- Global Sequencing of proteolytic cleavage sites in apoptosis by specific Labeling of protein N termini
[作者：Mahrus, S; Trinidad, JC; Barkan, DT; Sali, A; Burlingame, AL; Wells, JA,期刊：Cell, 页码：866-876 , 文章类型： Article，,卷期：2008年134-5]
- The nearly 600 proteases in the human genome regulate a diversity of biological processes, including programmed cell death. Comprehensive characterization of protease signaling in complex biological samples is limited by...
- Cancer cell metabolism: Warburg and beyond
[作者：Hsu, PP; Sabatini, DM,期刊：Cell, 页码：703-707 , 文章类型： Editorial Material，,卷期：2008年134-5]
- Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for u...
- Disease-specific induced pluripotent stem cells
[作者：Park, IH; Arora, N; Huo, H; Maherali, N; Ahfeldt, T; Shimamura, A; Lensch, MW; Cowan, C; Hochedlinger, K; Daley, GQ,期刊：Cell, 页码：877-886 , 文章类型： Article，,卷期：2008年134-5]
- Tissue culture of immortal cell strains from diseased patients is an invaluable resource for medical research but is largely limited to tumor cell lines or transformed derivatives of native tissues. Here we describe the ...
- Metabolic phenotyping in health and disease
[作者：Holmes, E; Wilson, ID; Nicholson, JK,期刊：Cell, 页码：714-717 , 文章类型： Editorial Material，,卷期：2008年134-5]
- Analyzing metabolites (small molecules <1 kDa) in body fluids such as urine and plasma using various spectroscopic methods provides information on the metabotype (metabolic phenotype) of individuals or populations, infor...
- A protein scaffold plays matchmaker for chordin
[作者：Harland, RM,期刊：Cell, 页码：718-719 , 文章类型： Editorial Material，,卷期：2008年134-5]
- In this issue, Inomata et al. (2008) report that the scaffold protein Olfactomedin 1 (ONT1) recruits the Tolloid proteases to their substrate Chordin, an antagonist of bone morphogenetic proteins (BMPs), during developme...
- Highways for mRNA transport
[作者：Singer, RH,期刊：Cell, 页码：722-723 , 文章类型： Editorial Material，,卷期：2008年134-5]
- Two new studies reveal the role of microtubule polarity in the asymmetric localization of mRNAs. In this issue of Cell, Zimyanin et al. (2008) show that the asymmetric localization of oskar mRNA in fruit fly oocytes resu...
- Unresolved ER stress inflames the intestine
[作者：Ma, A,期刊：Cell, 页码：724-725 , 文章类型： Editorial Material，,卷期：2008年134-5]
- Intestinal epithelial cells interact with both microbes in the gut lumen and host immune cells. In this issue, Kaser et al. (2008) link a key mediator of endoplasmic reticulum stress, the protein XBP1, with survival of i...
- Caspase cleavage is not for everyone
[作者：Johnson, CE; Kornbluth, S,期刊：Cell, 页码：720-721 , 文章类型： Editorial Material，,卷期：2008年134-5]
- During apoptosis, caspases cleave cellular substrates to break down and package the apoptotic cell for removal. Reporting in Cell, Mahrus et al. (2008) and Dix et al. (2008) use new approaches that identify hundreds of p...
- Brown fat and skeletal muscle: Unlikely cousins?
[作者：Farmer, SR,期刊：Cell, 页码：726-727 , 文章类型： Editorial Material，,卷期：2008年134-5]
- Although the functions of white fat and brown fat are increasingly well understood, their developmental origins remain unclear. A recent study published in Nature (Seale et al., 2008) identifies a population of progenito...
- The meter of metabolism
[作者：Green, CB; Takahashi, JS; Bass, J,期刊：Cell, 页码：728-742 , 文章类型： Review，,卷期：2008年134-5]
- The circadian system orchestrates the temporal organization of many aspects of physiology, including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic system, the circadian system is a com...
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