- Evolutionary inspirations for drug discovery
[作者:Zhang, HY; Chen, LL; Li, XJ; Zhang, JA,期刊:Trends in Pharmacological Sciences, 页码:443-448 , 文章类型: Review,,卷期:2010年31-10]
- Conceptual innovations are needed to address the challenge of 'more investments, fewer drugs' in the pharmaceutical industry. Since the publication of The Origin of Species by Charles Darwin 150 years ago, evolution has ...
- Drug-lipid interaction evaluation: why a 19th century solution?
[作者:Ribeiro, MMB; Melo, MN; Serrano, ID; Santos, NC; Castanho, MARB,期刊:Trends in Pharmacological Sciences, 页码:449-454 , 文章类型: Review,,卷期:2010年31-10]
- The affinity of a drug candidate for a biological membrane (its lipophilicity) is closely related to the pharmacologically crucial events of absorption, biodistribution, metabolization and excretion. The evolution of kno...
- The pleasures of play: pharmacological insights into social reward mechanisms
[作者:Trezza, V; Baarendse, PJJ; Vanderschuren, LJMJ,期刊:Trends in Pharmacological Sciences, 页码:463-469 , 文章类型: Review,,卷期:2010年31-10]
- Like human children, most young mammals devote a significant amount of time and energy playing together, and social play is fun. Although social play is very pleasurable, it is more than just a frivolous activity: it is ...
- Regulation of signal transduction by calcitonin gene-related peptide receptors
[作者:Walker, CS; Conner, AC; Poyner, DR; Hay, DL,期刊:Trends in Pharmacological Sciences, 页码:476-483 , 文章类型: Review,,卷期:2010年31-10]
- Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine, activating its cognate receptor to initiate intracellular signalling. This atypical receptor comprises a distinct assembly, made up of a G protein-...
- Preclinical models of antipsychotic drug-induced metabolic side effects
[作者:Boyda, HN; Tse, L; Procyshyn, RM; Honer, WG; Barr, AM,期刊:Trends in Pharmacological Sciences, 页码:484-496 , 文章类型: Review,,卷期:2010年31-10]
- Antipsychotic drugs (APDs), and the 'atypical' APDs in particular, are commonly associated with metabolic side effects in humans. These include glucose dysregulation, insulin resistance, hyperlipidemia, weight gain and h...
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