- Structural Requirements for Inverse Agonism and Neutral Antagonism of Indole-, Benzimidazole-, and Thienopyrrole-Derived Histamine H-4 Receptor Ligands
[作者:Schneider, EH; Strasser, A; Thurmond, RL; Seifert, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:513-521 , 文章类型: Article,,卷期:2010年334-2]
- The human histamine H 4 receptor (hH(4)R), coexpressed with G alpha(i2) and G beta(1)gamma(2) in Sf9 insect cells, is highly constitutively active, and thioperamide [THIO; N-cyclohexyl-4-(imidazol-4yl)-1-piperidinecarbot...
- Orexins Depolarize Rostral Ventrolateral Medulla Neurons and Increase Arterial Pressure and Heart Rate in Rats Mainly via Orexin 2 Receptors
[作者:Huang, SC; Dai, YWE; Lee, YH; Chiou, LC; Hwang, LL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:522-529 , 文章类型: Article,,卷期:2010年334-2]
- An injection of orexin A or B into the cisterna magna or the rostral ventrolateral medulla (RVLM), where bulbospinal vasomotor neurons are located, elevated arterial pressure (AP) and heart rate (HR). We examined how ore...
- Prevention of HIV Protease Inhibitor-Induced Dysregulation of Hepatic Lipid Metabolism by Raltegravir via Endoplasmic Reticulum Stress Signaling Pathways
[作者:Cao, RS; Hu, YQ; Wang, Y; Gurley, EC; Studer, EJ; Wang, XA; Hylemon, PB; Pandak, WM; Sanyal, AJ; Zhang, LY; Zhou, HP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:530-539 , 文章类型: Article,,卷期:2010年334-2]
- Hyperlipidemia associated with the HIV protease inhibitor (PI), the major component of highly active antiretroviral treatment (HAART) for HIV infection, has stimulated interest in developing new agents that minimize thes...
- Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys
[作者:Achat-Mendes, C; Grundt, P; Cao, JJ; Platt, DM; Newman, AH; Spealman, RD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:556-565 , 文章类型: Article,,卷期:2010年334-2]
- Dopamine (DA) D3 and D2 receptor mechanisms are implicated in cocaine's abuse-related behavioral effects, but the relative contribution of the two receptor subtypes is only partially characterized. This study investigate...
- Analgesic Effects of a Substituted N-Triazole Oxindole (TROX-1), a State-Dependent, Voltage-Gated Calcium Channel 2 Blocker
[作者:Abbadie, C; McManus, OB; Sun, SY; Bugianesi, RM; Dai, G; Haedo, RJ; Herrington, JB; Kaczorowski, GJ; Smith, MM; Swensen, AM; Warren, VA; Williams, B; Arneric, SP; Eduljee, C; Snutch, TP; Tringham, EW; Jochnowitz, N; Liang, A; MacIntyre, DE; McGowan, E; Mistry, S; White, VV; Hoyt, SB; London, C; Lyons, KA; Bunting, PB; Volksdorf, S; Duffy, JL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:545-555 , 文章类型: Article,,卷期:2010年334-2]
- Voltage-gated calcium channel (Ca-v)2.2 (N-type calcium channels) are key components in nociceptive transmission pathways. Ziconotide, a state-independent peptide inhibitor of Ca(v)2.2 channels, is efficacious in treatin...
- A Claudin-Targeting Molecule as an Inhibitor of Tumor Metastasis
[作者:Saeki, R; Kondoh, M; Kakutani, H; Matsuhisa, K; Takahashi, A; Suzuki, H; Kakamu, Y; Watari, A; Yagi, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:576-582 , 文章类型: Article,,卷期:2010年334-2]
- metastasis of epithelium-derived tumors is the major cause of death from malignant tumors. Overexpression of claudin is observed frequently in malignant tumors. However, claudin-targeting antimetastasis therapy has never...
- Axon Reflexes Evoked by Transient Receptor Potential Vanilloid 1 Activation Are Mediated by Tetrodotoxin-Resistant Voltage-Gated Na+ Channels in Intestinal Afferent Nerves
[作者:Miranda-Morales, M; Ochoa-Cortes, F; Stern, E; Lomax, AE; Vanner, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:566-575 , 文章类型: Article,,卷期:2010年334-2]
- Capsaicin-sensitive nerves mediate axon vasodilator reflexes in the intestine, but the ion channels underlying action potential (AP) propagation are poorly understood. To examine the role of voltage-gated Na+ channels un...
