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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共13条记录   Risky business [作者：ANONYMOUS,期刊：NATURE CHEMICAL BIOLOGY, 页码：1-1 , 文章类型： Editorial Material，,卷期：2013年9-1] PROTEIN ENGINEERING Making ubiquitin specific [作者：SIXMA TITIA K,期刊：NATURE CHEMICAL BIOLOGY, 页码：10-11 , 文章类型： News Item，,卷期：2013年9-1] ENZYMEs Nailing down hydrogenase [作者：MARONEY MICHAEL J,期刊：NATURE CHEMICAL BIOLOGY, 页码：11-12 , 文章类型： News Item，,卷期：2013年9-1] PROTEIN FOLDING Salty sea regulators of cystic fibrosis [作者：GUPTA VIJAY; BALCH WILLIAM E,期刊：NATURE CHEMICAL BIOLOGY, 页码：12-14 , 文章类型： News Item，,卷期：2013年9-1] O-2-independent formation of the inactive states of NiFe hydrogenase [作者：ABOU HAMDAN ABBAS; BURLAT BENEDICTE; GUTIERREZSANZ OSCAR; LIEBGOTT PIERREPOL; BAFFERT CAROLE; DE LACEY ANTONIO L; ROUSSET MARC; GUIGLIARELLI BRUNO; LEGER CHRISTOPHE; DEMENTIN SEBASTIEN,期刊：NATURE CHEMICAL BIOLOGY, 页码：15-+ , 文章类型： Article，,卷期：2013年9-1] We studied the mechanism of aerobic inactivation of Desulfovibrio fructosovorans nickel-iron (NiFe) hydrogenase by quantitatively examining the results of electrochemistry, EPR and FTIR experiments. They suggest that, co... RNA SHAPE analysis in living cells [作者：SPITALE ROBERT C; CRISALLI PETE; FLYNN RYAN A; TORRE EDUARDO A; KOOL ERIC T; CHANG HOWARD Y,期刊：NATURE CHEMICAL BIOLOGY, 页码：18-+ , 文章类型： Article，,卷期：2013年9-1] RNA structure has important roles in practically every facet of gene regulation, but the paucity of in vivo structural probes limits current understanding. Here we design, synthesize and demonstrate two new chemical prob... Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion [作者：BAUER RENATO A; WENDERSKI TODD A; TAN DEREK S,期刊：NATURE CHEMICAL BIOLOGY, 页码：21-+ , 文章类型： Article，,卷期：2013年9-1] Nature has exploited medium-sized 8- to 11-membered rings in a variety of natural products to address diverse and challenging biological targets. However, owing to the limitations of conventional cyclization-based approa... A public-private partnership to unlock the untargeted kinome [作者：KNAPP STEFAN; ARRUDA PAULO; BLAGG JULIAN; BURLEY STEPHEN; DREWRY DAVID H; EDWARDS ALED; FABBRO DORIANO; GILLESPIE PAUL; GRAY NATHANAEL S; KUSTER BERNHARD; LACKEY KAREN E; MAZZAFERA PAULO; TOMKINSON NICHOLAS C O; WILLSON TIMOTHY M; WORKMAN PAUL; ZUERCHER WILLIAM J,期刊：NATURE CHEMICAL BIOLOGY, 页码：3-7 , 文章类型： Editorial Material，,卷期：2013年9-1] Identification of DES1 as a vitamin A isomerase in Muller glial cells of the retina [作者：KAYLOR JOANNA J; YUAN QUAN; COOK JEREMY; SARFARE SHANTA; MAKSHANOFF JACOB; MIU ANH; KIM ANITA; KIM PAUL; HABIB SAMER; ROYBAL C NATHANIEL; XU TONGZHOU; NUSINOWITZ STEVEN; TRAVIS GABRIEL H,期刊：NATURE CHEMICAL BIOLOGY, 页码：30-+ , 文章类型： Article，,卷期：2013年9-1] Absorption of a light particle by an opsin-pigment causes photoisomerization of its retinaldehyde chromophore. Restoration of light sensitivity to the resulting apo-opsin requires chemical re-isomerization of the photobl... Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba [作者：MICHALEK MATTHIAS; SOENNICHSEN FRANK D; WECHSELBERGER RAINER; DINGLEY ANDREW J; HUNG CHIENWEN; KOPP ANNIKA; WIENK HANS; SIMANSKI MAREN; HERBST ROSA; LORENZEN INKEN; MARCIANOCABRAL FRANCINE; GELHAUS CHRISTOPH; GUTSMANN THOMAS; THOLEY ANDREAS; GROETZINGER JOACHIM; LEIPPE MATTHIAS,期刊：NATURE CHEMICAL BIOLOGY, 页码：37-+ , 文章类型： Article，,卷期：2013年9-1] Human pathogens often produce soluble protein toxins that generate pores inside membranes, resulting in the death of target cells and tissue damage. In pathogenic amoebae, this has been exemplified with amoebapores of th... Active site profiling reveals coupling between domains in SRC-family kinases [作者：KRISHNAMURTY RATIKA; BRIGHAM JENNIFER L; LEONARD STEPHEN E; RANJITKAR PRATISTHA; LARSON ERIC T; DALE EDWARD J; MERRITT ETHAN A; MALY DUSTIN J,期刊：NATURE CHEMICAL BIOLOGY, 页码：43-+ , 文章类型： Article，,卷期：2013年9-1] Protein kinases, key regulators of intracellular signal transduction, have emerged as an important class of drug targets. Chemical proteomic tools that facilitate the functional interrogation of protein kinase active sit... Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7 [作者：ZHANG YINGNAN; ZHOU LIJUAN; ROUGE LIONEL; PHILLIPS AARON H; LAM CYNTHIA; LIU PETER; SANDOVAL WENDY; HELGASON ELIZABETH; MURRAY JEREMY M; WERTZ INGRID E; CORN JACOB E,期刊：NATURE CHEMICAL BIOLOGY, 页码：51-+ , 文章类型： Article，,卷期：2013年9-1] Protein conformation and function are often inextricably linked, such that the states a protein adopts define its enzymatic activity or its affinity for various partners. Here we combine computational design with macromo... Peptidomic discovery of short open reading frame-encoded peptides in human cells [作者：SLAVOFF SARAH A; MITCHELL ANDREW J; SCHWAID ADAM G; CABILI MORAN N; MA JIAO; LEVIN JOSHUA Z; KARGER AMIR D; BUDNIK BOGDAN A; RINN JOHN L; SAGHATELIAN ALAN,期刊：NATURE CHEMICAL BIOLOGY, 页码：59-+ , 文章类型： Article，,卷期：2013年9-1] The complete extent to which the human genome is translated into polypeptides is of fundamental importance. We report a peptidomic strategy to detect short open reading frame (sORF)-encoded polypeptides (SEPs) in human c...