- Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of Hemochromatosis
[作者：Corradini, E; Garuti, C; Montosi, G; Ventura, P; Andriopoulos, B; Lin, HY; Pietrangelo, A; Babitt, JL,期刊：Gastroenterology, 页码：1489-1497 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND AND AIMS: Mutations in HFE are the most common cause of the iron-overload disorder hereditary hemochromatosis. Levels of the main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemoch...
- Liver Sinusoidal Endothelial Cell Lectin, LSECtin, Negatively Regulates Hepatic T-Cell Immune Response
[作者：Tang, L; Yang, JT; Liu, WL; Tang, XM; Chen, J; Zhao, DY; Wang, M; Xu, F; Lu, YT; Liu, B; Sun, QH; Zhang, LQ; He, FC,期刊：Gastroenterology, 页码：1498-1508 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: The liver is an organ with paradoxic immunologic properties and is known for its tolerant microenvironment, which holds important implications for hepatic diseases. The molecular basis for this local i...
- Deletion of TRPC3 in Mice Reduces Store-Operated Ca2+ Influx and the Severity of Acute Pancreatitis
[作者：Kim, MS; Hong, JH; Li, Q; Shin, DM; Abramowitz, J; Birnbaumer, L; Muallem, S,期刊：Gastroenterology, 页码：1509-1517 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Receptor-stimulated Ca2+ influx is a critical component of the Ca2+ signal and mediates all cellular functions regulated by Ca2+. However, excessive Ca2+ influx is highly toxic, resulting in cell death...
- Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo
[作者：Tsvilovskyy, VV; Zholos, AV; Aberle, T; Philipp, SE; Dietrich, A; Zhu, MX; Birnbaumer, L; Freichel, M; Flockerzi, V,期刊：Gastroenterology, 页码：1415-1424 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Downstream effects of muscarinic receptor stimulation in intestinal smooth muscle include contraction and intestinal transit. We thought to determine whether classic transient receptor potential (TRPC)...
- Oral Cholic Acid for Hereditary Defects of Primary Bile Acid Synthesis: A Safe and Effective Long-term Therapy
[作者：Gonzales, E; Gerhardt, MF; Fabre, M; Setchell, KDR; Davit-Spraul, A; Vincent, I; Heubi, JE; Bernard, O; Jacquemin, E,期刊：Gastroenterology, 页码：1310-1320 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Oral bile acid replacement has been shown to be an effective therapy in primary bile acid synthesis defects, but to date there have been no reports of the long-term effects of this therapy. The aim of ...
- The Ets-Domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium
[作者：Gregorieff, A; Stange, DE; Kujala, P; Begthel, H; Van den Born, M; Korving, J; Peters, PJ; Clevers, H,期刊：Gastroenterology, 页码：1333-1345 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Stem cells within the intestinal epithelium generate daughter cells that undergo lineage commitment and maturation through the combined action of the Writ and Notch signaling cascades. Both pathways, i...
- Pathogenic Bacteria Induce Colonic PepT1 Expression: An Implication in Host Defense Response
[作者：Hang, TTN; Dalmasso, G; Powell, KR; Yan, YT; Bhatt, S; Kalman, D; Sitaraman, SV; Merlin, D,期刊：Gastroenterology, 页码：1435-1447 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Expression of the di/tripeptide transporter PepT1 has been observed in the colon under inflammatory conditions; however, the inducing Factors and underlying mechanisms remain unknown. Here, we address ...
- FOXP3 Expression in Hepatitis C Virus-Specific CD4(+) T Cells During Acute Hepatitis C
[作者：Heeg, MHJ; Ulsenheimer, A; Gruner, NH; Zachoval, R; Jung, MC; Gerlach, JT; Raziorrouh, B; Schraut, W; Horster, S; Kauke, T; Spannagl, M; Diepolder, HM,期刊：Gastroenterology, 页码：1280-1288 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: Down-regulation of hepatitis C virus (HCV)-specific CD4(+) T-cell responses is a hallmark of chronic viral persistence in acute hepatitis C. FOXP3(+)CD25(+)CD4(+) regulatory T cells can modulate HCV-sp...
- c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice
[作者：Kodama, Y; Kisseleva, T; Iwaisako, K; Miura, K; Taura, K; De Minicis, S; Osterreicher, CH; Schnabl, B; Seki, E; Brenner, DA,期刊：Gastroenterology, 页码：1467-1477 , 文章类型： Article，,卷期：2009年137-4]
- BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK) plays a pivotal role in the development of the metabolic syndrome including nonalcoholic fatty liver disease. However, the mechanism underlying the contribution of JNK to ...
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