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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共36条记录   Regulation of beta-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2 [作者：Whalen, EJ; Foster, MW; Matsumoto, A; Ozawa, K; Violin, JD; Que, LG; Nelson, CD; Benhar, M; Keys, JR; Rockman, HA; Koch, WJ; Daaka, Y; Lefkowitz, RJ; Stamler, JS,期刊：Cell, 页码：20-30 , 文章类型： Article，,卷期：2008年135-2] beta-adrenergic receptors (beta-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein signaling and target re... Phosphorylation-Independent Attenuation of GPCR Signalling [作者：Ferguson, SSG,期刊：Cell, 页码：13-19 , 文章类型： Article，,卷期：2008年135-2] The uncoupling of G-protein-coupled receptors (GPCRs) from their cognate heterotrimeric G proteins provides an essential physiological "feedback" mechanism that protects against both acute and chronic overstimulation of ... Morphine-Induced Receptor Endocytosis in a Novel Knockin Mouse Reduces Tolerance and Dependence [作者：Kim, JA; Bartlett, S; He, L; Nielsen, CK; Chang, AM; Kharazia, V; Waldhoer, M; Ou, CJ; Taylor, S; Ferwerda, M; Cado, D; Whistler, JL,期刊：Cell, 页码：31-38 , 文章类型： Article，,卷期：2008年135-2] Opioid drugs, such as morphine, are among the most effective analgesics available. However, their utility for the treatment of chronic pain is limited by side effects including tolerance and dependence. Morphine acts pri... A beta-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior [作者：Beaulieu, JM; Marion, S; Rodriguiz, RM; Medvedev, IO; Sotnikova, TD; Ghisi, V; Wetsel, WC; Lefkowitz, RJ; Gainetdinov, RR; Caron, MG,期刊：Cell, 页码：39-50 , 文章类型： Article，,卷期：2008年135-2] Besides their role in desensitization, beta-arrestin 1 and 2 promote the formation of signaling complexes allowing G protein-coupled receptors (GPCR) to signal independently from G proteins. Here we show that lithium, a ... Coactivation of G Protein Signaling by Cell-Surface Receptors and an Intracellular Exchange Factor [作者：Lee, MJ; Dohlman, HG,期刊：Cell, 页码：65-70 , 文章类型： Article，,卷期：2008年135-2] G protein-coupled receptors (GPCRs) mediate responses to a broad range of chemical and environmental signals. In yeast, a pheromone-binding GPCR triggers events leading to the fusion of haploid cells. In general, GPCRs f... DEP-Domain-Mediated Regulation of GPCR Signaling Responses [作者：Ballon, DR; Flanary, PL; Gladue, DP; Konopka, JB; Dohlman, HG; Thorner, J,期刊：Cell, 页码：51-64 , 文章类型： Article，,卷期：2008年135-2] G protein-coupled receptors (GPCRs) mediate cellular responses to a variety of stimuli, but how specific responses are regulated has been elusive, as the types of GPCRs vastly outnumber the classes of G protein heterotri... Invitrogen Corporation - Make the Most of Every Cell Foreword [作者：[Anon],期刊：Cell, 页码：1-2 , 文章类型： Editorial Material，,卷期：2008年135-2] Location, Location, Location ... Site-Specific GPCR Phosphorylation Offers a Mechanism for Cell-Type-Specific Signalling [作者：Tobin, AB; Butcher, AJ; Kong, KC,期刊：Cell, 页码：5-12 , 文章类型： Article，,卷期：2008年135-2] It is now established that most of the similar to 800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization an... Molecular Mechanisms of GPCR Regulation [作者：Taylor, D,期刊：Cell, 页码：3-3 , 文章类型： Editorial Material，,卷期：2008年135-2] Hmga2 Promotes Neural Stem Cell Self-Renewal in Young but Not Old Mice by Reducing p16(Ink4a) and p19(Arf) Expression [作者：Nishino, J; Kim, I; Chada, K; Morrison, SJ,期刊：Cell, 页码：227-239 , 文章类型： Article，,卷期：2008年135-2] Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16(Ink4a). We discove... The P-furiosus Mre11/Rad50 Complex Promotes 5 ' Strand Resection at a DNA Double-Strand Break [作者：Hopkins, BB; Paull, TT,期刊：Cell, 页码：250-260 , 文章类型： Article，,卷期：2008年135-2] The Mre11/Rad50 complex has been implicated in the early steps of DNA double-strand break (DSB) repair through homologous recombination in several organisms. However, the enzymatic properties of this complex are incompat... Identification of White Adipocyte Progenitor Cells In Vivo [作者：Rodeheffer, MS; Birsoy, K; Friedman, JM,期刊：Cell, 页码：240-249 , 文章类型： Article，,卷期：2008年135-2] The increased white adipose tissue (WAT) mass associated with obesity is the result of both hyperplasia and hypertrophy of adipocytes. However, the mechanisms controlling adipocyte number are unknown in part because the ... RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination [作者：Barber, LJ; Youds, JL; Ward, JD; McIlwraith, MJ; O'Neil, NJ; Petalcorin, MIR; Martin, JS; Collis, SJ; Cantor, SB; Auclair, M; Tissenbaum, H; West, SC; Rose, AM; Boulton, SJ,期刊：Cell, 页码：261-271 , 文章类型： Article，,卷期：2008年135-2] Homologous recombination (HR) is an important conserved process for DNA repair and ensures maintenance of genome integrity. Inappropriate HR causes gross chromosomal rearrangements and tumorigenesis in mammals. In yeast,... Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation [作者：Duncan, EM; Muratore-Schroeder, TL; Cook, RG; Garcia, BA; Shabanowitz, J; Hunt, DF; Allis, CD,期刊：Cell, 页码：284-294 , 文章类型： Article，,卷期：2008年135-2] Chromatin undergoes developmentally-regulated structural and chemical changes as cells differentiate, which subsequently lead to differences in cellular function by altering patterns of gene expression. To gain insigh... Lid2 Is Required for Coordinating H3K4 and H3K9 Methylation of Heterochromatin and Euchromatin [作者：Li, F; Huarte, M; Zaratiegui, M; Vaughn, MW; Shi, Y; Martienssen, R; Cande, WZ,期刊：Cell, 页码：272-283 , 文章类型： Article，,卷期：2008年135-2] In most eukaryotes, histone methylation patterns regulate chromatin architecture and function: methylation of histone H3 lysine-9 (H3K9) demarcates heterochromatin, whereas H3K4 methylation demarcates euchromatin. We sho... THO/Sub2p Functions to Coordinate 3 '-End Processing with Gene-Nuclear Pore Association [作者：Rougemaille, M; Dieppois, G; Kisseleva-Romanova, E; Gudipati, RK; Lemoine, S; Blugeon, C; Boulay, J; Jensen, TH; Stutz, F; Devaux, F; Libri, D,期刊：Cell, 页码：308-321 , 文章类型： Article，,卷期：2008年135-2] During transcription, proteins assemble sequentially with nascent RNA to generate a messenger ribonucleoprotein particle (mRNP). The THO complex and its associated Sub2p helicase are functionally implicated in both trans...