个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共27条记录   A complete neandertal mitochondrial genome sequence determined by high-throughput Sequencing [作者：Green, RE; Malaspinas, AS; Krause, J; Briggs, AW; Johnson, PLF; Uhler, C; Meyer, M; Good, JM; Maricic, T; Stenzel, U; Prufer, K; Siebauer, M; Burbano, HA; Ronan, M; Rothberg, JM; Egholm, M; Rudan, P; Brajkovic, D; Kucan, Z; Gusic, I; Wikstrom, M; Laakkonen, L; Kelso, J; Slatkin, M; Paabo, S,期刊：Cell, 页码：416-426 , 文章类型： Article，,卷期：2008年134-3] A complete mitochondrial (mt) genome sequence was reconstructed from a 38,000 year-old Neandertal individual with 8341 mtDNA sequences identified among 4.8 Gb of DNA generated from similar to 0.3 g of bone. Analysis of t... AMPK and PPAR delta Agonists are exercise mimetics [作者：Narkar, VA; Downes, M; Yu, RT; Embler, E; Wang, YX; Banayo, E; Mihaylova, MM; Nelson, MC; Zou, YH; Juguilon, H; Kang, H; Shaw, RJ; Evans, RM,期刊：Cell, 页码：405-415 , 文章类型： Article，,卷期：2008年134-3] The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. Although certain natural compoun... Fluorescence mapping of mitochondrial TM23 complex reveals a water-facing, substrate-interacting helix surface [作者：Alder, NN; Jensen, RE; Johnson, AE,期刊：Cell, 页码：439-450 , 文章类型： Article，,卷期：2008年134-3] Protein translocation across the mitochondrial inner membrane is mediated by the TIM23 complex. While its central component, Tim23, is believed to form a protein-conducting channel, the regions of this subunit that face ... A network of nuclear envelope membrane proteins linking centromeres to microtubules [作者：King, MC; Drivas, TG; Blobel, G,期刊：Cell, 页码：427-438 , 文章类型： Article，,卷期：2008年134-3] In the fission yeast S. pombe, nuclei are actively positioned at the cell center by microtubules. Here, we show that cytoplasmic microtubules are mechanically coupled to the nuclear heterochromatin through proteins embed... p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling [作者：Budanov, AV; Karin, M,期刊：Cell, 页码：451-460 , 文章类型： Article，,卷期：2008年134-3] The tumor suppressor p53 is activated upon genotoxic and oxidative stress and in turn inhibits cell proliferation and growth through induction of specific target genes. Cell growth is positively regulated by mTOR, whose ... Structural basis for cargo regulation of COPII coat assembly [作者：Stagg, SM; LaPointe, P; Razvi, A; Gurkan, C; Potter, CS; Carragher, B; Balch, WE,期刊：Cell, 页码：474-484 , 文章类型： Article，,卷期：2008年134-3] Using cryo-electron microscopy, we have solved the structure of an icosidodecahedral COPII coat involved in cargo export from the endoplasmic reticulum ( ER) coassembled from purified cargo adaptor Sec23-24 and Sec13-31 ... Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi [作者：Swem, LR; Swem, DL; Wingreen, NS; Bassler, BL,期刊：Cell, 页码：461-473 , 文章类型： Article，,卷期：2008年134-3] Quorum sensing, a process of bacterial cell-cell communication, relies on production, detection, and response to autoinducer signaling molecules. LuxN, a nine-transmembrane domain protein from Vibrio harveyi, is the foun... The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation [作者：Hansen, G; Hercus, TR; McClure, BJ; Stomski, FC; Dottore, M; Powell, J; Ramshaw, H; Woodcock, JM; Xu, YB; Guthridge, M; McKinstry, WJ; Lopez, AF; Parker, MW,期刊：Cell, 页码：496-507 , 文章类型： Article，,卷期：2008年134-3] Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic cytokine that controls the production and function of blood cells, is deregulated in clinical conditions such as rheumatoid arthritis and leukemi... Phosphorylation of SNAP-23 by I kappa B kinase 2 regulates mast cell degranulation [作者：Suzuki, K; Verma, IM,期刊：Cell, 页码：485-495 , 文章类型： Article，,卷期：2008年134-3] Mast cells are known to play a pivotal role in allergic diseases. Cross-linking of the high-affinity receptor for IgE (Fc epsilon RI) leads to degranulation and allergic inflammation; however, the regulatory mechanisms o... Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity [作者：Sugiyama, S; Di Nardo, AA; Aizawa, S; Matsuo, I; Volovitch, M; Prochiantz, A; Hensch, TK,期刊：Cell, 页码：508-520 , 文章类型： Article，,卷期：2008年134-3] Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic connections within visual cortex determine the timing of the critical period for rewiring ocular dominance to establish visual acuity. ... A protein domain-based interactome network for C-elegans early embryogenesis [作者：Boxem, M; Maliga, Z; Klitgord, N; Li, N; Lemmens, I; Mana, M; de Lichtervelde, L; Mul, JD; van de Peut, D; Devos, M; Simonis, N; Yildirim, MA; Cokol, M; Kao, HL; de Smet, AS; Wang, HD; Schlaitz, AL; Hao, T; Milstein, S; Fan, CY; Tipsword, M; Drew, K; Galli, M; Rhrissorrakrai, K; Drechsel, D; Koller, D; Roth, FP; Iakoucheva, LM; Dunker, AK; Bonneau, R; Gunsalus, KC; Hill, DE; Piano, F; Tavernier, J; van den Heuvel, S; Hyman, AA; Vidal, M,期刊：Cell, 页码：534-545 , 文章类型： Article，,卷期：2008年134-3] Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome'' networks have largely ignored this modular organi... Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells [作者：Marson, A; Levine, SS; Cole, MF; Frampton, GM; Brambrink, T; Johnstone, S; Guenther, MG; Johnston, WK; Wernig, M; Newman, J; Calabrese, JM; Dennis, LM; Volkert, TL; Gupta, S; Love, J; Hannett, N; Sharp, PA; Bartel, DP; Jaenisch, R; Young, RA,期刊：Cell, 页码：521-533 , 文章类型： Article，,卷期：2008年134-3] MicroRNAs (miRNAs) are crucial for normal embryonic stem (ES) cell self-renewal and cellular differentiation, but how miRNA gene expression is controlled by the key transcriptional regulators of ES cells has not been est... FOXP3 is an x-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene (vol 129, pg 1275, 2007) [作者：Zuo, T; Wang, LZ; Morrison, C; Chang, X; Zhang, HM; Liu, Y; Wang, Y; Liu, XL; Chan, MWY; Liu, JQ; Love, R; Godfrey, V; Shen, RL; Huang, THM; Yang, TY; Zheng, P; Liu, Y,期刊：Cell, 页码：546-546 , 文章类型： Correction，,卷期：2008年134-3] Science in China: 30 years on [作者：Hao, X,期刊：Cell, 页码：375-377 , 文章类型： Editorial Material，,卷期：2008年134-3] A brief history of the hypothesis [作者：Glass, DJ; Hall, N,期刊：Cell, 页码：378-381 , 文章类型： Editorial Material，,卷期：2008年134-3] Gazing at translocation in the mitochondrion [作者：Walsh, S; Koehler, CM,期刊：Cell, 页码：382-383 , 文章类型： Editorial Material，,卷期：2008年134-3]