- Tissue Factor-Activated Coagulation Cascade in the Tumor Microenvironment Is Critical for Tumor Progression and an Effective Target for Therapy
[作者：Liu, Y; Jiang, PF; Capkova, K; Xue, D; Ye, LW; Sinha, SC; Mackman, N; Janda, KD; Liu, C,期刊：Cancer research, 页码：6492-6502 , 文章类型： Article，,卷期：2011年71-20]
- Tissue factor (TF), a rate-limiting enzyme cofactor in activating coagulation, is highly expressed in a wide spectrum of human tumor and tumor stromal cells. Using TF-deficient cancer cells and a conditional TF-knockout ...
- Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors
[作者：Cai, CM; Chen, S; Ng, P; Bubley, GJ; Nelson, PS; Mostaghel, EA; Marck, B; Matsumoto, AM; Simon, NI; Wang, HY; Chen, SY; Balk, SP,期刊：Cancer research, 页码：6503-6513 , 文章类型： Article，,卷期：2011年71-20]
- Relapse of castration-resistant prostate cancer (CRPC) that occurs after androgen deprivation therapy of primary prostate cancer can be mediated by reactivation of the androgen receptor (AR). One important mechanism medi...
- Oncogene AEG-1 Promotes Glioma-Induced Neurodegeneration by Increasing Glutamate Excitotoxicity
[作者：Lee, SG; Kim, K; Kegelman, TP; Dash, R; Das, SK; Choi, JK; Emdad, L; Howlett, EL; Jeon, HY; Su, ZZ; Yoo, BK; Sarkar, D; Kim, SH; Kang, DC; Fisher, PB,期刊：Cancer research, 页码：6514-6523 , 文章类型： Article，,卷期：2011年71-20]
- Aggressive tumor growth, diffuse tissue invasion, and neurodegeneration are hallmarks of malignant glioma. Although glutamate excitotoxicity is considered to play a key role in glioma-induced neurodegeneration, the mecha...
- Treatment of Hematologic Malignancies with Immunotoxins and Antibody-Drug Conjugates
[作者：FitzGerald, DJ; Wayne, AS; Kreitman, RJ; Pastan, I,期刊：Cancer research, 页码：6300-6309 , 文章类型： Review，,卷期：2011年71-20]
- To enable antibodies to function as cytotoxic anticancer agents, they are modified either via attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules, termed immunotoxins and antibody-dr...
- Regulator of G Protein Signaling 6 Mediates Doxorubicin-Induced ATM and p53 Activation by a Reactive Oxygen Species-Dependent Mechanism
[作者：Huang, J; Yang, JQ; Maity, B; Mayuzumi, D; Fisher, RA,期刊：Cancer research, 页码：6310-6319 , 文章类型： Article，,卷期：2011年71-20]
- Doxorubicin (DXR), among the most widely used cancer chemotherapy agents, promotes cancer cell death via activation of ataxia telangiectasia mutated (ATM) and the resultant upregulation of tumor suppressor p53. The exact...
- Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers
[作者：Kogo, R; Shimamura, T; Mimori, K; Kawahara, K; Imoto, S; Sudo, T; Tanaka, F; Shibata, K; Suzuki, A; Komune, S; Miyano, S; Mori, M,期刊：Cancer research, 页码：6320-6326 , 文章类型： Article，,卷期：2011年71-20]
- The functional impact of recently discovered long noncoding RNAs (ncRNAs) in human cancer remains to be clarified. One long ncRNA which has attracted attention is the Hox transcript antisense intergenic RNA termed HOTAIR...
- Evolution of Tumor Invasiveness: The Adaptive Tumor Microenvironment Landscape Model
[作者：Lee, HO; Silva, AS; Concilio, S; Li, YS; Slifker, M; Gatenby, RA; Cheng, JD,期刊：Cancer research, 页码：6327-6337 , 文章类型： Article，,卷期：2011年71-20]
- Interactions between cancer cells and their microenvironment are crucial for promoting tumor growth and invasiveness. In the tumor adaptive landscape model, hypoxic and acidic microenvironmental conditions reduce the fit...
