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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival [作者：Wang, Y; Mikhailova, M; Bose, S; Pan, CX; White, RD; Ghosh, PM,期刊：Oncogene, 页码：7106-7117 , 文章类型： Article，,卷期：2008年27-56] The mTOR (mammalian target of rapamycin) inhibit or rapamycin caused growth arrest in both androgen-dependent and androgen-independent prostate cancer cells; however, long-term treatment induced resistance to the drug. T... Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis [作者：Li, X; Placencio, V; Iturregui, JM; Uwamariya, C; Sharif-Afshar, AR; Koyama, T; Hayward, SW; Bhowmick, NA,期刊：Oncogene, 页码：7118-7130 , 文章类型： Article，,卷期：2008年27-56] Transforming growth factor (TGF)-beta is an important paracrine factor in tumorigenesis. Ligand binding of the type I and II TGF-beta receptors initiate downstream signaling. The role of stromal TGF-beta signaling in pro... CEACAM1, a SOX9 direct transcriptional target identified in the colon epithelium [作者：Zalzali, H; Naudin, C; Bastide, P; Quittau-Prevostel, C; Yaghi, C; Poulat, F; Jay, P; Blache, P,期刊：Oncogene, 页码：7131-7138 , 文章类型： Article，,卷期：2008年27-56] A deletion of the transcription factor SOX9 gene in the mice intestine affects the morphology of the colon epithelium and leads to hyperplasia. Nevertheless, direct transcriptional targets of SOX9 in this tissue are stil... An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259 [作者：Pene-Dumitrescu, T; Peterson, LF; Donato, NJ; Smithgall, TE,期刊：Oncogene, 页码：7055-7069 , 文章类型： Article，,卷期：2008年27-56] Chronic myelogenous leukemia (CML) is driven by Bcr-Abl, a constitutively active protein-tyrosine kinase that stimulates proliferation and survival of myeloid progenitors. Global inhibition of myeloid Src family kinase (... Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence [作者：Leikam, C; Hufnagel, A; Schartl, M; Meierjohann, S,期刊：Oncogene, 页码：7070-7082 , 文章类型： Article，,卷期：2008年27-56] Contrary to malignant melanoma, nevi are a benign form of melanocytic hyperproliferation. They are frequently observed as precursor lesions of melanoma, but they also feature biochemical markers of senescence. In particu... Cyclin-dependent kinase 4/6 activity is a critical determinant of pre-replication complex assembly [作者：Braden, WA; McClendon, AK; Knudsen, ES,期刊：Oncogene, 页码：7083-7093 , 文章类型： Article，,卷期：2008年27-56] Cyclin-dependent kinases (CDKs) are important in regulating cell cycle transitions, particularly in coordinating DNA replication. Although the role of CDK2 activity on the replication apparatus has been extensively studi... Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer [作者：Wolf, I; Levanon-Cohen, S; Bose, S; Ligumsky, H; Sredni, B; Kanety, H; Kuro-o, M; Karlan, B; Kaufman, B; Koeffler, HP; Rubinek, T,期刊：Oncogene, 页码：7094-7105 , 文章类型： Article，,卷期：2008年27-56] Klotho is an anti-aging gene, which has been shown to inhibit the insulin and insulin-like growth factor 1 (IGF-1) pathways in mice hepatocytes and myocytes. As IGF-1 and insulin regulate proliferation, survival and meta...