- Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55
[作者：Wang, H; Song, K; Krebs, TL; Yang, J; Danielpour, D,期刊：Oncogene, 页码：6791-6805 , 文章类型： Article，,卷期：2008年27-54]
- We recently reported that hydrogen peroxide-inducible clone-5 (Hic-5, also named androgen receptor-associated protein 55) can bind to the transforming growth factor-beta (TGF-beta)-signaling regulator Smad3, thereby inhi...
- In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation
[作者：Taghavi, P; Verhoeven, E; Jacobs, JJL; Lambooij, JP; Stortelers, C; Tanger, E; Moolenaar, WH; van Lohuizen, M,期刊：Oncogene, 页码：6806-6816 , 文章类型： Article，,卷期：2008年27-54]
- c-Myc drives uncontrolled cell proliferation in various human cancers. However, in mouse embryo fibroblasts (MEFs), c-Myc also induces apoptosis by activating the p19Arf tumor suppressor pathway. Tbx2, a transcriptional ...
- Epigenetic regulation of telomeres in human cancer
[作者：Vera, E; Canela, A; Fraga, MF; Esteller, M; Blasco, MA,期刊：Oncogene, 页码：6817-6833 , 文章类型： Article，,卷期：2008年27-54]
- Hypomethylation of repeated elements in the genome is a common feature of human cancer, however, the direct consequences of this epigenetic defect for cancer biology are still largely unknown. Telomeres are specialized c...
- Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling
[作者：Pen, A; Moreno, MJ; Durocher, Y; Deb-Rinker, P; Stanimirovic, DB,期刊：Oncogene, 页码：6834-6844 , 文章类型： Article，,卷期：2008年27-54]
- Insulin-like growth factor-binding protein 7 (IGFBP7) is a selective biomarker of glioblastoma (GBM) vessels, stronglyexpressed in tumor endothelial cells and vascular basement membrane. IGFBP7 gene regulation and its po...
- The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11
[作者：Chen, C; Zhou, Z; Liu, R; Li, Y; Azmi, PB; Seth, AK,期刊：Oncogene, 页码：6845-6855 , 文章类型： Article，,卷期：2008年27-54]
- The WW domain containing E3 ubiquitin protein ligase 1 (WWP1) is a homologous to the E6-associated protein C terminus-type E3 ligase frequently overexpressed in human prostate and breast cancers due to gene amplification...
- The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells
[作者：McKinnon, CM; Lygoe, KA; Skelton, L; Mitter, R; Mellor, H,期刊：Oncogene, 页码：6856-6865 , 文章类型： Article，,卷期：2008年27-54]
- The Rho family of small GTPases control cell migration, cell invasion and cell cycle. Many of these processes are perturbed in cancer and several family members show altered expression in a number of tumor types. RhoBTB2...
- p53 controls hPar1 function and expression
[作者：Salah, Z; Haupt, S; Maoz, M; Baraz, L; Rotter, V; Peretz, T; Haupt, Y; Bar-Shavit, R,期刊：Oncogene, 页码：6866-6874 , 文章类型： Article，,卷期：2008年27-54]
- Human protease-activated receptor 1(hPar1) is a bonafide receptor of the hemostatic protease thrombin, and has a central function in tumor progression. Inactivation of the tumor suppressor gene p53 is one of the most com...
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