The energy demands of the brain are exceptionally high compared with any other organ of the body. A complex control system maintains brain energy homeostasis, mobilizing appropriate energy substrates to satisfy the energ...
gamma-Secretase is a key enzyme in the pathophysiology of Alzheimer's disease (AD) and is responsible for the production of potentially toxic amyloid-beta (A beta) 42 peptides. gamma-Secretase modulators (GSMs) are small...
Small-animal positron emission tomography (PET) is a preclinical imaging method that uses pharmacologically or biochemically active compounds labelled with short-lived positron-emitting radionuclides. This non-invasive n...
Secondary active transporters catalyze the concentrative transport of substrates across lipid membranes by harnessing the energy of electrochemical ion gradients. These transporters bind their ligands on one side of the ...
Peripheral mechanisms of endogenous pain control are significant. In peripheral inflamed tissue, an interaction between immune-cell-derived opioids and opioid receptors localized on sensory nerve terminals results in pot...
Major indications for use of peptide-based therapeutics include endocrine functions (especially diabetes mellitus and obesity), infectious diseases, and cancer. Whereas some peptide pharmaceuticals are drugs, acting as a...