- A polymorphism in CALHM1 influences Ca2+ homeostasis, A beta levels, and Alzheimer's disease risk
[作者:Dreses-Werringloer, U; Lambert, JC; Vingtdeux, V; Zhao, HT; Vais, H; Siebert, A; Jain, A; Koppel, J; Rovelet-Lecrux, A; Hannequin, D; Pasquier, F; Galimberti, D; Scarpini, E; Mann, D; Lendon, C; Campion, D; Amouyel, P; Davies, P; Foskett, JK; Campagne, F; Marambaud, P,期刊:Cell, 页码:1149-1161 , 文章类型: Article,,卷期:2008年133-7]
- Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (A beta) peptide deposition. Using TissueInfo to screen for genes preferentially expre...
- Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells
[作者:Dejosez, M; Krumenacker, JS; Zitur, LJ; Passeri, M; Chu, LF; Zhou, SY; Thomson, JA; Zwaka, TP,期刊:Cell, 页码:1162-1174 , 文章类型: Article,,卷期:2008年133-7]
- Pluripotency is a unique biological state that allows cells to differentiate into any tissue type. Here we describe a candidate pluripotency factor, Ronin, that possesses a THAP domain, which is associated with sequence-...
- An extended transcriptional network for pluripotency of embryonic stem cells (vol 132, pg 1049, 2008)
[作者:Kim, J; Chu, JL; Shen, XH; Wang, JL; Orkin, SH,期刊:Cell, 页码:1290-1290 , 文章类型: Correction,,卷期:2008年133-7]
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- Acetylation is indispensable for p53 activation (vol 133, pg 612, 2008)
[作者:Tang, Y; Zhao, WH; Chen, Y; Zhao, YM; Gu, W,期刊:Cell, 页码:1290-1290 , 文章类型: Correction,,卷期:2008年133-7]
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- Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope
[作者:Koszul, R; Kim, KP; Prentiss, M; Kleckner, N; Kameoka, S,期刊:Cell, 页码:1188-1201 , 文章类型: Article,,卷期:2008年133-7]
- Chromosome movement is prominent during meiosis. Here, using a combination of in vitro and in vivo approaches, we elucidate the basis for dynamic mid-prophase telomere-led chromosome motion in budding yeast. Diverse find...
- Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination
[作者:Conrad, MN; Lee, CY; Chao, G; Shinohara, M; Kosaka, H; Shinohara, A; Conchello, JA; Dresser, ME,期刊:Cell, 页码:1175-1187 , 文章类型: Article,,卷期:2008年133-7]
- Haploidization of the genome in meiosis requires that chromosomes be sorted exclusively into pairs stabilized by synaptonemal complexes (SCs) and crossovers. This sorting and pairing is accompanied by active chromosome p...
- The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes
[作者:Cai, YY; Chin, HF; Lazarova, D; Menon, S; Fu, CM; Cai, HQ; Sclafani, A; Rodgers, DW; De La Cruz, EM; Ferro-Novick, S; Reinisch, KM,期刊:Cell, 页码:1202-1213 , 文章类型: Article,,卷期:2008年133-7]
- The multimeric membrane-tethering complexes TRAPPI and TRAPPII share seven subunits, of which four (Bet3p, Bet5p, Trs23p, and Trs31p) are minimally needed to activate the Rab GTPase Ypt1p in an event preceding membrane f...
- Nanoscale organization of Hedgehog is essential for long-range signaling
[作者:Vyas, N; Goswami, D; Manonmani, A; Sharma, P; Ranganath, HA; VijayRaghavan, K; Shashidhara, LS; Sowdhamini, R; Mayor, S,期刊:Cell, 页码:1214-1227 , 文章类型: Article,,卷期:2008年133-7]
- Hedgehog (Hh) plays crucial roles in tissue-patterning and activates signaling in Patched (Ptc)-expressing cells. Paracrine signaling requires release and transport over many cell diameters away by a process that require...
- DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1
[作者:Ly, A; Nikolaev, A; Suresh, G; Zheng, YF; Tessier-Lavigne, M; Stein, E,期刊:Cell, 页码:1241-1254 , 文章类型: Article,,卷期:2008年133-7]
- During nervous system development, spinal commissural axons project toward and across the ventral midline. They are guided in part by netrin-1, made by midline cells, which attracts the axons by activating the netrin rec...
- Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences
[作者:Berger, MF; Badis, G; Gehrke, AR; Talukder, S; Philippakis, AA; Pena-Castillo, L; Alleyne, TM; Mnaimneh, S; Botvinnik, OB; Chan, ET; Khalid, F; Zhang, W; Newburger, D; Jaeger, SA; Morris, QD; Bulyk, ML; Hughes, TR,期刊:Cell, 页码:1266-1276 , 文章类型: Article,,卷期:2008年133-7]
- Most homeodomains are unique within a genome, yet many are highly conserved across vast evolutionary distances, implying strong selection on their precise DNA-binding specificities. We determined the binding preferences ...
- Activation of pheromone-sensitive neurons is mediated by conformational activation of pheromone-binding protein
[作者:Laughlin, JD; Ha, TS; Jones, DNM; Smith, DP,期刊:Cell, 页码:1255-1265 , 文章类型: Article,,卷期:2008年133-7]
- Detection of volatile odorants by olfactory neurons is thought to result from direct activation of seven-transmembrane odorant receptors by odor molecules. Here, we show that detection of the Drosophila pheromone, 11-cis...
- Analysis of homeodomain specificities allows the family-wide prediction of preferred recognition sites
[作者:Noyes, MB; Christensen, RG; Wakabayashi, A; Stormo, GD; Brodsky, MH; Wolfe, SA,期刊:Cell, 页码:1277-1289 , 文章类型: Article,,卷期:2008年133-7]
- We describe the comprehensive characterization of homeodomain DNA-binding specificities from a metazoan genome. The analysis of all 84 independent homeodomains from D. melanogaster reveals the breadth of DNA sequences th...
- Team effort by TRAPP forces a nucleotide fumble
[作者:Nottingham, RM; Pfeffer, SR,期刊:Cell, 页码:1141-1143 , 文章类型: News Item,,卷期:2008年133-7]
- TRAPPI is a multisubunit protein complex on the Golgi that activates the small GTPase Ypt1p to facilitate the receipt of transport vesicles inbound from the endoplasmic reticulum. Cai et al. (2008) now present structural...
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