- Norzotepine, a Major Metabolite of Zotepine, Exerts Atypical Antipsychotic-Like and Antidepressant-Like Actions through Its Potent Inhibition of Norepinephrine Reuptake
[作者:Shobo, M; Kondo, Y; Yamada, H; Mihara, T; Yamamoto, N; Katsuoka, M; Harada, K; Ni, K; Matsuoka, N,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:772-781 , 文章类型: Article,,卷期:2010年333-3]
- The antipsychotic drug zotepine [ZTP; 2-[(8-chlorodibenzo[b,f] thiepin-10-yl)oxy]-N,N-dimethylethan-1-amine] is known to have not only atypical antipsychotic effects but also antidepressive effects in schizophrenia patie...
- Glucocorticoid- Dependent Expression of O-6-Methylguanine-DNA Methyltransferase Gene Modulates Dacarbazine-Induced Hepatotoxicity in Mice
[作者:Horiguchi, M; Kim, J; Matsunaga, N; Kaji, H; Egawa, T; Makino, K; Koyanagi, S; Ohdo, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:782-787 , 文章类型: Article,,卷期:2010年333-3]
- O-6-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense against the alkylating agent-induced cytotoxic lesion O-6-alkylguanine in DNA. Although a significant circadian variation in MGMT activit...
- Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone
[作者:Kodaira, H; Kusuhara, H; Ushiki, J; Fuse, E; Sugiyama, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:788-796 , 文章类型: Article,,卷期:2010年333-3]
- breast cancer resistance protein (Bcrp)/Abcg2 was reported to limit the brain penetration of their common substrates. This study investigated this based on pharmacokinetics using Mdr1a/1b(-/-), Bcrp(-/-), and Mdr1a/1b(-/...
- Extracellular 3 ',5 '-cAMP-Adenosine Pathway Inhibits Glomerular Mesangial Cell Growth
[作者:Dubey, RK; Rosselli, M; Gillespie, DG; Mi, ZC; Jackson, EK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:808-815 , 文章类型: Article,,卷期:2010年333-3]
- Abnormal growth of glomerular mesangial cells (GMCs) contributes to the pathophysiology of many types of nephropathy. Because adenosine is an autocrine/paracrine factor that potentially could regulate GMC proliferation a...
- A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor alpha Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation
[作者:Mourey, RJ; Burnette, BL; Brustkern, SJ; Daniels, JS; Hirsch, JL; Hood, WF; Meyers, MJ; Mnich, SJ; Pierce, BS; Saabye, MJ; Schindler, JF; South, SA; Webb, EG; Zhang, JA; Anderson, DR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:797-807 , 文章类型: Article,,卷期:2010年333-3]
- Activation of the p38 kinase pathway in immune cells leads to the transcriptional and translational regulation of proinflammatory cytokines. Mitogen-activated protein kinase-activated protein kinase 2 (MK2), a direct dow...
- Inhibition of I kappa B Kinase-beta Protects Dopamine Neurons Against Lipopolysaccharide-Induced Neurotoxicity
[作者:Zhang, F; Qian, L; Flood, PM; Shi, JS; Hong, JS; Gao, HM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:822-833 , 文章类型: Article,,卷期:2010年333-3]
- Parkinson's disease (PD) is a progressive neurological disorder characterized by a selective loss of dopamine (DA) neurons in the substantia nigra (SN). Although current therapy can control symptoms of this disorder, the...
- Novel Anticytomegalovirus Activity of Immunosuppressant Mizoribine and Its Synergism with Ganciclovir
[作者:Kuramoto, T; Daikoku, T; Yoshida, Y; Takemoto, M; Oshima, K; Eizuru, Y; Kanda, Y; Miyawaki, T; Shiraki, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:816-821 , 文章类型: Article,,卷期:2010年333-3]
- Cytomegalovirus (CMV) infection is a prominent infection in transplant recipients. The immunosuppressive drug mizoribine was shown to have anti-CMV activity in vitro and was reported to have an anti-CMV effect in renal t...
