- Structural Basis of UV DNA-Damage Recognition by the DDB1-DDB2 Complex
[作者：Scrima, A; Konickova, R; Czyzewski, BK; Kawasaki, Y; Jeffrey, PD; Groisman, R; Nakatani, Y; Iwai, S; Pavletich, NP; Thoma, NH,期刊：Cell, 页码：1213-1223 , 文章类型： Article，,卷期：2008年135-7]
- Ultraviolet (UV) light-induced pyrimidine photodimers are repaired by the nucleotide excision repair pathway. Photolesions have biophysical parameters closely resembling undamaged DNA, impeding discovery through damage s...
- DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45
[作者：Rai, K; Huggins, IJ; James, SR; Karpf, AR; Jones, DA; Cairns, BR,期刊：Cell, 页码：1201-1212 , 文章类型： Article，,卷期：2008年135-7]
- Evidence for active DNA demethylation in vertebrates is accumulating, but the mechanisms and enzymes remain unclear. Using zebrafish embryos we provide evidence for 5-methylcytosine (5-meC) removal in vivo via the coupli...
- Translation Initiation on Mammalian mRNAs with Structured 5 ' UTRs Requires DExH-Box Protein DHX29
[作者：Pisareva, VP; Pisarev, AV; Komar, AA; Hellen, CUT; Pestova, TV,期刊：Cell, 页码：1237-1250 , 文章类型： Article，,卷期：2008年135-7]
- Eukaryotic protein synthesis begins with assembly of 48S initiation complexes at the initiation codon of mRNA, which requires at least seven initiation factors (eIFs). First, 43S preinitiation complexes comprising 40S ri...
- Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5 ' Splice Site Competition
[作者：Yu, Y; Maroney, PA; Denker, JA; Zhang, XHF; Dybkov, O; Luhrmann, R; Jankowsky, E; Chasin, LA; Nilsen, TW,期刊：Cell, 页码：1224-1236 , 文章类型： Article，,卷期：2008年135-7]
- Alternative splicing makes a major contribution to proteomic diversity in higher eukaryotes with similar to 70% of genes encoding two or more isoforms. In most cases, the molecular mechanisms responsible for splice site ...
- The Structure of the Phage T4 DNA Packaging Motor Suggests a Mechanism Dependent on Electrostatic Forces
[作者：Sun, S; Kondabagil, K; Draper, B; Alam, TI; Bowman, VD; Zhang, Z; Hegde, S; Fokine, A; Rossmann, MG; Rao, VB,期刊：Cell, 页码：1251-1262 , 文章类型： Article，,卷期：2008年135-7]
- Viral genomes are packaged into "procapsids'' by powerful molecular motors. We report the crystal structure of the DNA packaging motor protein, gene product 17 (gp17), in bacteriophage T4. The structure consists of an N-...
- GTPase Cycle of Dynamin Is Coupled to Membrane Squeeze and Release, Leading to Spontaneous Fission
[作者：Bashkirov, PV; Akimov, SA; Evseev, AI; Schmid, SL; Zimmerberg, J; Frolov, VA,期刊：Cell, 页码：1276-1286 , 文章类型： Article，,卷期：2008年135-7]
- The GTPase dynamin is critically involved in membrane fission during endocytosis. How does dynamin use the energy of GTP hydrolysis for membrane remodeling? By monitoring the ionic permeability through lipid nanotubes (N...
- Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts
[作者：Li, P; Tong, C; Mehrian-Shai, R; Jia, L; Wu, N; Yan, Y; Maxson, RE; Schulze, EN; Song, H; Hsieh, CL; Pera, MF; Ying, QL,期刊：Cell, 页码：1299-1310 , 文章类型： Article，,卷期：2008年135-7]
- Rats have important advantages over mice as an experimental system for physiological and pharmacological investigations. The lack of rat embryonic stem (ES) cells has restricted the availability of transgenic technologie...
- Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway
[作者：Hitomi, JI; Christofferson, DE; Ng, A; Yao, JH; Degterev, A; Xavier, RJ; Yuan, JY,期刊：Cell, 页码：1311-1323 , 文章类型： Article，,卷期：2008年135-7]
- Stimulation of death receptors by agonists such as FasL and TNF alpha activates apoptotic cell death in apoptotic-competent conditions or a type of necrotic cell death dependent on RIP1 kinase, termed necroptosis, in apo...
- Capture of Authentic Embryonic Stem Cells from Rat Blastocysts
[作者：Buehr, M; Meek, S; Blair, K; Yang, J; Ure, J; Silva, J; Mclay, R; Hall, J; Ying, QL; Smith, A,期刊：Cell, 页码：1287-1298 , 文章类型： Article，,卷期：2008年135-7]
- Embryonic stem (ES) cells have been available from inbred mice since 1981 but have not been validated for other rodents. Failure to establish ES cells from a range of mammals challenges the identity of cultivated stem ce...
- Networking Opportunities for Bacteria
[作者：Dwyer, DJ; Kohanski, MA; Collins, JJ,期刊：Cell, 页码：1153-1156 , 文章类型： Editorial Material，,卷期：2008年135-7]
- In this post-genomic era, our capacity to explore biological networks and predict network architectures has been greatly expanded, accelerating interest in systems biology. Here, we highlight recent systems biology studi...
- Response The Mitochondrial beta-signal and Protein sorting
[作者：Kutik, S; Stojanovski, D; Becker, T; Stroud, DA; Becker, L; Meinecke, M; Kruger, V; Prinz, C; Guiard, B; Wagner, R; Meisinger, C; Pfanner, N; Wiedemann, N,期刊：Cell, 页码：1159-1160 , 文章类型： Editorial Material，,卷期：2008年135-7]
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- Necroptosis: A Specialized Pathway of Programmed Necrosis
[作者：Galluzzi, L; Kroemer, G,期刊：Cell, 页码：1161-1163 , 文章类型： Editorial Material，,卷期：2008年135-7]
- Necrosis is often viewed as an accidental and unregulated cellular event. However, accumulating evidence suggests that necrosis, like apoptosis, can be executed by regulated mechanisms. Hitomi et al. (2008) now describe ...
- The long and Short of membrane Fission
[作者：Roux, A; Antonny, B,期刊：Cell, 页码：1163-1165 , 文章类型： Editorial Material，,卷期：2008年135-7]
- During membrane fission, the GTPase dynamin forms helical assemblies at the neck of membrane buds. Although it has been proposed that fission results from the constriction of the dynamin helix, new work by Bashkirov et a...
- DNA Cytosine Demethylation: Are We Getting Close?
[作者：Jiricny, J; Menigatti, M,期刊：Cell, 页码：1167-1169 , 文章类型： Editorial Material，,卷期：2008年135-7]
- Whether 5-methylcytosine (meC) can be enzymatically removed from vertebrate DNA has been the subject of extensive study and also some controversy. Rai et al. (2008) now report that cytosine demethylation can be accomplis...
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