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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Bcl-2 family proteins and cancer [作者：Yip, KW; Reed, JC,期刊：Oncogene, 页码：6398-6406 , 文章类型： Review，,卷期：2008年27-50] BCL-2 was the first anti-death gene discovered, a milestone with far reaching implications for tumor biology. Multiple members of the human Bcl-2 family of apoptosis-regulating proteins have been identified, including si... Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis [作者：Pinton, P; Giorgi, C; Siviero, R; Zecchini, E; Rizzuto, R,期刊：Oncogene, 页码：6407-6418 , 文章类型： Review，,卷期：2008年27-50] There is a growing consensus that the various forms of cell death ( necrosis, apoptosis and autophagy) are not separated by strict boundaries, but rather share molecular effectors and signaling routes. Among the latter, ... The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family [作者：Heath-Engel, HM; Chang, NC; Shore, GC,期刊：Oncogene, 页码：6419-6433 , 文章类型： Review，,卷期：2008年27-50] Apoptosis is essential for normal development and maintenance of homeostasis, and disruption of apoptotic pathways is associated with multiple disease states, including cancer. Although initially identified as central re... Lysosomal membrane permeabilization in cell death [作者：Boya, P; Kroemer, G,期刊：Oncogene, 页码：6434-6451 , 文章类型： Review，,卷期：2008年27-50] Mitochondrial outer membrane permeabilization ( MOMP) constitutes one of the major checkpoint(s) of apoptotic and necrotic cell death. Recently, the permeabilization of yet another organelle, the lysosome, has been shown... Caspase-independent cell death: leaving the set without the final cut [作者：Tait, SWG; Green, DR,期刊：Oncogene, 页码：6452-6461 , 文章类型： Review，,卷期：2008年27-50] Apoptosis is dependent upon caspase activation leading to substrate cleavage and, ultimately, cell death. Although required for the apoptotic phenotype, it has become apparent that cells frequently die even when caspase ... Apoptotic signaling by c-MYC [作者：Hoffman, B; Liebermann, DA,期刊：Oncogene, 页码：6462-6472 , 文章类型： Review，,卷期：2008年27-50] c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes cells to apoptosis by a variety of stimuli. Th... PI3K/Akt: getting it right matters [作者：Franke, TF,期刊：Oncogene, 页码：6473-6488 , 文章类型： Review，,卷期：2008年27-50] The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical signaling molecule within eukaryotic cells. Significant progress has been made in clarifying its regulation by upstream kinases and... Molecular chaperones as regulators of cell death [作者：Hishiya, A; Takayama, S,期刊：Oncogene, 页码：6489-6506 , 文章类型： Review，,卷期：2008年27-50] Molecular chaperones have been reported as multifunctional antistress molecules that can regulate diverse biological processes to maintain cellular homeostasis. Molecular chaperones have critical roles for maintaining pr... The p53 family and programmed cell death [作者：Pietsch, EC; Sykes, SM; McMahon, SB; Murphy, ME,期刊：Oncogene, 页码：6507-6521 , 文章类型： Review，,卷期：2008年27-50] The p53 tumor suppressor continues to hold distinction as the most frequently mutated gene in human cancer. The ability of p53 to induce programmed cell death, or apoptosis, of cells exposed to environmental or oncogenic... Nucleoside analogs: molecular mechanisms signaling cell death [作者：Ewald, B; Sampath, D; Plunkett, W,期刊：Oncogene, 页码：6522-6537 , 文章类型： Review，,卷期：2008年27-50] Nucleoside analogs are structurally similar antimetabolites that have a broad range of action and are clinically active in both solid tumors and hematological malignancies. Many of these agents are incorporated into DNA ...