- A Selective Peroxisome Proliferator-Activated Receptor alpha Agonist, CP-900691, Improves Plasma Lipids, Lipoproteins, and Glycemic Control in Diabetic Monkeys
[作者:Wagner, JD; Shadoan, MK; Zhang, L; Ward, GM; Royer, LJ; Kavanagh, K; Francone, OL; Auerbach, BJ; Harwood, HJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:844-853 , 文章类型: Article,,卷期:2010年333-3]
- Peroxisome proliferator-activated receptors (PPARs) are involved in the regulation of lipid and glucose metabolism. PPAR gamma agonists improve insulin sensitivity and hyperglycemia and are effective in treating type 2 d...
- Reduction of L-DOPA-Induced Dyskinesia by the Selective Metabotropic Glutamate Receptor 5 Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Macaque Model of Parkinson's Disease
[作者:Johnston, TH; Fox, SH; McIldowie, MJ; Piggott, MJ; Brotchie, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:865-873 , 文章类型: Article,,卷期:2010年333-3]
- Long-term motor complications of dopamine replacement, such as L-DOPA-induced dyskinesia (LID) and reduced quality of L-DOPA action, remain obstacles in the treatment of Parkinson's disease. Dysfunctional glutamatergic n...
- Characterization of the Transport, Metabolism, and Pharmacokinetics of the Dopamine D3 Receptor-Selective Fluorenyl- and 2-Pyridylphenyl Amides Developed for Treatment of Psychostimulant Abuse
[作者:Mason, CW; Hassan, HE; Kim, KP; Cao, JJ; Eddington, ND; Newman, AH; Voulalas, PJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:854-864 , 文章类型: Article,,卷期:2010年333-3]
- The recent discovery of novel high-affinity and selective dopamine D3 receptor (DA D3R) antagonists and partial agonists has provided tools with which to further elucidate the role DA D3R plays in substance abuse. The pr...
- Nitro-Oleic Acid Inhibits Firing and Activates TRPV1-and TRPA1-Mediated Inward Currents in Dorsal Root Ganglion Neurons from Adult Male Rats
[作者:Sculptoreanu, A; Kullmann, FA; Artim, DE; Bazley, FA; Schopfer, F; Woodcock, S; Freeman, BA; de Groat, WC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:883-895 , 文章类型: Article,,卷期:2010年333-3]
- Nitro-oleic acid (OA-NO2), an electrophilic fatty acid by-product of nitric oxide and nitrite reactions, is present in normal and inflamed mammalian tissues at up to micromolar concentrations and exhibits anti-inflammato...
- The Novel Multifunctional, Iron-Chelating Drugs M30 and HLA20 Protect Pancreatic beta-Cell Lines from Oxidative Stress Damage
[作者:Mechlovich, D; Amit, T; Mandel, SA; Bar-Am, O; Bloch, K; Vardi, P; Youdim, MBH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:874-882 , 文章类型: Article,,卷期:2010年333-3]
- Increasing evidence suggests that oxidative stress (OS)induced pancreatic beta-cell impairments is involved in diabetes and diabetic complications. Our group has recently synthesized two multifunctional nontoxic, lipophi...
- Cisplatin and Oxaliplatin Inhibit Gap Junctional Communication by Direct Action and by Reduction of Connexin Expression, Thereby Counteracting Cytotoxic Efficacy
[作者:Wang, Q; You, TH; Yuan, DD; Han, X; Hong, XT; He, B; Wang, LZ; Tong, XH; Tao, LA; Harris, AL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:903-911 , 文章类型: Article,,卷期:2010年333-3]
- Cisplatin [cis-diamminedichloroplatinum(II)]/oxaliplatin [1,2-diamminocyclohexane(trans-1)oxolatoplatinum(II)] toxicity is enhanced by functional gap junctions between treated cells, implying that inhibition of gap junct...
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