- Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures
[作者：Brellier, F; Bergoglio, V; Valin, A; Barnay, S; Chevallier-Lagente, O; Vielh, P; Spatz, A; Gorry, P; Avril, MF; Magnaldo, T,期刊：Oncogene, 页码：6601-6606 , 文章类型： Article，,卷期：2008年27-51]
- Basal cell carcinoma of the skin is the most common type of cancer in humans. The majority of these tumors displays aberrant activation of the SONIC HEDGEHOG (SHH)/PATCHED pathway, triggered by mutations in the PATCHED t...
- Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays
[作者：Rickman, DS; Millon, R; De Reynies, A; Thomas, E; Wasylyk, C; Muller, D; Abecassis, J; Wasylyk, B,期刊：Oncogene, 页码：6607-6622 , 文章类型： Article，,卷期：2008年27-51]
- Propensity for subsequent distant metastasis in head and neck squamous-cell carcinoma (HNSCC) was analysed using 186 primary tumours from patients initially treated by surgery that developed ( M) or did not develop (NM) ...
- Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity
[作者：De Luca, M; Brunetto, L; Asteriti, IA; Giubettini, M; Lavia, P; Guarguaglini, G,期刊：Oncogene, 页码：6539-6549 , 文章类型： Article，,卷期：2008年27-51]
- Mitotic spindle assembly is a highly regulated process, crucial to ensure the correct segregation of duplicated chromosomes in daughter cells and to avoid aneuploidy, a common feature of tumors. Among the most important ...
- PDGFR-A is a therapeutic target in alveolar rhabdomyosarcoma
[作者：Taniguchi, E; Nishijo, K; McCleish, AT; Michalek, JE; Grayson, MH; Infante, AJ; Abboud, HE; Legallo, RD; Qualman, SJ; Rubin, BP; Keller, C,期刊：Oncogene, 页码：6550-6560 , 文章类型： Article，,卷期：2008年27-51]
- Alveolar rhabdomyosarcoma is an aggressive skeletal muscle cancer of childhood. Our initial studies of rhabdomyosarcoma gene expression for patients enrolled in a national clinical trial suggested that platelet-derived g...
- E2f3a and E2f3b make overlapping but different contributions to total E2f3 activity
[作者：Danielian, PS; Friesenhahn, LB; Faust, AM; West, JC; Caron, AM; Bronson, RT; Lees, JA,期刊：Oncogene, 页码：6561-6570 , 文章类型： Article，,卷期：2008年27-51]
- The E2f transcription factors are key downstream targets of the retinoblastoma protein tumor suppressor that control cell proliferation. E2F3 has garnered particular attention because it is amplified in various human tum...
- PRIMA-1(MET) induces mitochondrial apoptosis through activation of caspase-2
[作者：Shen, J; Vakifahmetoglu, H; Stridh, H; Zhivotovsky, B; Wiman, KG,期刊：Oncogene, 页码：6571-6580 , 文章类型： Article，,卷期：2008年27-51]
- p53 mutations occur frequently in human tumors. The low-molecular-weight compound PRIMA-1(MET) reactivates mutant p53, induces apoptosis in human tumor cells and inhibits tumor xenograft growth in vivo. Here, we show tha...
- Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3B
[作者：Koyama, N; Zhang, J; Huqun; Miyazawa, H; Tanaka, T; Su, X; Hagiwara, K,期刊：Oncogene, 页码：6581-6589 , 文章类型： Article，,卷期：2008年27-51]
- SEMA3B, a member of class 3 semaphorins, is a tumor suppressor. Competition with vascular endothelial growth factor ( VEGF)(165) explains a portion of the activity, whereas the VEGF-independent mechanism was not elucidat...
- Acid sphingomyelinase deficiency protects from cisplatin-induced gastrointestinal damage
[作者：Rebillard, A; Rioux-Leclercq, N; Muller, C; Bellaud, P; Jouan, F; Meurette, O; Jouan, E; Vernhet, L; Le Quement, C; Carpinteiro, A; Schenck, M; Lagadic-Gossmann, D; Gulbins, E; Dimanche-Boitrel, MT,期刊：Oncogene, 页码：6590-6595 , 文章类型： Article，,卷期：2008年27-51]
- Cisplatin is one of the most effectively used chemotherapeutic agents for cancer treatment. However, in humans, important cytotoxic side effects are observed including dose-limiting renal damage and profound gastrointest...
- Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background
[作者：Mao, JH; Wu, D; DelRosario, R; Castellanos, A; Balmain, A; Perez-Losada, J,期刊：Oncogene, 页码：6596-6600 , 文章类型： Article，,卷期：2008年27-51]
- Ataxia-Telangiectasia (A-T) is an autosomal recessive human disease characterized by genetic instability, radiosensitivity, immunodeficiency and cancer predisposition, because of mutation in both alleles of the ATM (atax...
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