- Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
[作者：Cao, HM; Gerhold, K; Mayers, JR; Wiest, MM; Watkins, SM; Hotamisligil, GS,期刊：Cell, 页码：933-944 , 文章类型： Article，,卷期：2008年134-6]
- Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic analyses and mice deficient in adipose tissue lipid chaperon...
- A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole
[作者：Bowman, GR; Comolli, LR; Zhu, J; Eckart, M; Koenig, M; Downing, KH; Moerner, WE; Earnest, T; Shapiro, L,期刊：Cell, 页码：945-955 , 文章类型： Article，,卷期：2008年134-6]
- Bacterial replication origins move towards opposite ends of the cell during DNA segregation. We have identified a proline-rich polar protein, PopZ, required to anchor the separated Caulobacter crescentus chromosome origi...
- Mechanism of replication-coupled DNA interstrand crosslink repair
[作者：Raschle, M; Knipsheer, P; Enoiu, M; Angelov, T; Sun, JC; Griffith, JD; Ellenberger, TE; Scharer, OD; Walter, JC,期刊：Cell, 页码：969-980 , 文章类型： Article，,卷期：2008年134-6]
- DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repai...
- A self-associating protein critical for chromosome attachment, division, and polar organization in Caulobacter
[作者：Ebersbach, G; Briegel, A; Jensen, GJ; Jacobs-Wagner, C,期刊：Cell, 页码：956-968 , 文章类型： Article，,卷期：2008年134-6]
- Cell polarization is an integral part of many unrelated bacterial processes. How intrinsic cell polarization is achieved is poorly understood. Here, we provide evidence that Caulobacter crescentus uses a multimeric pole-...
- A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms
[作者：Sawaya, MR; Wojtowicz, WM; Andre, I; Qian, B; Wu, W; Baker, D; Eisenberg, D; Zipursky, SL,期刊：Cell, 页码：1007-1018 , 文章类型： Article，,卷期：2008年134-6]
- Drosophila Dscam encodes a vast family of immunoglobulin (Ig)-containing proteins that exhibit isoform-specific homophilic binding. This diversity is essential for cell recognition events required for wiring the brain. E...
- Structural insights into NEDD8 activation of Cullin-RING ligases: Conformational control of conjugation
[作者：Duda, DM; Borg, LA; Scott, DC; Hunt, HW; Hammel, M; Schulman, BA,期刊：Cell, 页码：995-1006 , 文章类型： Article，,卷期：2008年134-6]
- Cullin-RING ligases (CRLs) comprise the largest ubiquitin E3 subclass, in which a central cullin subunit links a substrate-binding adaptor with an E2-binding RING. Covalent attachment of the ubiquitin-like protein NEDD8 ...
- Intramolecular strain coordinates kinesin stepping behavior along microtubules
[作者：Yildiz, A; Tomishige, M; Gennerich, A; Vale, RD,期刊：Cell, 页码：1030-1041 , 文章类型： Article，,卷期：2008年134-6]
- Kinesin advances 8 nm along a microtubule per ATP hydrolyzed, but the mechanism responsible for coordinating the enzymatic cycles of kinesin's two identical motor domains remains unresolved. Here, we have tested whether ...
- Expression cloning of TMEM16A as a calcium-activated chloride channel subunit
[作者：Schroeder, BC; Cheng, T; Jan, YN; Jan, LY,期刊：Cell, 页码：1019-1029 , 文章类型： Article，,卷期：2008年134-6]
- Calcium-activated chloride channels (CaCCs) are major regulators of sensory transduction, epithelial secretion, and smooth muscle contraction. Other crucial roles of CaCCs include action potential generation in Characean...
- The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP
[作者：Napoli, I; Mercaldo, V; Boyl, PP; Eleuteri, B; Zalfa, F; De Rubeis, S; Di Marino, D; Mohr, E; Massimi, M; Falconi, M; Witke, W; Costa-Mattioli, M; Sonenberg, N; Achsel, T; Bagni, C,期刊：Cell, 页码：1042-1054 , 文章类型： Article，,卷期：2008年134-6]
- Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies synaptic plasticity and brain development. The fragile X mental retardation protein (FMRP) is involved in this process; here, we s...
- Probing nucleosome function: A highly versatile library of synthetic histone H3 and H4 mutants
[作者：Dai, J; Hyland, EM; Yuan, DS; Huang, HL; Bader, JS; Boeke, JD,期刊：Cell, 页码：1066-1078 , 文章类型： Article，,卷期：2008年134-6]
- Nucleosome structural integrity underlies the regulation of DNA metabolism and transcription. Using a synthetic approach, a versatile library of 486 systematic histone H3 and H4 substitution and deletion mutants that pro...
- Kinesin motors: No strain, no gain
[作者：Cochran, JC; Kull, FJ,期刊：Cell, 页码：918-919 , 文章类型： Editorial Material，,卷期：2008年134-6]
- The processive movement of the dimeric motor protein kinesin 1 along microtubules requires communication between the two motor domains. Yildiz et al. (2008) now show that tension between the motor domains not only is nec...
- Putting a Notch in our understanding of nuclear migration
[作者：Buchman, JJ; Tsai, LH,期刊：Cell, 页码：912-914 , 文章类型： Editorial Material，,卷期：2008年134-6]
- The nuclei of progenitor cells in developing neural epithelia change their position during the cell cycle through a process called interkinetic nuclear migration. Del Bene et al. (2008) report that defects in the machine...
- Fat talks, liver and muscle listen
[作者：Olefsky, JM,期刊：Cell, 页码：914-916 , 文章类型： Editorial Material，,卷期：2008年134-6]
- Fat metabolism and glucose homeostasis are processes that are highly interconnected. Cao et al. (2008) now take this concept a step further by identifying a fatty acid metabolite generated in adipose tissue that regulate...
- Grasping at origins
[作者：Ramamurthi, KS; Losick, R,期刊：Cell, 页码：916-918 , 文章类型： Editorial Material，,卷期：2008年134-6]
- Chromosome segregation in the bacterium Caulobacter crescentus involves propulsion of the replication origin and its capture at one pole of the cell. Bowman et al. (2008) and Ebersbach et al. (2008) now report the discov...
|