- Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2
[作者:Buntinx, M; Hermans, B; Goossens, J; Moechars, D; Gilissen, RAHJ; Doyon, J; Boeckx, S; Coesemans, E; Van Lommen, G; Van Wauwe, JP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1-9 , 文章类型: Article,,卷期:2008年327-1]
The interaction between CC chemokine receptor 2 (CCR2) with monocyte chemoattractant proteins, such as MCP-1, regulates the activation and recruitment of inflammatory leukocytes. In this study, we characterized (S)-3-...
- Sodium hydrogen exchange 1 (NHE-1) regulates connexin 43 expression in cardiomyocytes via reverse mode sodium calcium exchange and c-Jun NH2-terminal kinase-dependent pathways
[作者:Stanbouly, S; Kirshenbaum, LA; Jones, DL; Karmazyn, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:105-113 , 文章类型: Article,,卷期:2008年327-1]
Connexin 43, the major connexin isoform in gap junctions of cardiac ventricular myocytes, undergoes changes in distribution and expression in cardiac diseases. The Na+-H+ exchanger (NHE-1), a key mediator of hypertrop...
- Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity
[作者:Amantini, C; Mosca, M; Lucciarini, R; Perfumi, MC; Santoni, G,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:215-225 , 文章类型: Article,,卷期:2008年327-1]
The activity of substance P (SP) in the rat thymus seems to be tightly controlled by its bioavailability. In this study, we provide evidence for the expression of the SP-degrading enzyme, neutral endopeptidase (NEP)/C...
- MDMA(3,4-methylenedioxymethamphetamine)-mediated distortion of somatosensory signal transmission and neurotransmitter efflux in the ventral posterior medial thalamus
[作者:Starr, MA; Page, ME; Waterhouse, BD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:20-31 , 文章类型: Article,,卷期:2008年327-1]
MDMA (3,4-methylenedioxymethamphetamine, Ecstasy) is reported to enhance tactile sensory perception, an effect that is believed to contribute to its popularity as a recreational drug. To date, no literature exists tha...
- Paraquat exposure reduces nicotinic receptor-evoked dopamine release in monkey striatum
[作者:O'Leary, KT; Parameswaran, N; Johnston, LC; McIntosh, JM; Di Monte, DA; Quik, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:124-129 , 文章类型: Article,,卷期:2008年327-1]
Paraquat, an herbicide widely used in the agricultural industry, has been associated with lung, liver, and kidney toxicity in humans. In addition, it is linked to an increased risk of Parkinson's disease. For this rea...
- Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells
[作者:Matsuda, T; Toyohira, Y; Ueno, S; Tsutsui, M; Yanagihara, N,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:130-136 , 文章类型: Article,,卷期:2008年327-1]
Simvastatin, an inhibitor of HMG-CoA reductase, is a potent inhibitor of cholesterol biosynthesis and has beneficial effects in the primary and secondary prevention of cardiovascular diseases. In this study, we report...
- Nonlinear pharmacokinetics of (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") and its major metabolites in squirrel monkeys at plasma concentrations of MDMA that develop after typical psychoactive doses
[作者:Mueller, M; Peters, FT; Maurer, HH; McCann, UD; Ricaurte, GA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:38-44 , 文章类型: Article,,卷期:2008年327-1]
At certain doses, the psychoactive drug (+/-)3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") destroys brain serotonin axon terminals. By causing increases in plasma MDMA concentrations that exceed those ...
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