- IGFBP-3 Is a Metastasis Suppression Gene in Prostate Cancer
[作者：Mehta, HH; Gao, QL; Galet, C; Paharkova, V; Wan, JX; Said, J; Sohn, JJ; Lawson, G; Cohen, P; Cobb, LJ; Lee, KW,期刊：Cancer research, 页码：5154-5163 , 文章类型： Article，,卷期：2011年71-15]
- The insulin-like growth factor binding protein IGFBP-3 is a proapoptotic and antiangiogenic protein in prostate cancer (CaP). Epidemiologic studies suggest that low IGFBP-3 is associated with greater risk of aggressive, ...
- F-18-Fluorodeoxy-glucose Positron Emission Tomography Marks MYC-Overexpressing Human Basal-Like Breast Cancers
[作者：Palaskas, N; Larson, SM; Schultz, N; Komisopoulou, E; Wong, J; Rohle, D; Campos, C; Yannuzzi, N; Osborne, JR; Linkov, I; Kastenhuber, ER; Taschereau, R; Plaisier, SB; Tran, C; Heguy, A; Wu, H; Sander, C; Phelps, ME; Brennan, C; Port, E; Huse, JT; Graeber, TG; Mellinghoff, IK,期刊：Cancer research, 页码：5164-5174 , 文章类型： Article，,卷期：2011年71-15]
- In contrast to normal cells, cancer cells avidly take up glucose and metabolize it to lactate even when oxygen is abundant, a phenomenon referred to as the Warburg effect. This fundamental alteration in glucose metabolis...
- Genetic Variation in an miRNA-1827 Binding Site in MYCL1 Alters Susceptibility to Small-Cell Lung Cancer
[作者：Xiong, F; Wu, C; Chang, J; Yu, DK; Xu, BH; Yuan, P; Zhai, K; Xu, J; Tan, W; Lin, DX,期刊：Cancer research, 页码：5175-5181 , 文章类型： Article，,卷期：2011年71-15]
- Genetic variations in microRNAs (miRNA) that affect control of their target genes may alter individual susceptibilities to cancer. In this study, we took an in silico approach to identify single-nucleotide polymorphisms ...
- Combining Betulinic Acid and Mithramycin A Effectively Suppresses Pancreatic Cancer by Inhibiting Proliferation, Invasion, and Angiogenesis
[作者：Gao, Y; Jia, ZL; Kong, XY; Li, Q; Chang, DZ; Wei, DY; Le, XD; Huang, SD; Huang, SY; Wang, LW; Xie, KP,期刊：Cancer research, 页码：5182-5193 , 文章类型： Article，,卷期：2011年71-15]
- Both betulinic acid (BA) and mithramycin A (MIT) exhibit potent antitumor activity through distinct mechanisms of Sp1 inhibition. However, it is unknown whether a combination of these two compounds results in a synergist...
- BMP4 Promotes Prostate Tumor Growth in Bone through Osteogenesis
[作者：Lee, YC; Cheng, CJ; Bilen, MA; Lu, JF; Satcher, RL; Yu-Lee, LY; Gallick, GE; Maity, SN; Lin, SH,期刊：Cancer research, 页码：5194-5203 , 文章类型： Article，,卷期：2011年71-15]
- Induction of new bone formation is frequently seen in the bone lesions from prostate cancer. However, whether osteogenesis is necessary for prostate tumor growth in bone is unknown. Recently, 2 xenografts, MDA-PCa-118b a...
- Akt-Dependent Glucose Metabolism Promotes Mcl-1 Synthesis to Maintain Cell Survival and Resistance to Bcl-2 Inhibition
[作者：Coloff, JL; Macintyre, AN; Nichols, AG; Liu, TY; Gallo, CA; Plas, DR; Rathmell, JC,期刊：Cancer research, 页码：5204-5213 , 文章类型： Article，,卷期：2011年71-15]
- Most cancer cells utilize aerobic glycolysis, and activation of the phosphoinositide 3-kinase/Akt/mTOR pathway can promote this metabolic program to render cells glucose dependent. Although manipulation of glucose metabo...
- MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma
[作者：Ibrahim, AF; Weirauch, U; Thomas, M; Grunweller, A; Hartmann, RK; Aigner, A,期刊：Cancer research, 页码：5214-5224 , 文章类型： Article，,卷期：2011年71-15]
- MicroRNAs (miRNA) aberrantly expressed in tumors may offer novel therapeutic approaches to treatment. miR-145 is downregulated in various cancers including colon carcinoma in which in vitro studies have established proap...
