- Phase I Study of ON 01910.Na, a Novel Modulator of the Polo-Like Kinase 1 Pathway, in Adult Patients With Solid Tumors
[作者:Jimeno, A; Li, J; Messersmith, WA; Laheru, D; Rudek, MA; Maniar, M; Hidalgo, M; Baker, SD; Donehower, RC,期刊:Journal of clinical oncology, 页码:5504-5510 , 文章类型: Article,,卷期:2008年26-34]
- PurposeWe conducted a first-in-man (to our knowledge) phase I study to determine the dose-limiting toxicities (DLTs), characterize the pharmacokinetic profile, and document any antitumor activity of ON 01910.Na, a new ch...
- Prognostic and Predictive Value of Centrally Reviewed Ki-67 Labeling Index in Postmenopausal Women With Endocrine-Responsive Breast Cancer: Results From Breast International Group Trial 1-98 Comparing Adjuvant Tamoxifen With Letrozole
[作者:Viale, G; Giobbie-Hurder, A; Regan, MM; Coates, AS; Mastropasqua, MG; Dell'Orto, P; Maiorano, E; MacGrogan, G; Braye, SG; Ohlschlegel, C; Neven, P; Orosz, Z; Olszewski, WP; Knox, F; Thurlimann, B; Price, KN; Castiglione-Gertsch, M; Gelber, RD; Gusterson, BA; Goldhirsch, A,期刊:Journal of clinical oncology, 页码:5569-5575 , 文章类型: Article,,卷期:2008年26-34]
- Purpose To evaluate the prognostic and predictive value of Ki-67 labeling index (LI) in a trial comparing letrozole (Let) with tamoxifen (Tam) as adjuvant therapy in postmenopausal women with early breast cancer.Patients...
- Body-Mass Index and Progression of Hepatitis B: A Population-Based Cohort Study in Men
[作者:Yu, MW; Shih, WL; Lin, CL; Liu, CJ; Jian, JW; Tsai, KS; Chen, CJ,期刊:Journal of clinical oncology, 页码:5576-5582 , 文章类型: Article,,卷期:2008年26-34]
- PurposeTo determine prospectively whether body-mass index (BMI) is associated with liver-related morbidity and mortality among male hepatitis B virus (HBV) carriers.Patients and MethodsWe performed a prospective study of...
- Randomized, Phase II Study of the Thrombospondin-1-Mimetic Angiogenesis Inhibitor ABT-510 in Patients With Advanced Soft Tissue Sarcoma
[作者:Baker, LH; Rowinsky, EK; Mendelson, D; Humerickhouse, RA; Knight, RA; Qian, J; Carr, RA; Gordon, GB; Demetri, GD,期刊:Journal of clinical oncology, 页码:5583-5588 , 文章类型: Article,,卷期:2008年26-34]
- PurposeSarcomas are among the most proangiogenic malignancies in preclinical models. Phase I study results for ABT-510, which inhibits angiogenesis via a novel thrombospondin-mimetic mechanism, suggested activity in soft...
- Recommendations for Collection and Handling of Specimens From Group Breast Cancer Clinical Trials
[作者:Leyland-Jones, BR; Ambrosone, CB; Bartlett, J; Ellis, MJC; Enos, RA; Raji, A; Pins, MR; Zujewski, JA; Hewitt, SM; Forbes, JF; Abramovitz, M; Braga, S; Cardoso, F; Harbeck, N; Denkert, C; Jewell, SD,期刊:Journal of clinical oncology, 页码:5638-5644 , 文章类型: Article,,卷期:2008年26-34]
- Recommendations for specimen collection and handling have been developed for adoption across breast cancer clinical trials conducted by the Breast International Group (BIG)-sponsored Groups and the National Cancer Instit...
- Temsirolimus in Patients With Renal Cancer on Hemodialysis
[作者:Lunardi, G; Vannozzi, MO; Armirotti, A; Nicodemo, M; Venturini, M; Cavallini, L,期刊:Journal of clinical oncology, 页码:5652-U182 , 文章类型: Letter,,卷期:2008年26-34]
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