- Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling
[作者：Reddy, NM; Kleeberger, SR; Bream, JH; Fallon, PG; Kensler, TW; Yamamoto, M; Reddy, SP,期刊：Oncogene, 页码：5821-5832 , 文章类型： Article，,卷期：2008年27-44]
- Genetic disruption of Nrf2 greatly enhances susceptibility to prooxidant- and carcinogen-induced experimental models of various human disorders; but the mechanisms by which this transcription factor confers protection ar...
- Notch-1 associates with IKK alpha and regulates IKK activity in cervical cancer cells
[作者：Song, LL; Peng, Y; Yun, J; Rizzo, P; Chaturvedi, V; Weijzen, S; Kast, WM; Stone, PJB; Santos, L; Loredo, A; Lendahl, U; Sonenshein, G; Osborne, B; Qin, JZ; Pannuti, A; Nickoloff, BJ; Miele, L,期刊：Oncogene, 页码：5833-5844 , 文章类型： Article，,卷期：2008年27-44]
- Notch-1 inhibits apoptosis in some transformed cells through incompletely understood mechanisms. Notch-1 can increase nuclear factor-kappa B (NF-kappa B) activity through a variety of mechanisms. Overexpression of cleave...
- PCAF is an HIF-1 alpha cofactor that regulates p53 transcriptional activity in hypoxia
[作者：Xenaki, G; Ontikatze, T; Rjaendran, R; Startford, IJ; Drive, C; Krstic-Demonacos, M; Demonacos, C,期刊：Oncogene, 页码：5785-5796 , 文章类型： Article，,卷期：2008年27-44]
- The p53 tumour suppressor is involved in several crucial cellular functions including cell-cycle arrest and apoptosis. p53 stabilization occurs under hypoxic and DNA damage conditions. However, only in the latter scenari...
- Molecular association between beta-catenin degradation complex and Rac guanine exchange factor DOCK4 is essential for Wnt/beta-catenin signaling
[作者：Upadhyay, G; Goessling, W; North, TE; Xavier, R; Zon, LI; Yajnik, V,期刊：Oncogene, 页码：5845-5855 , 文章类型： Article，,卷期：2008年27-44]
- The canonical Wnt/beta-catenin pathway is a highly conserved signaling cascade that is involved in development and stem cell renewal. The deregulation of this pathway is often associated with increased cell growth and ne...
- Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival
[作者：Wotton, S; Terry, A; Kilbey, A; Jenkins, A; Herzyk, P; Cameron, E; Neil, JC,期刊：Oncogene, 页码：5856-5866 , 文章类型： Article，,卷期：2008年27-44]
- The Runx genes are important in development and cancer, where they can act either as oncogenes or tumour suppressors. We compared the effects of ectopic Runx expression in established fibroblasts, where all three genes p...
- CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases
[作者：Bettayeb, K; Oumata, N; Echalier, A; Ferandin, Y; Endicott, JA; Galons, H; Meijer, L,期刊：Oncogene, 页码：5797-5807 , 文章类型： Article，,卷期：2008年27-44]
- Among the ten pharmacological inhibitors of cyclin-dependent kinases (CDKs) currently in clinical trials, the purine roscovitine (CYC202, Seliciclib) is undergoing phase 2 trials against non-small-cell lung and nasophary...
- Recruitment of adenomatous polyposis coli and beta-catenin to axin-puncta
[作者：Faux, MC; Coates, JL; Catimel, B; Cody, S; Clayton, AHA; Layton, MJ; Burgess, AW,期刊：Oncogene, 页码：5808-5820 , 文章类型： Article，,卷期：2008年27-44]
- The adenomatous polyposis coli (APC) tumour suppressor is a multifunctional protein involved in the regulation of Wnt signalling and cytoskeletal dynamics. Little is known about how APC controls these disparate functions...
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