- Combined Gene Expression Profiling and RNAi Screening in Clear Cell Renal Cell Carcinoma Identify PLK1 and Other Therapeutic Kinase Targets
[作者：Ding, Y; Huang, D; Zhang, ZF; Smith, J; Petillo, D; Looyenga, BD; Feenstra, K; MacKeigan, JP; Furge, KA; Teh, BT,期刊：Cancer research, 页码：5225-5234 , 文章类型： Article，,卷期：2011年71-15]
- In recent years, several molecularly targeted therapies have been approved for clear cell renal cell carcinoma (ccRCC), a highly aggressive cancer. Although these therapies significantly extend overall survival, nearly a...
- Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy
[作者：Rountree, RB; Mandl, SJ; Nachtwey, JM; Dalpozzo, K; Do, L; Lombardo, JR; Schoonmaker, PL; Brinkmann, K; Dirmeier, U; Laus, R; Delcayre, A,期刊：Cancer research, 页码：5235-5244 , 文章类型： Article，,卷期：2011年71-15]
- MVA-BN-PRO (BN ImmunoTherapeutics) is a candidate immunotherapy product for the treatment of prostate cancer. It encodes 2 tumor-associated antigens, prostate-specific antigen (PSA), and prostatic acid phosphatase (PAP),...
- Retinoic Acid Enhances TRAIL-Induced Apoptosis in Cancer Cells by Upregulating TRAIL Receptor 1 Expression
[作者：Dhandapani, L; Yue, P; Ramalingam, SS; Khuri, FR; Sun, SY,期刊：Cancer research, 页码：5245-5254 , 文章类型： Article，,卷期：2011年71-15]
- Many human cancer cells are sensitive to killing by the proapoptotic ligand TNF-related apoptosis-inducing ligand (TRAIL), which is under study for cancer treatment in clinical trials. The TRAIL receptor (TRAIL-R1; also ...
- A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients
[作者：Tiedt, R; Degenkolbe, E; Furet, P; Appleton, BA; Wagner, S; Schoepfer, J; Buck, E; Ruddy, DA; Monahan, JE; Jones, MD; Blank, J; Haasen, D; Drueckes, P; Wartmann, M; McCarthy, C; Sellers, WR; Hofmann, F,期刊：Cancer research, 页码：5255-5264 , 文章类型： Article，,卷期：2011年71-15]
- The emergence of drug resistance is a primary concern in any cancer treatment, including with targeted kinase inhibitors as exemplified by the appearance of Bcr-Abl point mutations in chronic myeloid leukemia (CML) patie...
- Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3 beta and CDK1
[作者：Mayes, PA; Dolloff, NG; Daniel, CJ; Liu, JJ; Hart, LS; Kuribayashi, K; Allen, JE; Jee, DIH; Dorsey, JF; Liu, YQY; Dicker, DT; Brown, JM; Furth, EE; Klein, PS; Sears, RC; El-Deiry, WS,期刊：Cancer research, 页码：5265-U264 , 文章类型： Article，,卷期：2011年71-15]
- Tumor hypoxia is an inherent impediment to cancer treatment that is both clinically significant and problematic. In this study, we conducted a cell-based screen to identify small molecules that could reverse the apoptoti...
- Interleukin-1 alpha Mediates the Antiproliferative Effects of 1,25-Dihydroxyvitamin D-3 in Prostate Progenitor/Stem Cells
[作者：Maund, SL; Barclay, WW; Hover, LD; Axanova, LS; Sui, GC; Hipp, JD; Fleet, JC; Thorburn, A; Cramer, SD,期刊：Cancer research, 页码：5276-5286 , 文章类型： Article，,卷期：2011年71-15]
- Vitamin D-3 is a promising preventative and therapeutic agent for prostate cancer, but its implementation is hampered by a lack of understanding about its mechanism of action. Upon treatment with 1 alpha,25-dihydroxyvita...
- PTEN Positively Regulates UVB-Induced DNA Damage Repair
[作者：Ming, M; Feng, L; Shea, CR; Soltani, K; Zhao, BZ; Han, WN; Smart, RC; Trempus, CS; He, YY,期刊：Cancer research, 页码：5287-5295 , 文章类型： Article，,卷期：2011年71-15]
- Nonmelanoma skin cancer is the most common cancer in the United States, where DNA-damaging ultraviolet B (UVB) radiation from the sun remains the major environmental risk factor. However, the critical genetic targets of ...
- IL-8 Signaling Plays a Critical Role in the Epithelial-Mesenchymal Transition of Human Carcinoma Cells
[作者：Fernando, RI; Castillo, MD; Litzinger, M; Hamilton, DH; Palena, C,期刊：Cancer research, 页码：5296-5306 , 文章类型： Article，,卷期：2011年71-15]
- The switch of tumor cells from an epithelial to a mesenchymal-like phenotype [designated as epithelial-to-mesenchymal transition (EMT)] is known to induce tumor cell motility and invasiveness, therefore promoting metasta...
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