- p38 gamma Promotes Breast Cancer Cell Motility and Metastasis through Regulation of RhoC GTPase, Cytoskeletal Architecture, and a Novel Leading Edge Behavior
[作者：Rosenthal, DT; Iyer, H; Escudero, S; Bao, LW; Wu, ZF; Ventura, AC; Kleer, CG; Arruda, EM; Garikipati, K; Merajver, SD,期刊：Cancer research, 页码：6338-6349 , 文章类型： Article，,卷期：2011年71-20]
- Understanding the molecular alterations that confer cancer cells with motile, metastatic properties is needed to improve patient survival. Here, we report that p38 gamma motogen-activated protein kinase regulates breast ...
- Antiangiogenic Agent Sunitinib Transiently Increases Tumor Oxygenation and Suppresses Cycling Hypoxia
[作者：Matsumoto, S; Batra, S; Saito, K; Yasui, H; Choudhuri, R; Gadisetti, C; Subramanian, S; Devasahayam, N; Munasinghe, JP; Mitchell, JB; Krishna, MC,期刊：Cancer research, 页码：6350-6359 , 文章类型： Article，,卷期：2011年71-20]
- Structural and functional abnormalities in tumor blood vessels impact the delivery of oxygen and nutrients to solid tumors, resulting in chronic and cycling hypoxia. Although chronically hypoxic regions exhibit treatment...
- Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by beta 8 Integrin
[作者：Tchaicha, JH; Reyes, SB; Shin, J; Hossain, MG; Lang, FF; McCarty, JH,期刊：Cancer research, 页码：6371-6381 , 文章类型： Article，,卷期：2011年71-20]
- Glioblastoma multiforme (GBM) is a highly invasive brain tumor that develops florid microvascular proliferation and hemorrhage. However, mechanisms that favor invasion versus angiogenesis in this setting remain largely u...
- TLR9 Agonists Oppositely Modulate DNA Repair Genes in Tumor versus Immune Cells and Enhance Chemotherapy Effects
[作者：Sommariva, M; De Cecco, L; De Cesare, M; Sfondrini, L; Menard, S; Melani, C; Delia, D; Zaffaroni, N; Pratesi, G; Uva, V; Tagliabue, E; Balsari, A,期刊：Cancer research, 页码：6382-6390 , 文章类型： Article，,卷期：2011年71-20]
- Synthetic oligodeoxynucleotides expressing CpG motifs (CpG-ODN) are a Toll-like receptor 9 (TLR9) agonist that can enhance the antitumor activity of DNA-damaging chemotherapy and radiation therapy in preclinical mouse mo...
- Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer
[作者：de Chaisemartin, L; Goc, J; Damotte, D; Validire, P; Magdeleinat, P; Alifano, M; Cremer, I; Fridman, WH; Sautes-Fridman, C; Dieu-Nosjean, MC,期刊：Cancer research, 页码：6391-6399 , 文章类型： Article，,卷期：2011年71-20]
- De novo formation of tertiary lymphoid structures (TLS) has been described in lung cancers. Intratumoral TLS seem to be functional and are associated with a long-term survival for lung cancer patients, suggesting that th...
- Tumor-Associated Macrophages Mediate Immunosuppression in the Renal Cancer Microenvironment by Activating the 15-Lipoxygenase-2 Pathway
[作者：Daurkin, I; Eruslanov, E; Stoffs, T; Perrin, GQ; Algood, C; Gilbert, SM; Rosser, CJ; Su, LM; Vieweg, J; Kusmartsev, S,期刊：Cancer research, 页码：6400-6409 , 文章类型： Article，,卷期：2011年71-20]
- Renal cell carcinoma (RCC), the most common human kidney cancer, is frequently infiltrated with tumor-associated macrophages (TAM) that can promote malignant progression. Here, we show that TAMs isolated from human RCC p...
- IRF-1 Expression Is Essential for Natural Killer Cells to Suppress Metastasis
[作者：Ksienzyk, A; Neumann, B; Nandakumar, R; Finsterbusch, K; Grashoff, M; Zawatzky, R; Bernhardt, G; Hauser, H; Kroger, A,期刊：Cancer research, 页码：6410-6418 , 文章类型： Article，,卷期：2011年71-20]
- IFN-gamma promotes tumoral immune surveillance, but its involvement in controlling metastases is less clear. Using a mouse model of pulmonary metastases, we show that local IFN-gamma treatment inhibits formation of metas...
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