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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Disulfide-Depleted Selenoconopeptides: Simplified Oxidative Folding of Cysteine-Rich Peptides [作者：HAN TIFFANY S; ZHANG MINMIN; GOWD KONKALLU HANUMAE; WALEWSKA ALEKSANDRA; YOSHIKAMI DOJU; OLIVERA BALDOMERO M; BULAJ GRZEGORZ,期刊：ACS Medicinal Chemistry Letters, 页码：140-144 , 文章类型： Article，,卷期：2010年1-4] Despite the therapeutic promise of disulfide-rich, peptidic natural products, their discovery and structure/function studies have been hampered by inefficient oxidative folding methods for their synthesis. Here we report... Identification of Novel Urease Inhibitors by High-Throughput Virtual and in Vitro Screening [作者：ABID OBAIDURRAHMAN; BABAR TARIQ MAHMOOD; ALI FARUKH IFTAKHAR; AHMED SHAHZAD; WADOOD ABDUL; RAMA NASIM HASAN; UDDIN REAZ; ZAHEERULHAQ; KHAN AJMAL; CHOUDHARY M IQBAL,期刊：ACS Medicinal Chemistry Letters, 页码：145-149 , 文章类型： Article，,卷期：2010年1-4] Ureases are important in both agriculture and human health. Bacterial ureases are directly involved in many farm-field problems and pathological conditions. Here, we report a structure-based virtual screening of an in-ho... NH-1,2,3-Triazole Inhibitors of the VIM-2 Metallo-beta-Lactamase [作者：WEIDE TIMO; SALDANHA S ADRIAN; MINOND DMITRIY; SPICER TIMOTHY P; FOTSING JOSEPH R; SPAARGAREN MICHAEL; FRERE JEANMARIE; BEBRONE CARINE; SHARPLESS K BARRY; HODDER PETER S; FOKIN VALERY V,期刊：ACS Medicinal Chemistry Letters, 页码：150-154 , 文章类型： Article，,卷期：2010年1-4] Metallo-beta-lactamases (MBLs) are an emerging cause of bacterial resistance to antibiotic treatment. The VIM-2 beta-lactamase is the most commonly encountered MBLs in clinical isolates worldwide. Described here are pote... Impact of Absolute Stereochemistry on the Antiangiogenic and Antifungal Activities of Itraconazole [作者：SHI WEI; NACEV BENJAMIN A; BHAT SHRIDHAR; LIU JUN O,期刊：ACS Medicinal Chemistry Letters, 页码：155-159 , 文章类型： Article，,卷期：2010年1-4] Itraconazole is used clinically as an antifungal agent and has recently been shown to possess antiangiogenic acitivity. Itraconazole has three chiral centers that give rise to eight stereoisomers. The complete role of st... Hydration Site Thermodynamics Explain SARs for Triazolylpurines Analogues Binding to the A2A Receptor [作者：HIGGS CHRISTOPHER; BEUMING THIJS; SHERMAN WOODY,期刊：ACS Medicinal Chemistry Letters, 页码：160-164 , 文章类型： Article，,卷期：2010年1-4] A series of triazolylpurine analogues show interesting and unintuitive structure activity relationships against the A2A adenosine receptor. As the 2-substituted aliphatic group is initially increased to methyl and isopro... Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents [作者：DING DAZHONG; ZHAO YAXUE; MENG QINGQING; XIE DONGSHENG; NARE BAKELA; CHEN DAITAO; BACCHI CYRUS J; YARLETT NIGEL; ZHANG YONGKANG; HERNANDEZ VINCENT; XIA YI; FREUND YVONNE; ABDULLA MAHA; ANG KEANHOOI; RATNAM JOSELINE; MCKERROW JAMES H; JACOBS ROBERT T; ZHOU HUCHEN; PLATTNER JACOB J,期刊：ACS Medicinal Chemistry Letters, 页码：165-169 , 文章类型： Article，,卷期：2010年1-4] We report the discovery of benzoxaborole antitrypanosomal agents and their structure activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed ... The Discovery of Setileuton, a Potent and Selective 5-Lipoxygenase Inhibitor [作者：DUCHARME YVES; BLOUIN MARC; BRIDEAU CHRISTINE; CHATEAUNEUF ANNE; GAREAU YVES; GRIMM ERICH L; JUTEAU HELENE; LALIBERTE SEBASTIEN; MACKAY BRUCE; MASSE FREDERIC; OUELLET MARC; SALEM MYRIAM; STYHLER ANGELA; FRIESEN RICHARD W,期刊：ACS Medicinal Chemistry Letters, 页码：170-174 , 文章类型： Article，,卷期：2010年1-4] The discovery of novel and selective inhibitors of human 5-lipoxygenase (5-LO) is described. These compounds are potent, orally bioavailable, and active at inhibiting leukotriene biosynthesis in vivo in a dog PK/PD model... Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats [作者：YIN YAN; CAMERON MICHAEL D; LIN LI; KHAN SUSAN; SCHROETER THOMAS; GRANT WAYNE; POCAS JENNIFER; CHEN YEN TING; SCHUERER STEPHAN; PACHORI ALOK; LOGRASSO PHILIP; FENG YANGBO,期刊：ACS Medicinal Chemistry Letters, 页码：175-179 , 文章类型： Article，,卷期：2010年1-4] A series of urea-based Rho kinase (ROCK) inhibitors were designed and evaluated. The discovered compounds had excellent enzyme and cellular potency, high kinase selectivity, high aqueous solubility, good porcine corneal ... Eradication of Pathogenic Bacteria by Remote Delivery of NO via Light Triggering of Nitrosyl-Containing Materials [作者：HALPENNY GENEVIEVE M; GANDHI KAVITA R; MASCHARAK PRADIP K,期刊：ACS Medicinal Chemistry Letters, 页码：180-183 , 文章类型： Article，,卷期：2010年1-4] Although nitric oxide (NO) delivery systems have been fabricated with sol gel-based materials, remote control of such systems with light has not been achieved. In this work, a fiber optic-based NO delivery system is desc... The Discovery of Pyridone and Pyridazone Heterocycles as gamma-Secretase Modulators [作者：HUANG XIANHAI; ASLANIAN ROBERT; ZHOU WEI; ZHU XIAOHONG; QIN JUN; GREENLEE WILLIAM; ZHU ZHAONING; ZHANG LILI; HYDE LYNN; CHU INHOU; COHENWILLIAMS MARY; PALANI ANANDAN,期刊：ACS Medicinal Chemistry Letters, 页码：184-187 , 文章类型： Article，,卷期：2010年1-4] A series of novel pyridazone and pyridone compounds as gamma-secretase modulators were discovered. Starting from the initial lead, structure activity relationship studies were carried out in which an internal hydrogen bo...