- Finding the Right Partner: Science or ART?
[作者：Polo, S; Di Fiore, PP,期刊：Cell, 页码：590-592 , 文章类型： Editorial Material，,卷期：2008年135-4]
- In response to environmental cues, certain plasma membrane proteins are ubiquitinated, signaling their endocytosis and degradation. In the budding yeast, a single enzyme, Rsp5, is charged with this task. Lin et al. (2008...
- Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types
[作者：Doyle, JP; Dougherty, JD; Heiman, M; Schmidt, EF; Stevens, TR; Ma, G; Bupp, S; Shrestha, P; Shah, RD; Doughty, ML; Gong, S; Greengard, P; Heintz, N,期刊：Cell, 页码：749-762 , 文章类型： Article，,卷期：2008年135-4]
- Comparative analysis can provide important insights into complex biological systems. As demonstrated in the accompanying paper, translating ribosome affinity purification (TRAP) permits comprehensive studies of translate...
- Pol V Transcribes to Silence
[作者：Daxinger, L; Kanno, T; Matzke, M,期刊：Cell, 页码：592-594 , 文章类型： Editorial Material，,卷期：2008年135-4]
- In most cases, the functions of long noncoding RNAs remain uncertain. Working in the model plant Arabidopsis, Wierzbicki et al. (2008) provide evidence that transcription of intergenic noncoding regions by RNA polymerase...
- The Safety on the TCR Trigger
[作者：Kuhns, MS; Davis, MM,期刊：Cell, 页码：594-596 , 文章类型： Editorial Material，,卷期：2008年135-4]
- In this issue, Xu et al. (2008) provide evidence for a new mechanism of T cell receptor regulation. Prior to activation, basic residues in the cytoplasmic domain of the signaling subunits of the T cell receptor associate...
- Unlocking CNS Cell Type Heterogeneity
[作者：Emery, B; Barres, BA,期刊：Cell, 页码：596-598 , 文章类型： Editorial Material，,卷期：2008年135-4]
- A major challenge to understanding how cells work together in the central nervous system (CNS) is the heterogeneous cellular composition of the brain. In this issue, Heiman et al. (2008) and Doyle et al. (2008) introduce...
- Crosstalk among Histone Modifications
[作者：Suganuma, T; Workman, JL,期刊：Cell, 页码：604-607 , 文章类型： Editorial Material，,卷期：2008年135-4]
- Histone modifications play a complex role in the regulation of transcription. Recent studies (Duncan et al., 2008; Lee et al., 2007; Li et al., 2008) reveal that regulation of histone modifications can be functionally li...
- A Social Life for Discerning Microbes
[作者：Brown, SP; Buckling, A,期刊：Cell, 页码：600-603 , 文章类型： Editorial Material，,卷期：2008年135-4]
- Microbes are not only extremely social but also extremely discerning about whom they socialize with. Recent research has uncovered some of the evolutionary explanations behind these feats of social sophistication in bact...
- Tough Challenges for the Next NIH Director
[作者：Bonetta, L,期刊：Cell, 页码：583-585 , 文章类型： News Item，,卷期：2008年135-4]
- The new US President will be selecting the next director of the National Institutes of Health (NIH) at a time when the agency faces many challenges. Priorities for the new director include boosting the NIH coffers in tro...
- Dbf4-Dependent Cdc7 Kinase Links DNA Replication to the Segregation of Homologous Chromosomes in Meiosis I
[作者：Matos, J; Lipp, JJ; Bogdanova, A; Guillot, S; Okaz, E; Junqueira, M; Shevchenko, A; Zachariae, WG,期刊：Cell, 页码：662-678 , 文章类型： Article，,卷期：2008年135-4]
- Meiosis differs from mitosis in that DNA replication is followed by the segregation of homologous chromosomes but not sister chromatids. This depends on the formation of interhomolog connections through crossover recombi...
- H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment
[作者：Creyghton, MP; Markoulaki, S; Levine, SS; Hanna, J; Lodato, MA; Sha, K; Young, RA; Jaenisch, R; Boyer, LA,期刊：Cell, 页码：649-661 , 文章类型： Article，,卷期：2008年135-4]
- Elucidating how chromatin influences gene expression patterns and ultimately cell fate is fundamental to understanding development and disease. The histone variant H2AZ has emerged as a key regulator of chromatin functio...
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