- Dysregulation of Ezrin Phosphorylation Prevents Metastasis and Alters Cellular Metabolism in Osteosarcoma
[作者:Ren, L; Hong, SH; Chen, QR; Briggs, J; Cassavaugh, J; Srinivasan, S; Lizardo, MM; Mendoza, A; Xia, AY; Avadhani, N; Khan, J; Khanna, C,期刊:Cancer research, 页码:1001-1012 , 文章类型: Article,,卷期:2012年72-4]
- Ezrin links the plasma membrane to the actin cytoskeleton where it plays a pivotal role in the metastatic progression of several human cancers; however, the precise mechanistic basis for its role remains unknown. Here, w...
- Hedgehog and Notch Signaling Regulate Self-Renewal of Undifferentiated Pleomorphic Sarcomas
[作者:Wang, CYY; Wei, QX; Han, I; Sato, S; Ghanbari-Azarnier, R; Whetstone, H; Poon, R; Hu, JY; Zheng, FF; Zhang, P; Wang, WS; Wunder, JS; Alman, BA,期刊:Cancer research, 页码:1013-1022 , 文章类型: Article,,卷期:2012年72-4]
- Like many solid tumors, sarcomas are heterogeneous and include a small fraction of the so-called side population (SP) cells with stem-like tumor-initiating potential. Here, we report that SP cells from a soft tissue tumo...
- Mammary Gland Selective Excision of c-Jun Identifies Its Role in mRNA Splicing
[作者:Katiyar, S; Jiao, XM; Addya, S; Ertel, A; Covarrubias, Y; Rose, V; Casimiro, MC; Zhou, J; Lisanti, MP; Nasim, T; Fortina, P; Pestell, RG,期刊:Cancer research, 页码:1023-1034 , 文章类型: Article,,卷期:2012年72-4]
- The c-jun gene regulates cellular proliferation and apoptosis via direct regulation of cellular gene expression. Alternative splicing of pre-mRNA increases the diversity of protein functions, and alternate splicing event...
- Regulation of Cancer Progression by beta-Endorphin Neuron
[作者:Sarkar, DK; Murugan, S; Zhang, CQ; Boyadjieva, N,期刊:Cancer research, 页码:836-840 , 文章类型: Review,,卷期:2012年72-4]
- It is becoming increasingly clear that stressful life events can affect cancer growth and metastasis by modulating nervous, endocrine, and immune systems. The purpose of this review is to briefly describe the process by ...
- Twenty-Third Annual Pezcoller Symposium: Engineering Influences in Cancer Research
[作者:Friedl, P; Hubbell, J; Livingston, D; Mihich, E,期刊:Cancer research, 页码:841-844 , 文章类型: Editorial Material,,卷期:2012年72-4]
- The cross-disciplinary focus of the meeting highlighted recent progress in physical and genetic analysis and engineering of cancer disease models. As the central theme, mechanical forces affecting cell signaling, growth,...
- N-Myc Regulates Expression of the Detoxifying Enzyme Glutathione Transferase GSTP1, a Marker of Poor Outcome in Neuroblastoma
[作者:Fletcher, JI; Gherardi, S; Murray, J; Burkhart, CA; Russell, A; Valli, E; Smith, J; Oberthuer, A; Ashton, LJ; London, WB; Marshall, GM; Norris, MD; Perini, G; Haber, M,期刊:Cancer research, 页码:845-853 , 文章类型: Article,,卷期:2012年72-4]
- Amplification of the transcription factor MYCN is associated with poor outcome and a multidrug-resistant phenotype in neuroblastoma. N-Myc regulates the expression of several ATP-binding cassette (ABC) transporter genes,...
- Monocytic CCR2(+) Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment
[作者:Lesokhin, AM; Hohl, TM; Kitano, S; Cortez, C; Hirschhorn-Cymerman, D; Avogadri, F; Rizzuto, GA; Lazarus, JJ; Pamer, EG; Houghton, AN; Merghoub, T; Wolchok, JD,期刊:Cancer research, 页码:876-886 , 文章类型: Article,,卷期:2012年72-4]
- Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells that accumulate during tumor formation, facilitate immune escape, and enable tumor progression. MDSCs are important contributors to the deve...
- CD8(+) T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1
[作者:Fourcade, J; Sun, ZJ; Pagliano, O; Guillaume, P; Luescher, IF; Sander, C; Kirkwood, JM; Olive, D; Kuchroo, V; Zarour, HM,期刊:Cancer research, 页码:887-896 , 文章类型: Article,,卷期:2012年72-4]
- Cytotoxic T cells that are present in tumors and capable of recognizing tumor epitopes are nevertheless generally impotent in eliciting tumor rejection. Thus, identifying the immune escape mechanisms responsible for indu...
- Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment
[作者:Heller, E; Hurchla, MA; Xiang, JY; Su, XM; Chen, S; Schneider, J; Joeng, KS; Vidal, M; Goldberg, L; Deng, HJ; Hornick, MC; Prior, JL; Piwnica-Worms, D; Long, FX; Cagan, R; Weilbaecher, KN,期刊:Cancer research, 页码:897-907 , 文章类型: Article,,卷期:2012年72-4]
- Hedgehog (Hh) signaling is implicated in bone development and cellular transformation. Here we show that inhibition of Hh pathway activity inhibits tumor growth through effects on the microenvironment. Pharmacologic inhi...
- Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
[作者:Woo, SR; Turnis, ME; Goldberg, MV; Bankoti, J; Selby, M; Nirschl, CJ; Bettini, ML; Gravano, DM; Vogel, P; Liu, CL; Tangsombatvisit, S; Grosso, JF; Netto, G; Smeltzer, MP; Chaux, A; Utz, PJ; Workman, CJ; Pardoll, DM; Korman, AJ; Drake, CG; Vignali, DAA,期刊:Cancer research, 页码:917-927 , 文章类型: Article,,卷期:2012年72-4]
- Inhibitory receptors on immune cells are pivotal regulators of immune escape in cancer. Among these inhibitory receptors, CTLA-4 (targeted clinically by ipilimumab) serves as a dominant off-switch while other receptors s...
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