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  • A polymorphism in CALHM1 influences Ca2+ homeostasis, A beta levels, and Alzheimer's disease risk
    [作者:Dreses-Werringloer, U; Lambert, JC; Vingtdeux, V; Zhao, HT; Vais, H; Siebert, A; Jain, A; Koppel, J; Rovelet-Lecrux, A; Hannequin, D; Pasquier, F; Galimberti, D; Scarpini, E; Mann, D; Lendon, C; Campion, D; Amouyel, P; Davies, P; Foskett, JK; Campagne, F; Marambaud, P,期刊:Cell, 页码:1149-1161 , 文章类型: Article,,卷期:2008年133-7]
  • Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (A beta) peptide deposition. Using TissueInfo to screen for genes preferentially expre...
  • Nanoscale organization of Hedgehog is essential for long-range signaling
    [作者:Vyas, N; Goswami, D; Manonmani, A; Sharma, P; Ranganath, HA; VijayRaghavan, K; Shashidhara, LS; Sowdhamini, R; Mayor, S,期刊:Cell, 页码:1214-1227 , 文章类型: Article,,卷期:2008年133-7]
  • Hedgehog (Hh) plays crucial roles in tissue-patterning and activates signaling in Patched (Ptc)-expressing cells. Paracrine signaling requires release and transport over many cell diameters away by a process that require...
  • Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences
    [作者:Berger, MF; Badis, G; Gehrke, AR; Talukder, S; Philippakis, AA; Pena-Castillo, L; Alleyne, TM; Mnaimneh, S; Botvinnik, OB; Chan, ET; Khalid, F; Zhang, W; Newburger, D; Jaeger, SA; Morris, QD; Bulyk, ML; Hughes, TR,期刊:Cell, 页码:1266-1276 , 文章类型: Article,,卷期:2008年133-7]
  • Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise DNA-binding specificities. We determined the binding preferences ...
  • Team effort by TRAPP forces a nucleotide fumble
    [作者:Nottingham, RM; Pfeffer, SR,期刊:Cell, 页码:1141-1143 , 文章类型: News Item,,卷期:2008年133-7]
  • TRAPPI is a multisubunit protein complex on the Golgi that activates the small GTPase Ypt1p to facilitate the receipt of transport vesicles inbound from the endoplasmic reticulum. Cai et al. (2008) now present structural...