- Antinociceptive Effects of AS1892802, a Novel Rho Kinase Inhibitor, in Rat Models of Inflammatory and Noninflammatory Arthritis
[作者:Yoshimi, E; Kumakura, F; Hatori, C; Hamachi, E; Iwashita, A; Ishii, N; Terasawa, T; Shimizu, Y; Takeshita, N,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:955-963 , 文章类型: Article,,卷期:2010年334-3]
- Rho kinase (ROCK) is involved in various physiological functions, including cell motility, vasoconstriction, and neurite extension. Although a functional role of ROCK in nociception in the central nervous tissue has been...
- Prostaglandin E2 Inhibits Advanced Glycation End Product-Induced Adhesion Molecule Expression on Monocytes, Cytokine Production, and Lymphocyte Proliferation during Human Mixed Lymphocyte Reaction
[作者:Takahashi, HK; Zhang, JY; Mori, S; Liu, KY; Wake, H; Liu, R; Sadamori, H; Matsuda, H; Yagi, T; Yoshino, T; Nishibori, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:964-972 , 文章类型: Article,,卷期:2010年334-3]
- Posttransplant diabetes mellitus is a frequent complication among transplant recipients. Ligation of advanced glycation end products (AGEs) with their receptor on monocytes/macrophages plays a role in diabetes complicati...
- Transferrin Fusion Technology: A Novel Approach to Prolonging Biological Half-Life of Insulinotropic Peptides
[作者:Kim, BJ; Zhou, J; Martin, B; Carlson, OD; Maudsley, S; Greig, NH; Mattson, MP; Ladenheim, EE; Wustner, J; Turner, A; Sadeghi, H; Egan, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:682-692 , 文章类型: Article,,卷期:2010年334-3]
- Fusion proteins made up of glucagon-like peptide 1 (GLP-1) and exendin-4 (EX-4) fused to a nonglycosylated form of human transferrin (GLP-1-Tf or EX-4-Tf) were produced and characterized. GLP-1-Tf activated the GLP-1 rec...
- Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl) methanone (SAB378), a Peripherally Restricted Cannabinoid CB1/CB2 Receptor Agonist, Inhibits Gastrointestinal Motility but Has No Effect on Experimental Colitis in Mice
[作者:Cluny, NL; Keenan, CM; Duncan, M; Fox, A; Lutz, B; Sharkey, KA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:973-980 , 文章类型: Article,,卷期:2010年334-3]
- The endocannabinoid system is involved in the regulation of gastrointestinal (GI) motility and inflammation. Using the peripherally restricted cannabinoid (CB)(1)/CB2 receptor agonist naphthalen-1-yl-(4-pentyloxynaphthal...
- The Effects of Azole-Based Heme Oxygenase Inhibitors on Rat Cytochromes P450 2E1 and 3A1/2 and Human Cytochromes P450 3A4 and 2D6
[作者:Hum, M; McLaughlin, BE; Roman, G; Vlahakis, JZ; Szarek, WA; Nakatsu, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:981-987 , 文章类型: Article,,卷期:2010年334-3]
- Heme oxygenases (HOs) catalyze the degradation of heme to biliverdin, carbon monoxide (CO), and free iron. The two major isoforms, HO-1 (inducible) and HO-2 (constitutive), are involved in a variety of physiological func...
- Phosphoinositide 3-Kinase gamma Regulates Airway Smooth Muscle Contraction by Modulating Calcium Oscillations
[作者:Jiang, HH; Abel, PW; Toews, ML; Deng, CS; Casale, TB; Xie, Y; Tu, YP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:703-709 , 文章类型: Article,,卷期:2010年334-3]
- Phosphoinositide 3-kinase gamma (PI3K gamma) has been implicated in the pathogenesis of asthma, but its mechanism has been considered indirect, through release of inflammatory cell mediators. Because airway smooth muscle...
