progenitors Derived from Human Embryonic Stem Cells
[作者:Jiang, W; Sui, X; Zhang, DH; Liu, M; Ding, MX; Shi, Y; Deng, HK,期刊:Stem Cells, 页码:609-617 , 文章类型: Article,,卷期:2011年29-4]
- Human ESCs provide a promising cell resource for the treatment of type I diabetes mellitus. Although PDX1-positive pancreatic progenitors can be efficiently generated from human ESCs by stepwise induction, further in vit...
- Self-Renewal Versus Lineage Commitment of Embryonic Stem Cells: Protein Kinase C Signaling Shifts the Balance
[作者:Dutta, D; Ray, S; Home, P; Larson, M; Wolfe, MW; Paul, S,期刊:Stem Cells, 页码:618-628 , 文章类型: Article,,卷期:2011年29-4]
- The intricate molecular mechanisms that regulate ESC pluripotency are incompletely understood. Prior research indicated that activation of the Janus kinase-signal transducer and activator of transcription (STAT3) pathway...
- Specific Glycosaminoglycans Modulate Neural Specification of Mouse Embryonic Stem Cells
[作者:Pickford, CE; Holley, RJ; Rushton, G; Stavridis, MP; Ward, CM; Merry, CLR,期刊:Stem Cells, 页码:629-640 , 文章类型: Article,,卷期:2011年29-4]
- Mouse embryonic stem (mES) cells express a low sulfated form of heparan sulfate (HS). HS chains displayed by ES cells and their progeny become more complex and more sulfated during progression from pluripotency to neuroe...
- LacdiNAc (GalNAc beta 1-4GlcNAc) Contributes to Self-Renewal of Mouse Embryonic Stem Cells by Regulating Leukemia Inhibitory Factor/STAT3 Signaling
[作者:Sasaki, N; Shinomi, M; Hirano, K; Ui-Tei, K; Nishihara, S,期刊:Stem Cells, 页码:641-650 , 文章类型: Article,,卷期:2011年29-4]
- Self-renewal of mouse embryonic stem cells (mESCs) is maintained by leukemia inhibitory factor (LIF)/signal transducer and activator of transcription (STAT3) signaling. However, this signaling control does not function i...
- An Important Role for CDK2 in G1 to S Checkpoint Activation and DNA Damage Response in Human Embryonic Stem Cells
[作者:Neganova, I; Vilella, F; Atkinson, SP; Lloret, M; Passos, JF; von Zglinicki, T; O'Connor, JE; Burks, D; Jones, R; Armstrong, L; Lako, M,期刊:Stem Cells, 页码:651-659 , 文章类型: Article,,卷期:2011年29-4]
- A precise understanding of mechanisms used by human embryonic stem cells (hESCs) to maintain genomic integrity is very important for their potential clinical applications. The G1 checkpoint serves to protect genomic inte...
- Promyelocytic Leukemia Protein in Retinoic Acid-Induced Chromatin Remodeling of Oct4 Gene Promoter
[作者:Chuang, YS; Huang, WH; Park, SW; Persaud, SD; Hung, CH; Ho, PC; Wei, LN,期刊:Stem Cells, 页码:660-669 , 文章类型: Article,,卷期:2011年29-4]
- Promyelocytic leukemia (Pml) protein is required for Oct4 gene expression and the maintenance of its open chromatin conformation in stem cells. In proliferating stem cells, Pml-nuclear body, along with transcription fact...
- Functional Effects of Adult Human Olfactory Stem Cells on Early-Onset Sensorineural Hearing Loss
[作者:Pandit, SR; Sullivan, JM; Egger, V; Borecki, AA; Oleskevich, S,期刊:Stem Cells, 页码:670-677 , 文章类型: Article,,卷期:2011年29-4]
- Transplantation of exogenous stem cells has been proposed as a treatment to prevent or reverse sensorineural hearing loss. Here, we investigate the effects of transplantation of adult human olfactory mucosa-derived stem ...
- Transforming Growth Factor beta-Mediated Sox10 Suppression Controls Mesenchymal Progenitor Generation in Neural Crest Stem Cells
[作者:John, N; Cinelli, P; Wegner, M; Sommer, L,期刊:Stem Cells, 页码:689-699 , 文章类型: Article,,卷期:2011年29-4]
- During vertebrate development, neural crest stem cells (NCSCs) give rise to neural cells of the peripheral nervous system and to a variety of mesenchymal cell types, including smooth muscle, craniofacial chondrocytes, an...
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