- Discovery of Novel Selective Norepinephrine Reuptake Inhibitors: 4-[3-Aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231)
[作者:ONEILL DAVID J; ADEDOYIN ADEDAYO; ALFINITO PETER D; BRAY JENIFER A; COSMI SCOTT; DEECHER DARLENE C; FENSOME ANDREW; HARRISON JIM; LEVENTHAL LIZA; MANN CHARLES; MCCOMAS CASEY C; SULLIVAN NICOLE R; SPANGLER TAYLOR B; UVEGES ALBERT J; TRYBULSKI EUGENE J; WHITESIDE GARTH T; ZHANG PUWEN,期刊:Journal of Medicinal Chemistry, 页码:4511-4521 , 文章类型: Article,,卷期:2010年53-11]
- Structural modification of a virtual screening hit led to the identification of a new series of 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)bu tan-2-ols which are potent and selective inhibitors ...
- Rationale Design of Biotinylated Antimalarial Endoperoxide Carbon Centered Radical Prodrugs for Applications in Proteomics
[作者:BARTON VICTORIA; WARD STEVEN A; CHADWICK JAMES; HILL ALASDAIR; ONEILL PAUL M,期刊:Journal of Medicinal Chemistry, 页码:4555-4559 , 文章类型: Article,,卷期:2010年53-11]
- The semisynthetic artemisinin derivatives such as artesunate and artemether, along with the fully synthetic endoperoxide antimalarials (e.g., OZ277, Nature 2004, 430, 900-904), are believed to mediate their antimalarial ...
- Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors
[作者:WANG SHUDONG; MIDGLEY CAROL A; SCAEROU FREDERIC; GRABAREK JOANNA B; GRIFFITHS GARY; JACKSON WAYNE; KONTOPIDIS GEORGE; MCCLUE STEVEN J; MCINNES CAMPBELL; MEADES CHRISTOPHER; MEZNA MOKDAD; PLATER ANDY; STUART IAIN; THOMAS MARK P; WOOD GAVIN; CLARKE ROSEMARY G; BLAKE DAVID G; ZHELEVA DANIELLA I; LANE DAVID P; JACKSON ROBERT C; GLOVER DAVID M; FISCHER PETER M,期刊:Journal of Medicinal Chemistry, 页码:4367-4378 , 文章类型: Article,,卷期:2010年53-11]
- Through cell-based screening of our kinase-directed compound collection, we discovered that a subset of N-phenyl-4-(thiazol-5-yppyrimidin-2-amines were potent cytotoxic agents against cancer cell lines, suppressed mitoti...
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