个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   Resistance to BRAF Inhibitors: Unraveling Mechanisms and Future Treatment Options [作者：Villanueva, J; Vultur, A; Herlyn, M,期刊：Cancer research, 页码：7137-7140 , 文章类型： Review，,卷期：2011年71-23] The mitogen-activated protein kinase (MAPK) pathway has emerged as a central target for melanoma therapy due to its persistent activation in the majority of tumors. Several BRAF inhibitors aimed at curbing MAPK pathway a... Diversity of Human Leukemia Xenograft Mouse Models: Implications for Disease Biology [作者：Meyer, LH; Debatin, KM,期刊：Cancer research, 页码：7141-7144 , 文章类型： Review，,卷期：2011年71-23] Over the past decade, xenografting human leukemia cells into mice with different levels of immunodeficiency, with or without preconditioning, has provided an important tool to study various aspects of leukemia biology an... The LMP7-K Allele of the Immunoproteasome Exhibits Reduced Transcript Stability and Predicts High Risk of Colon Cancer [作者：Fellerhoff, B; Gu, SH; Laumbacher, B; Nerlich, AG; Weiss, EH; Glas, J; Kopp, R; Johnson, JP; Wank, R,期刊：Cancer research, 页码：7145-7154 , 文章类型： Article，,卷期：2011年71-23] Destruction of cancer cells by cytotoxic T lymphocytes depends on immunogenic tumor peptides generated by proteasomes and presented by human leukocyte antigen (HLA) molecules. Functional differences arising from alleles ... Blockade of TGF-beta Signaling by the TGF beta R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma [作者：Zhang, M; Kleber, S; Rohrich, M; Timke, C; Han, N; Tuettenberg, J; Martin-Villalba, A; Debus, J; Peschke, P; Wirkner, U; Lahn, M; Huber, PE,期刊：Cancer research, 页码：7155-7167 , 文章类型： Article，,卷期：2011年71-23] Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor that tends to be resistant to the ionizing radiotherapy used to treat it. Because TGF-beta is a modifier of radiation responses, we conducted a pre... Multiple Stress Signals Activate Mutant p53 In Vivo [作者：Suh, YA; Post, SM; Elizondo-Fraire, AC; Maccio, DR; Jackson, JG; El-Naggar, AK; Van Pelt, C; Terzian, T; Lozano, G,期刊：Cancer research, 页码：7168-7175 , 文章类型： Article，,卷期：2011年71-23] p53 levels are tightly regulated in normal cells, and thus, the wild-type p53 protein is nearly undetectable until stimulated through a variety of stresses. In response to stress, p53 is released from its negative regula... Egfl7 Promotes Tumor Escape from Immunity by Repressing Endothelial Cell Activation [作者：Delfortrie, S; Pinte, S; Mattot, V; Samson, C; Villain, G; Caetano, B; Lauridant-Philippin, G; Baranzelli, MC; Bonneterre, J; Trottein, F; Faveeuw, C; Soncin, F,期刊：Cancer research, 页码：7176-7186 , 文章类型： Article，,卷期：2011年71-23] Downregulating the leukocyte adhesion molecules expressed by endothelial cells that line tumor blood vessels can limit the entry of immune effector cells into the tumor mass, thereby contributing to tumoral immune escape... Classification of Epstein-Barr Virus-Positive Gastric Cancers by Definition of DNA Methylation Epigenotypes [作者：Matsusaka, K; Kaneda, A; Nagae, G; Ushiku, T; Kikuchi, Y; Hino, R; Uozaki, H; Seto, Y; Takada, K; Aburatani, H; Fukayama, M,期刊：Cancer research, 页码：7187-7197 , 文章类型： Article，,卷期：2011年71-23] Epstein-Barr virus (EBV) is associated with Burkitt lymphoma, nasopharyngeal carcinoma, opportunistic lymphomas in immunocompromised hosts, and a fraction of gastric cancers. Aberrant promoter methylation accompanies hum... Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation [作者：Acquaviva, J; Jun, HJ; Lessard, J; Ruiz, R; Zhu, HH; Donovan, M; Woolfenden, S; Boskovitz, A; Raval, A; Bronson, RT; Pfannl, R; Whittaker, CA; Housman, DE; Al Charest,期刊：Cancer research, 页码：7198-7206 , 文章类型： Article，,卷期：2011年71-23] Glioblastoma multiforme (GBM) is characterized by overexpression of epidermal growth factor receptor (EGFR) and loss of the tumor suppressors Ink4a/Arf. Efforts at modeling GBM using wild-type EGFR in mice have proven un... Cooperative Phosphorylation of FADD by Aur-A and Plk1 in Response to Taxol Triggers Both Apoptotic and Necrotic Cell Death [作者：Jang, MS; Lee, SJ; Kang, NS; Kim, E,期刊：Cancer research, 页码：7207-7215 , 文章类型： Article，,卷期：2011年71-23] Administration of the antimitotic chemotherapeutic taxol is known to cause accumulation of the mitotic kinase Aurora-A (Aur-A). Here, we report that Aur-A phosphorylates S203 of the Fas associated with death domain prote... Cell-Permeable NM23 Blocks the Maintenance and Progression of Established Pulmonary Metastasis [作者：Lim, J; Jang, G; Kang, S; Lee, G; Nga, DTT; Phuong, DTL; Kim, H; El-Rifai, W; Ruley, HE; Jo, D,期刊：Cancer research, 页码：7216-7225 , 文章类型： Article，,卷期：2011年71-23] Occult metastases are a major cause of cancer mortality, even among patients undergoing curative resection. Therefore, practical strategies to target the growth and persistence of already established metastases would pro... STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells [作者：Lin, L; Liu, AG; Peng, ZG; Lin, HJ; Li, PK; Li, CL; Lin, JY,期刊：Cancer research, 页码：7226-7237 , 文章类型： Article，,卷期：2011年71-23] STAT3 is constitutively activated in colon cancer but its contributions in cancer-initiating cells have not been explored. In this study, we characterized STAT3 in aldehyde dehydrogenase (ALDH)-positive (ALDH(+)) and CD1... Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties [作者：Wang, J; Lu, F; Ren, Q; Sun, H; Xu, ZS; Lan, RF; Liu, YQ; Ward, D; Quan, JM; Ye, T; Zhang, H,期刊：Cancer research, 页码：7238-7249 , 文章类型： Article，,卷期：2011年71-23] Histone modification determines epigenetic patterns of gene expression with methylation of histone H3 at lysine 4 (H3K4) often associated with active promoters. LSD1/KDM1 is a histone demethylase that suppresses gene exp... Identification of Tumorigenic Cells in Kras(G12D)-Induced Lung Adenocarcinoma [作者：Cho, HC; Lai, CY; Shao, LE; Yu, J,期刊：Cancer research, 页码：7250-7258 , 文章类型： Article，,卷期：2011年71-23] We established an inducible Kras(G12D)-driven lung adenocarcinoma in CCSP-rtTA/TetO-Cre/LSL-Kras(G12D) mice that enable pursuits of the cellular and molecular processes involved in Kras-induced tumorigenesis. To investig... Lactoferrin-Endothelin-1 Axis Contributes to the Development and Invasiveness of Triple-Negative Breast Cancer Phenotypes [作者：Ha, NH; Nair, VS; Reddy, DNS; Mudvari, P; Ohshiro, K; Ghanta, KS; Pakala, SB; Li, DQ; Costa, L; Lipton, A; Badwe, RA; Fuqua, S; Wallon, M; Prendergast, GC; Kumar, R,期刊：Cancer research, 页码：7259-7269 , 文章类型： Article，,卷期：2011年71-23] Triple-negative breast cancer (TNBC) is characterized by the lack of expression of estrogen receptor-alpha (ER-alpha), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2). However, pathways r... Mucin Glycosylating Enzyme GALNT2 Regulates the Malignant Character of Hepatocellular Carcinoma by Modifying the EGF Receptor [作者：Wu, YM; Liu, CH; Hu, RH; Huang, MJ; Lee, JJ; Chen, CH; Huang, J; Lai, HS; Lee, PH; Hsu, WM; Huang, HC; Huang, MC,期刊：Cancer research, 页码：7270-7279 , 文章类型： Article，,卷期：2011年71-23] Extracellular glycosylation is a critical determinant of malignant character. Here, we report that N-acetylgalactosaminyltransferase 2 (GALNT2), the enzyme that mediates the initial step of mucin type-O glycosylation, is... Dishevelled 2 Signaling Promotes Self-Renewal and Tumorigenicity in Human Gliomas [作者：Pulvirenti, T; Van der Heijden, M; Droms, LA; Huse, JT; Tabar, V; Hall, A,期刊：Cancer research, 页码：7280-7290 , 文章类型： Article，,卷期：2011年71-23] Glioblastoma multiforme is the most common glioma variant in adults and is highly malignant. Tumors are thought to harbor a subpopulation of stem-like cancer cells, with the bulk resembling neural progenitor-like cells t...