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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共15条记录   Cell polarity proteins: common targets for tumorigenic human viruses [作者：Javier, RT,期刊：Oncogene, 页码：7031-7046 , 文章类型： Review，,卷期：2008年27-55] Loss of polarity and disruption of cell junctions are common features of epithelial-derived cancer cells, and mounting evidence indicates that such defects have a direct function in the pathology of cancer. Supporting th... Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA [作者：Hatakeyama, M,期刊：Oncogene, 页码：7047-7054 , 文章类型： Review，,卷期：2008年27-55] Loss of cell polarity and tissue architecture is a hallmark of carcinomas that arise from epithelial cells. Recent studies on Drosophila tumor suppressors have provided evidence that epithelial polarity and cell prolifer... Par complex in cancer: a regulator of normal cell polarity joins the dark side [作者：Aranda, V; Nolan, ME; Muthuswamy, SK,期刊：Oncogene, 页码：6878-6887 , 文章类型： Review，,卷期：2008年27-55] In the past 20 years, the discovery and characterization of the molecular machinery that controls cellular polarization have enabled us to achieve a better understanding of many biological processes. Spatial asymmetry or... On the guardians of polarity and the disorientation of cancer INTRODUCTION [作者：Banks, L; Humbert, PO,期刊：Oncogene, 页码：6876-6877 , 文章类型： Editorial Material，,卷期：2008年27-55] Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module [作者：Humbert, PO; Grzeschik, NA; Brumby, AM; Galea, R; Elsum, I; Richardson, HE,期刊：Oncogene, 页码：6888-6907 , 文章类型： Review，,卷期：2008年27-55] The neoplastic tumour suppressors, Scribble, Dlg and Lgl, originally discovered in the vinegar fly Drosophila melanogaster, are currently being actively studied for their potential role in mammalian tumourigenesis. In Dr... LKB1; linking cell structure and tumor suppression [作者：Hezel, AF; Bardeesy, N,期刊：Oncogene, 页码：6908-6919 , 文章类型： Review，,卷期：2008年27-55] Germ line mutations in the LKB1 tumor suppressor gene are associated with the Peutz-Jeghers polyposis and cancer syndrome. Somatic mutations in Lkb1 are observed in sporadic pulmonary, pancreatic and biliary cancers and ... Cadherins and cancer: how does cadherin dysfunction promote tumor progression? [作者：Jeanes, A; Gottardi, CJ; Yap, AS,期刊：Oncogene, 页码：6920-6929 , 文章类型： Review，,卷期：2008年27-55] It has long been recognized that the cell-cell adhesion receptor, E-cadherin, is an important determinant of tumor progression, serving as a suppressor of invasion and metastasis in many contexts. Yet how the loss of E-c... Tight junction-based epithelial microenvironment and cell proliferation [作者：Tsukita, S; Yamazaki, Y; Katsuno, T; Tamura, A; Tsukita, S,期刊：Oncogene, 页码：6930-6938 , 文章类型： Review，,卷期：2008年27-55] Belt-like tight junctions (TJs), referred to as zonula occludens, have long been regarded as a specialized differentiation of epithelial cell membranes. They are required for cell adhesion and paracellular barrier functi... The epithelial polarity program: machineries involved and their hijacking by cancer [作者：Tanos, B; Rodriguez-Boulan, E,期刊：Oncogene, 页码：6939-6957 , 文章类型： Review，,卷期：2008年27-55] The Epithelial Polarity Program (EPP) adapts and integrates three ancient cellular machineries to construct an epithelial cell. The polarized trafficking machinery adapts the cytoskeleton and ancestral secretory and endo... Transcriptional regulation of cell polarity in EMT and cancer [作者：Moreno-Bueno, G; Portillo, F; Cano, A,期刊：Oncogene, 页码：6958-6969 , 文章类型： Review，,卷期：2008年27-55] The epithelial-to-mesenchymal transition ( EMT) is a crucial process in tumour progression providing tumour cells with the ability to escape from the primary tumour, to migrate to distant regions and to invade tissues. E... Polarity proteins in migration and invasion [作者：Etienne-Manneville, S,期刊：Oncogene, 页码：6970-6980 , 文章类型： Review，,卷期：2008年27-55] Cancer is the result of the deregulation of cell proliferation and cell migration. In advanced tumors, cells invade the surrounding tissue and eventually form metastases. This is particularly evident in carcinomas in whi... Biomechanical regulation of cell orientation and fate [作者：Lopez, JI; Mouw, JK; Weaver, VM,期刊：Oncogene, 页码：6981-6993 , 文章类型： Review，,卷期：2008年27-55] Biomechanical regulation of tumor phenotypes have been noted for several decades, yet the function of mechanics in the co-evolution of the tumor epithelium and altered cancer extracellular matrix has not been appreciated... Drosophila asymmetric division, polarity and cancer [作者：Januschke, J; Gonzalez, C,期刊：Oncogene, 页码：6994-7002 , 文章类型： Review，,卷期：2008年27-55] A limited number of adult stem cells (SCs) maintain the homoestasis of different tissues through the lifetime of the individual by generating differentiating daughters and renewing themselves. Errors in the SC division r... Upsides and downsides to polarity and asymmetric cell division in leukemia [作者：Hawkins, ED; Russell, SM,期刊：Oncogene, 页码：7003-7017 , 文章类型： Review，,卷期：2008年27-55] The notion that polarity regulators can act as tumor suppressors in epithelial cells is now well accepted. The function of these proteins in lymphocytes is less well explored, and their possible function as suppressors o... Human papillomaviruses, cervical cancer and cell polarity [作者：Thomas, M; Narayan, N; Pim, D; Tomaic, V; Massimi, P; Nagasaka, K; Kranjec, C; Gammoh, N; Banks, L,期刊：Oncogene, 页码：7018-7030 , 文章类型： Review，,卷期：2008年27-55] Human papillomaviruses (HPVs) are the causative agents of a number of human cancers, of which cervical cancer is the most important. This occurs following persistent infection with a limited number of viral subtypes and ...