- A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease
[作者:Matsuoka, Y; Jouroukhin, Y; Gray, AJ; Ma, L; Hirata-Fukae, C; Li, HF; Feng, L; Lecanu, L; Walker, BR; Planel, E; Arancio, O; Gozes, I; Aisen, PS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:146-153 , 文章类型: Article,,卷期:2008年325-1]
Neurofibrillary tangles composed of aggregated, hyperphosphorylated tau in an abnormal conformation represent one of the major pathological hallmarks of Alzheimer's disease (AD) and other tauopathies. However, recent ...
- Nanomolar propofol stimulates glutamate transmission to dopamine neurons: A possible mechanism of abuse potential?
[作者:Li, KY; Xiao, C; Xiong, M; Delphin, E; Ye, JH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:165-174 , 文章类型: Article,,卷期:2008年325-1]
Anesthesiologists among physicians are on the top of the drug abuse list, and the mechanism is unclear. Recent studies suggest occupation-related second-hand exposure to i.v. drugs, including propofol, may play a role...
- Orally available levosimendan dose-related positive inotropic and lusitropic effect in conscious chronically instrumented normal and heart failure dogs
[作者:Masutani, S; Cheng, HJ; Hyttila-Hopponen, M; Levijoki, J; Heikkila, A; Vuorela, A; Little, WC; Cheng, CP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:236-247 , 文章类型: Article,,卷期:2008年325-1]
Levosimendan (LS), a Ca2+ sensitizer, is presently limited to i.v. administration. The dose-related pharmacodynamic effects of newly developed oral LS remain undetermined. We assessed the dose-response relationship of...
- Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissue
[作者:Brighton, PJ; Wise, A; Dass, NB; Willars, GB,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:154-164 , 文章类型: Article,,卷期:2008年325-1]
Neuromedin U (NmU) is a neuropeptide showing high levels of structural conservation across different species. Since its discovery in 1985, NmU has been implicated in numerous physiological roles, including smooth musc...
- Aberrant splicing caused by single nucleotide polymorphism c.516G > T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver
[作者:Hofmann, MH; Blievernicht, JK; Klein, K; Saussele, T; Schaeffeler, E; Schwab, M; Zanger, UM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:284-292 , 文章类型: Article,,卷期:2008年325-1]
CYP2B6 is a polymorphic human drug metabolizing cytochrome P450 with clinical relevance for several drug substrates including cyclophosphamide, bupropion, and efavirenz. The common allele CYP2B6*6 [c. 516G > T, Q17...
- (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
[作者:Thomas, L; Eckhardt, M; Langkopf, E; Tadayyon, M; Himmelsbach, F; Mark, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:175-182 , 文章类型: Article,,卷期:2008年325-1]
BI 1356 [proposed trade name ONDERO; (R)-8-(3-aminopiperidin1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin2-ylmethyl)-3,7-dihydro-purine-2,6-dione] is a novel dipeptidyl peptidase (DPP)-4 inhibitor under clinical ...
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