- Steroidogenic Acute Regulatory Protein Has a More Open Conformation Than the Independently Folded Smaller Subdomains
[作者:Bose, HS; Whittal, RM; Debnath, D; Bose, M,期刊:Biochemistry, 页码:11630-11639 , 文章类型: Article,,卷期:2009年48-49]
- The acute steroidogenic response, which produces steroids in response to stress, requires the steroidogenic acute regulatory protein (StAR). StAR, a mitochondrial matrix protein, acts on the outer mitochondrial membrane ...
- Metal Binding Affinities of Arabidopsis Zinc and Copper Transporters: Selectivities Match the Relative, but Not the Absolute, Affinities of their Amino-Terminal Domains
[作者:Zimmermann, M; Clarke, O; Gulbis, JM; Keizer, DW; Jarvis, RS; Cobbett, CS; Hinds, MG; Xiao, ZG; Weddl, AG,期刊:Biochemistry, 页码:11640-11654 , 文章类型: Article,,卷期:2009年48-49]
- HMA2, HMA4, and HMA7 are three of the eight heavy metal transporting P-IB-type ATPases in the simple plant Arabidopsis thaliana. The first two transport Zn2+, and the third transports Cu+. Each protein contains soluble N...
- The Heparin Binding Motif of Endostatin Mediates Its Interaction with Receptor Nucleolin
[作者:Fu, Y; Chen, Y; Luo, X; Liang, Y; Shi, HB; Gao, L; Zhan, SL; Zhou, DF; Luo, YZ,期刊:Biochemistry, 页码:11655-11663 , 文章类型: Article,,卷期:2009年48-49]
- Endostatin is a potent angiogenesis inhibitor with heparin-dependent activities. Nucleolin, a novel functional receptor of endostatin, mediates both the internalization to endothelial cells and the antiangiogenic activit...
- Distinct Pose of Discodermolide in Taxol Binding Pocket Drives a Complementary Mode of Microtubule Stabilization
[作者:Khrapunovich-Baine, M; Menon, V; Verdier-Pinard, P; Smith, AB; Angeletti, RH; Fiser, A; Horwitz, SB; Xiao, H,期刊:Biochemistry, 页码:11664-11677 , 文章类型: Article,,卷期:2009年48-49]
- The microtubule cytoskeleton has proven to be an effective target for cancer therapeutics. One class of drugs, known as microtubule stabilizing agents (MSAs), binds to microtubule polymers and stabilizes them against dep...
- The Major Surface Carbohydrates of the Echinococcus granulosus Cyst: Mucin-Type O-Glycans Decorated by Novel Galactose-Based Structures
[作者:Diaz, A; Fontana, EC; Todeschini, AR; Soule, S; Gonzalez, H; Casaravilla, C; Portela, M; Mohana-Borges, R; Mendonca-Previato, L; Previato, JO; Ferreira, F,期刊:Biochemistry, 页码:11678-11691 , 文章类型: Article,,卷期:2009年48-49]
- The cestodes constitute important but understudied human and veterinary parasites. Their surfaces are rich in carbohydrates, on which very little structural information is available. The tissue-dwelling larva (hydatid cy...
- Dissociation Kinetics of the GroEL-gp31 Chaperonin Complex Studied with Forster Resonance Energy Transfer
[作者:Calmat, S; Hendriks, J; van Heerikhuizen, H; Schmidt, CF; van der Vies, SM; Peterman, EJG,期刊:Biochemistry, 页码:11692-11698 , 文章类型: Article,,卷期:2009年48-49]
- Propagation of bacteriophage T4 in its host Escherichia coli involves the folding of the major capsid protein gp23, which is facilitated by a hybrid chaperone complex consisting of the bacterial chaperonin GroEL and the ...
- Interaction between Na+ Ion and Carboxylates of the PomA-PomB Stator Unit Studied by ATR-FTIR Spectroscopy
[作者:Sudo, Y; Kitade, Y; Furutani, Y; Kojima, M; Kojima, S; Homma, M; Kandori, H,期刊:Biochemistry, 页码:11699-11705 , 文章类型: Article,,卷期:2009年48-49]
- Bacterial flagellar motors are molecular machines powered by the electrochemical potential gradient of specific ions across the membrane. The PomA-PomB stator complex of Vibrio alginolyticus couples Na+ influx to torque ...
- Evidence of Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions
[作者:Jackson, SG; Zhang, FZ; Chindemi, P; Junop, MS; Berti, PJ,期刊:Biochemistry, 页码:11715-11723 , 文章类型: Article,,卷期:2009年48-49]
- MurA (enolpyruvyl UDP-GlcNAc synthase) catalyzes the first committed step in peptidoglycan biosynthesis. In this study, MurA-catalyzed breakdown of its tetrahedral intermediate (THI), with a k(cat)/K-M of 520 M-1 s(-1), ...
- Physical Instability of a Therapeutic Fc Fusion Protein: Domain Contributions to Conformational and Colloidal Stability
[作者:Fast, JL; Cordes, AA; Carpenter, JF; Randolph, TW,期刊:Biochemistry, 页码:11724-11736 , 文章类型: Article,,卷期:2009年48-49]
- Protein therapeutics made up of artificially combined proteins or protein domains, so-called fusion proteins, are a novel and growing class of biopharmaceuticals. We have studied abatacept (Orencia), a fusion protein tha...
- Betaglycan has Two Independent Domains Required for High Affinity TGF-beta Binding: Proteolytic Cleavage Separates the Domains and Inactivates the Neutralizing Activity of the Soluble Receptor
[作者:Mendoza, V; Vilchis-Landeros, MM; Mendoza-Hernandez, G; Huang, T; Villarreal, MM; Hinck, AP; Lopez-Casillas, F; Montiel, JL,期刊:Biochemistry, 页码:11755-11765 , 文章类型: Article,,卷期:2009年48-49]
- Betaglycan is a coreceptor for members of the transforming growth factor beta (TGF-beta) superfamily. Mutagenesis has identified two ligand binding regions, one at the membrane-distal and the other at the membrane-proxim...
- Molecular Basis of Association of Receptor Activity-Modifying Protein 3 with the Family B G Protein-Coupled Secretin Receptor
[作者:Harikumar, KG; Simms, J; Christopoulos, G; Sexton, PM; Miller, LJ,期刊:Biochemistry, 页码:11773-11785 , 文章类型: Article,,卷期:2009年48-49]
- The three receptor activity-modifying proteins (RAMPS) have been recognized as being important for the trafficking and function of a subset of family B G protein-coupled receptors, although the structural basis for this ...
- Phosphorylation of Serine 205 by the Protein Kinase CK2 Persists on Pax3-FOXO1, but Not Pax3, throughout Early Myogenic Differentiation
[作者:Dietz, KN; Miller, PJ; Hollenbach, AD,期刊:Biochemistry, 页码:11786-11795 , 文章类型: Article,,卷期:2009年48-49]
- The myogenic transcription factor Pax3 plays an essential role in early skeletal muscle development and is a key component in alveolar rhabdomyosarcoma (ARMS), a childhood solid muscle tumor. ARMS is characterized by a t...
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