- Inosine Reduces Pain-Related Behavior in Mice: Involvement of Adenosine A(1) and A(2A) Receptor Subtypes and Protein Kinase C Pathways
[作者:Nascimento, FP; Figueredo, SM; Marcon, R; Martins, DF; Macedo, SJ; Lima, DAN; Almeida, RC; Ostroski, RM; Rodrigues, ALS; Santos, ARS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:590-598 , 文章类型: Article,,卷期:2010年334-2]
- Inosine, an endogenous purine, is the first metabolite of adenosine in a reaction catalyzed by adenosine deaminase. This study aimed to investigate the antinociceptive effects of inosine against several models of pain in...
- Nicotinic Acid Decreases Apolipoprotein B100-Containing Lipoprotein Levels by Reducing Hepatic Very Low Density Lipoprotein Secretion through a Possible Diacylglycerol Acyltransferase 2 Inhibition in Obese Dogs
[作者:Le Bloc'h, J; Leray, V; Chetiveaux, M; Freuchet, B; Magot, T; Krempf, M; Nguyen, P; Ouguerram, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:583-589 , 文章类型: Article,,卷期:2010年334-2]
- Apolipoprotein B100 (apoB100) is an essential component of very low density lipoprotein (VLDL) and low-density lipoprotein (LDL), both independent markers of cardiovascular risk. Nicotinic acid (NA) is an efficacious dru...
- In Vitro-In Vivo Extrapolation Predicts Drug-Drug Interactions Arising from Inhibition of Codeine Glucuronidation by Dextropropoxyphene, Fluconazole, Ketoconazole, and Methadone in Humans
[作者:Raungrut, P; Uchaipichat, V; Elliot, DJ; Janchawee, B; Somogyi, AA; Miners, JO,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:609-618 , 文章类型: Article,,卷期:2010年334-2]
- Because codeine (COD) is eliminated primarily via glucuronidation, factors that alter COD glucuronide formation potentially affect the proportion of the dose converted to the pharmacologically active metabolite morphine....
- Pharmacokinetic-Pharmacodynamic Analysis of the Static Allodynia Response to Pregabalin and Sildenafil in a Rat Model of Neuropathic Pain
[作者:Bender, G; Florian, JA; Bramwell, S; Field, MJ; Tan, KKC; Marshall, S; DeJongh, J; Bies, RR; Danhof, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:599-608 , 文章类型: Article,,卷期:2010年334-2]
- The objective of this study was to develop a pharmacokinetic-pharmacodynamic (PK-PD) model of the static allodynia response to pregabalin with and without sildenafil in a chronic constriction injury model of neuropathic ...
- In Vitro Electrocardiographic and Cardiac Ion Channel Effects of (-)-Epigallocatechin-3-Gallate, the Main Catechin of Green Tea
[作者:Kang, JS; Cheng, H; Ji, JZ; Incardona, J; Rampe, D,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:619-626 , 文章类型: Article,,卷期:2010年334-2]
- Epigallocatechin-3-gallate (EGCG) is the major catechin found in green tea. EGCG is also available for consumption in the form of concentrated over-the-counter nutritional supplements. This compound is currently undergoi...
- 5A Apolipoprotein Mimetic Peptide Promotes Cholesterol Efflux and Reduces Atherosclerosis in Mice
[作者:Amar, MJA; D'Souza, W; Turner, S; Demosky, S; Sviridov, D; Stonik, J; Luchoomun, J; Voogt, J; Hellerstein, M; Sviridov, D; Remaley, AT,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:634-641 , 文章类型: Article,,卷期:2010年334-2]
- Intravenous administration of apolipoprotein (apo) A-I complexed with phospholipid has been shown to rapidly reduce plaque size in both animal models and humans. Short synthetic amphipathic peptides can mimic the antiath...
- Reduced Renal Clearance of a Zwitterionic Substrate Cephalexin in Mate1-Deficient Mice
[作者:Watanabe, S; Tsuda, M; Terada, T; Katsura, T; Inui, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:651-656 , 文章类型: Article,,卷期:2010年334-2]
- Multidrug and toxin extrusion 1 (MATE1/solute carrier 47A1) mediates the transport of not only organic cations but also zwitterions such as cephalexin. However, the contribution of MATE1 to tubular secretion of cephalexi...
- Endocrine and Neurochemical Effects of 3,4-Methylenedioxymethamphetamine and Its Stereoisomers in Rhesus Monkeys
[作者:Murnane, KS; Fantegrossi, WE; Godfrey, JR; Banks, ML; Howell, LL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:642-650 , 文章类型: Article,,卷期:2010年334-2]
- 3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative that elicits complex biological effects in humans. One plausible mechanism for this phenomenon is that racemic MDMA is composed of two stereoisomers t...
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