- Genetic Reevaluation of the Role of F-Box Proteins in Cyclin D1 Degradation
[作者:Kanie, T; Onoyama, I; Matsumoto, A; Yamada, M; Nakatsumi, H; Tateishi, Y; Yamamura, S; Tsunematsu, R; Matsumoto, M; Nakayama, KI,期刊:Molecular and Cellular Biology, 页码:590-605 , 文章类型: Article,,卷期:2012年32-3]
- D-type cyclins play a pivotal role in G(1)-S progression of the cell cycle, and their expression is frequently deregulated in cancer. Cyclin D1 has a half-life of only similar to 30 min as a result of its ubiquitylation ...
- A Novel Function of p38-Regulated/Activated Kinase in Endothelial Cell Migration and Tumor Angiogenesis
[作者:Yoshizuka, N; Chen, RM; Xu, Z; Liao, R; Hong, LX; Hu, WY; Yu, GL; Han, JH; Chen, LC; Sun, PQ,期刊:Molecular and Cellular Biology, 页码:606-618 , 文章类型: Article,,卷期:2012年32-3]
- The p38 mitogen-activated protein kinase (MAPK) pathway has been implicated in both suppression and promotion of tumorigenesis. It remains unclear how these 2 opposite functions of p38 operate in vivo to impact cancer de...
- Dopamine-Regulated MicroRNA MiR-181a Controls GluA2 Surface Expression in Hippocampal Neurons
[作者:Saba, R; Storchel, PH; Aksoy-Aksel, A; Kepura, F; Lippi, G; Plant, TD; Schratt, GM,期刊:Molecular and Cellular Biology, 页码:619-632 , 文章类型: Article,,卷期:2012年32-3]
- The dynamic expression of AMPA-type glutamate receptors (AMPA-R) at synapses is a key determinant of synaptic plasticity, including neuroadaptations to drugs of abuse. Recently, microRNAs (miRNAs) have emerged as importa...
- MicroRNA-200c Represses Migration and Invasion of Breast Cancer Cells by Targeting Actin-Regulatory Proteins FHOD1 and PPM1F
[作者:Jurmeister, S; Baumann, M; Balwierz, A; Keklikoglou, I; Ward, A; Uhlmann, S; Zhang, JD; Wiemann, S; Sahin, O,期刊:Molecular and Cellular Biology, 页码:633-651 , 文章类型: Article,,卷期:2012年32-3]
- MicroRNA-200c (miR-200c) has been shown to suppress epithelial-mesenchymal transition (EMT), which is attributed mainly to targeting of ZEB1/ZEB2, repressors of the cell-cell contact protein E-cadherin. Here we demonstra...
- The Laforin-Malin Complex Negatively Regulates Glycogen Synthesis by Modulating Cellular Glucose Uptake via Glucose Transporters
[作者:Singh, PK; Singh, S; Ganesh, S,期刊:Molecular and Cellular Biology, 页码:652-663 , 文章类型: Article,,卷期:2012年32-3]
- Lafora disease (LD), an inherited and fatal neurodegenerative disorder, is characterized by increased cellular glycogen content and the formation of abnormally branched glycogen inclusions, called Lafora bodies, in the a...
- Remodelers Organize Cellular Chromatin by Counteracting Intrinsic Histone-DNA Sequence Preferences in a Class-Specific Manner
[作者:Moshkin, YM; Chalkley, GE; Kan, TW; Reddy, BA; Ozgur, Z; van Ijcken, WFJ; Dekkers, DHW; Demmers, JA; Travers, AA; Verrijzer, CP,期刊:Molecular and Cellular Biology, 页码:675-688 , 文章类型: Article,,卷期:2012年32-3]
- The nucleosome is the fundamental repeating unit of eukaryotic chromatin. Here, we assessed the interplay between DNA sequence and ATP-dependent chromatin-remodeling factors (remodelers) in the nucleosomal organization o...
- Conserved Molecular Interactions within the HBO1 Acetyltransferase Complexes Regulate Cell Proliferation
[作者:Avvakumov, N; Lalonde, ME; Saksouk, N; Paquet, E; Glass, KC; Landry, AJ; Doyon, Y; Cayrou, C; Robitaille, GA; Richard, DE; Yang, XJ; Kutateladze, TG; Cote, J,期刊:Molecular and Cellular Biology, 页码:689-703 , 文章类型: Article,,卷期:2012年32-3]
- Acetyltransferase complexes of the MYST family with distinct substrate specificities and functions maintain a conserved association with different ING tumor suppressor proteins. ING complexes containing the HBO1 acetylas...
- A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes
[作者:Shah, ZH; Ahmed, SU; Ford, JR; Allison, SJ; Knight, JRP; Milner, J,期刊:Molecular and Cellular Biology, 页码:704-716 , 文章类型: Article,,卷期:2012年32-3]
- SIRT1 is an NAD-dependent deacetylase and epigenetic regulator essential for normal mammalian development and homeostasis. Here we describe a human SIRT1 splice variant, designated SIRT1-Delta 2/9, in which the deacetyla...
- Rhythmic Interaction between Period1 mRNA and hnRNP Q Leads to Circadian Time-Dependent Translation
[作者:Lee, KH; Woo, KC; Kim, DY; Kim, TD; Shin, J; Park, SM; Jang, SK; Kim, KT,期刊:Molecular and Cellular Biology, 页码:717-728 , 文章类型: Article,,卷期:2012年32-3]
- The mouse PERIOD1 (mPER1) protein, along with other clock proteins, plays a crucial role in the maintenance of circadian rhythms. mPER1 also provides an important link between the circadian system and the cell cycle syst...
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