- Polyphenols from Red Wine Modulate Immune Responsiveness: Biological and Clinical Significance
[作者:Magrone, T; Candore, G; Caruso, C; Jirillo, E; Covelli, V,期刊:Current Pharmaceutical Design, 页码:2733-2748 , 文章类型: Review,,卷期:2008年14-26]
- Many studies have been conducted on the effects of red wine polyphenols on certain diseases, primarily, coronary heart disease (CHD) and, in this respect, evidence has been demonstrated that intake of red wine is associa...
- Elicitation of Immune Responsiveness Against Antigenic Challenge in Age- Related Diseases: Effects of Red Wine Polyphenols
[作者:Magrone, T; Tafaro, A; Jirillo, F; Amati, L; Jirillo, E; Covelli, V,期刊:Current Pharmaceutical Design, 页码:2749-2757 , 文章类型: Review,,卷期:2008年14-26]
- Polyphenols contained in red wine possess a broad array of properties which seem to be beneficial to human and animal health. We have investigated the ability of red wine polyphenols to promote the in vitro release of bo...
- A Scientific Approach to Anti-Ageing Therapies: State of the Art
[作者:Jirillo, E; Candore, G; Magrone, T; Caruso, C,期刊:Current Pharmaceutical Design, 页码:2637-2642 , 文章类型: Review,,卷期:2008年14-26]
- A lasting dream of human beings is to reverse or at least postpone ageing. During the last years, an increasing number of scientific meetings, articles, and books have been devoted to anti-ageing therapies. This subject,...
- The Use of the Inhibitory Receptors for Modulating the Immune Responses
[作者:Henson, SM; Macaulay, R; Kiani-Alikhan, S; Akbar, AN,期刊:Current Pharmaceutical Design, 页码:2643-2650 , 文章类型: Review,,卷期:2008年14-26]
- Inhibitory receptors of the CD28 family, CTLA-4 and PD-1 deliver negative signals that regulate the balance between T cell activation, tolerance, and immunopathology. Manipulation of these pathways has been utilized by p...
- Post-Transcriptional Regulation of HSP70 Expression Following Oxidative Stress in SH-SY5Y Cells: The Potential Involvement of the RNA-Binding Protein HuR
[作者:Amadio, M; Scapagnini, G; Laforenza, U; Intrieri, M; Romeo, L; Govoni, S; Pascale, A,期刊:Current Pharmaceutical Design, 页码:2651-2658 , 文章类型: Review,,卷期:2008年14-26]
- Brain aging is associated with a progressive imbalance between intracellular concentration of Reactive Oxygen Species (ROS) and cells ability to activate defensive genes. Heat Shock Protein 70 (HSP70) has been shown to a...
- Elevated Plasma Levels of alpha-1-Anti-Chymotrypsin in Age-Related Cognitive Decline and Alzheimer's Disease: A Potential Therapeutic Target
[作者:Porcellini, E; Davis, EJ; Chiappelli, M; Ianni, E; Di Stefano, G; Forti, P; Ravaglia, G; Licastro, F,期刊:Current Pharmaceutical Design, 页码:2659-2664 , 文章类型: Review,,卷期:2008年14-26]
- 1-antichymotrypsin ACT), is an acute phase protein and a protease inhibitor produced by the liver and brain. ACT is involved in the pathogenesis of Alzheimer's disease (AD), since elevated ACT concentration was found in ...
- Pharmacogenetics and Pharmagenomics, Trends in Normal and Pathological Aging Studies: Focus on p53
[作者:Lanni, C; Racchi, M; Uberti, D; Mazzini, G; Stanga, S; Sinforiani, E; Memo, M; Govoni, S,期刊:Current Pharmaceutical Design, 页码:2665-2671 , 文章类型: Review,,卷期:2008年14-26]
- In spite of the fact that the aging organism is the result of complex life-long gene/environment interactions, making peculiar the susceptibility to diseases and the response to drugs, pharmacogenetics studies are largel...
- Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimer's Disease
[作者:Balistreri, CR; Grimaldi, MP; Chiappelli, M; Licastro, F; Castiglia, L; Listi, F; Vasto, S; Lio, D; Caruso, C; Candore, G,期刊:Current Pharmaceutical Design, 页码:2672-2677 , 文章类型: Review,,卷期:2008年14-26]
- Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western society mainly accounts for clinical dementia. Inflammation plays a key role in AD and dissecting the genetics of inf...
- Pro-Inflammatory Gene Variants in Myocardial Infarction and Longevity: Implications for Pharmacogenomics
[作者:Listi, F; Caruso, M; Incalcaterra, E; Hoffmann, E; Caimi, G; Balistreri, CR; Vasto, S; Scafidi, V; Caruso, C; Candore, G,期刊:Current Pharmaceutical Design, 页码:2678-2685 , 文章类型: Review,,卷期:2008年14-26]
- Inflammation and genetics play an important role in the pathogenesis of coronary heart disease (CHD). However, despite the increasing appreciation of the role of genetics in CHD and myocardial infarction (MI) pathogenesi...
- Prognostic Role of Sub-Clinical Hypothyroidism in Chronic Heart Failure Outpatients
[作者:Iacoviello, M; Guida, P; Guastamacchia, E; Triggiani, V; Forleo, C; Catanzaro, R; Cicala, M; Basile, M; Sorrentino, S; Favale, S,期刊:Current Pharmaceutical Design, 页码:2686-2692 , 文章类型: Review,,卷期:2008年14-26]
- Background. It has been suggested that low thyroid hormones levels may be associated with increased mortality in patients with cardiovascular disease. Aim. To evaluate the prognostic role of thyroid function deficiency i...
- Relationship Among Fatty Liver, Adipose Tissue Distribution and Metabolic Profile in Moderately Obese Children: An Ultrasonographic Study
[作者:Chiloiro, M; Riezzo, G; Chiarappa, S; Correale, M; Guerra, V; Amati, L; Noviello, MR; Jirillo, E,期刊:Current Pharmaceutical Design, 页码:2693-2698 , 文章类型: Review,,卷期:2008年14-26]
- We examined the relationship between moderate obesity and glucose metabolism, insulin sensitivity and suspected fatty liver in children. We measured body mass index (BMI),z-score BMI, caliper skinfold thickness, waist an...
- Body Composition and-174G/C Interleukin-6 Promoter Gene Polymorphism: Association with Progression of Insulin Resistance in Normal Weight Obese Syndrome
[作者:Di Renzo, L; Bertoli, A; Bigioni, M; Del Gobbo, V; Premrov, MG; Calabrese, V; Di Daniele, N; De Lorenzo, A,期刊:Current Pharmaceutical Design, 页码:2699-2706 , 文章类型: Review,,卷期:2008年14-26]
- Insulin resistance and obesity are intimately related to a chronic low grade systemic inflammation. Interleukin-6 (IL-6) may influence the pathogenesis of obesity-related diseases. The aim of this study is to investigate...
- Role of Diet and Nutrition on the Alteration of the Quality and Quantity of Stem Cells in Human Aging and the Diseases of Aging
[作者:Trosko, JE,期刊:Current Pharmaceutical Design, 页码:2707-2718 , 文章类型: Review,,卷期:2008年14-26]
- An integrative synthesis of concepts and an explosion of experimental and epidemiological findings allow new insights as to how the interactions of genetic, environmental, dietary, cultural (social, psychological, econom...
- Zinc, Metallothioneins and Longevity: Interrelationships with Niacin and Selenium
[作者:Mocchegiani, E; Malavolta, M; Muti, E; Costarelli, L; Cipriano, C; Piacenza, F; Tesei, S; Giacconi, R; Lattanzio, F,期刊:Current Pharmaceutical Design, 页码:2719-2732 , 文章类型: Review,,卷期:2008年14-26]
- Ageing is an inevitable biological process with gradual and spontaneous biochemical and physiological changes and increased susceptibility to diseases. Some nutritional factors (zinc, niacin, selenium) may remodel these ...
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