- Selective Inhibition of Carbonic Anhydrase IX Decreases Cell Proliferation and Induces Ceramide-Mediated Apoptosis in Human Cancer Cells
[作者:Cianchi, F; Vinci, MC; Supuran, CT; Peruzzi, B; De Giuli, P; Fasolis, G; Perigli, G; Pastorekova, S; Papucci, L; Pini, A; Masini, E; Puccetti, L,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:710-719 , 文章类型: Article,,卷期:2010年334-3]
- Recently, carbonic anhydrase (CA) inhibitors have been proposed as a potential new class of antitumor agents. The aim of this study was to evaluate the antitumor activity of three CA inhibitors, namely acetazolamide (AZ)...
- Novel Small-Molecule Inhibitor of Apurinic/Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces Viability of Glioblastoma Cells
[作者:Bapat, A; Glass, LS; Luo, MH; Fishel, ML; Long, EC; Georgiadis, MM; Kelley, MR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:988-998 , 文章类型: Article,,卷期:2010年334-3]
- Apurinic/apyrimidinic (AP) endonuclease 1 (Ape1) is an essential DNA repair protein that plays a critical role in repair of AP sites via base excision repair. Ape1 has received attention as a druggable oncotherapeutic ta...
- Ivermectin Antagonizes Ethanol Inhibition in Purinergic P2X4 Receptors
[作者:Asatryan, L; Popova, M; Perkins, D; Trudell, JR; Alkana, RL; Davies, DL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:720-728 , 文章类型: Article,,卷期:2010年334-3]
- ATP-gated purinergic P2X4 receptors (P2X4Rs) are expressed in the central nervous system and are sensitive to ethanol at intoxicating concentrations. P2XRs are trimeric; each subunit consists of two transmembrane (TM) al...
- Reversal of TNP-470-Induced Endothelial Cell Growth Arrest by Guanine and Guanine Nucleosides
[作者:Hines, J; Ju, R; Dutschman, GE; Cheng, YC; Crews, CM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:729-738 , 文章类型: Article,,卷期:2010年334-3]
- The mechanism of action of TNP-470 [O-(chloroacetyl-carbamoyl) fumagillol], which potently and selectively inhibits the proliferation of endothelial cells, is incompletely understood. Previous studies have established it...
- Long-Acting Phosphodiesterase-5 Inhibitor Tadalafil Attenuates Doxorubicin-Induced Cardiomyopathy without Interfering with Chemotherapeutic Effect
[作者:Koka, S; Das, A; Zhu, SG; Durrant, D; Xi, L; Kukreja, RC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1023-1030 , 文章类型: Article,,卷期:2010年334-3]
- Doxorubicin (DOX) is one of the most effective anticancer drugs. However, its cardiotoxicity remains a clinical concern that severely restricts its therapeutic usage. We designed this study to investigate whether tadalaf...
- Intrathecal Delivery of a Mutant mu-Opioid Receptor Activated by Naloxone as a Possible Antinociceptive Paradigm
[作者:Kao, JH; Chen, SL; Ma, HI; Law, PY; Tao, PL; Loh, HH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:739-745 , 文章类型: Article,,卷期:2010年334-3]
- Direct injection of double-stranded adeno-associated virus type 2 (dsAAV2) with a mu-opioid receptor (MOR) mutant [S4.45(196)A], and a reporter protein (enhanced green fluorescent protein) into the spinal cord (S2/S3) do...
- Characterization of the Calcitonin Gene-Related Peptide Receptor Antagonist Telcagepant (MK-0974) in Human Isolated Coronary Arteries
[作者:Chan, KY; Edvinsson, L; Eftekhari, S; Kimblad, PO; Kane, SA; Lynch, J; Hargreaves, RJ; de Vries, R; Garrelds, IM; van den Bogaerdt, AJ; Danser, AHJ; MaassenVanDenBrink, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:746-752 , 文章类型: Article,,卷期:2010年334-3]
- The sensory neuropeptide calcitonin gene-related peptide (CGRP) plays a role in primary headaches, and CGRP receptor antagonists are effective in migraine treatment. CGRP is a potent vasodilator, raising the possibility ...
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