- Comparison of Neuropathy-Inducing Effects of Eribulin Mesylate, Paclitaxel, and Ixabepilone in Mice
[作者：Wozniak, KM; Nomoto, K; Lapidus, RG; Wu, Y; Carozzi, V; Cavaletti, G; Hayakawa, K; Hosokawa, S; Towle, MJ; Littlefield, BA; Slusher, BS,期刊：Cancer research, 页码：3952-3962 , 文章类型： Article，,卷期：2011年71-11]
- Chemotherapy-induced neurotoxicity is a significant problem associated with successful treatment of many cancers. Tubulin is a well-established target of antineoplastic therapy; however, tubulin-targeting agents, such as...
- Convection-Enhanced Delivery of Topotecan into a PDGF-Driven Model of Glioblastoma Prolongs Survival and Ablates Both Tumor-Initiating Cells and Recruited Glial Progenitors
[作者：Lopez, KA; Tannenbaum, AM; Assanah, MC; Linskey, K; Yun, J; Kangarlu, A; Gil, OD; Canoll, P; Bruce, JN,期刊：Cancer research, 页码：3963-3971 , 文章类型： Article，,卷期：2011年71-11]
- The contribution of microenvironment to tumor growth has important implications for optimizing chemotherapeutic response and understanding the biology of recurrent tumors. In this study, we tested the effects of locally ...
- 6-Bromoindirubin-3 '-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
[作者：Liu, L; Nam, S; Tian, Y; Yang, F; Wu, J; Wang, Y; Scuto, A; Polychronopoulos, P; Magiatis, P; Skaltsounis, L; Jove, R,期刊：Cancer research, 页码：3972-3979 , 文章类型： Article，,卷期：2011年71-11]
- STAT3 is persistently activated and contributes to malignant progression in various cancers. Janus activated kinases (JAK) phosphorylate STAT3 in response to stimulation by cytokines or growth factors. The STAT3 signalin...
- Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness
[作者：Hong, J; Zhou, J; Fu, JJ; He, T; Qin, J; Wang, L; Liao, L; Xu, JM,期刊：Cancer research, 页码：3980-3990 , 文章类型： Article，,卷期：2011年71-11]
- Twist1, a basic helix-loop-helix transcription factor, promotes breast tumor cell epithelial-mesenchymal transition (EMT), invasiveness, and metastasis. However, the mechanisms responsible for regulating Twist1 stability...
- Aldehyde Dehydrogenase in Combination with CD133 Defines Angiogenic Ovarian Cancer Stem Cells That Portend Poor Patient Survival
[作者：Silva, IA; Bai, SM; McLean, K; Yang, K; Griffith, K; Thomas, D; Ginestier, C; Johnston, C; Kueck, A; Reynolds, RK; Wicha, MS; Buckanovich, RJ,期刊：Cancer research, 页码：3991-4001 , 文章类型： Article，,卷期：2011年71-11]
- Markers that reliably identify cancer stem cells (CSC) in ovarian cancer could assist prognosis and improve strategies for therapy. CD133 is a reported marker of ovarian CSC. Aldehyde dehydrogenase (ALDH) activity is a r...
- Hedgehog Overexpression Is Associated with Stromal Interactions and Predicts for Poor Outcome in Breast Cancer
[作者：O'Toole, SA; Machalek, DA; Shearer, RF; Millar, EKA; Nair, R; Schofield, P; McLeod, D; Cooper, CL; McNeil, CM; McFarland, A; Nguyen, A; Ormandy, CJ; Qiu, MR; Rabinovich, B; Martelotto, LG; Vu, D; Hannigan, GE; Musgrove, EA; Christ, D; Sutherland, RL; Watk,期刊：Cancer research, 页码：4002-4014 , 文章类型： Article，,卷期：2011年71-11]
- Hedgehog (Hh) signaling plays an important role in several malignancies but its clinical significance in breast cancer is unclear. In a cohort of 279 patients with invasive ductal carcinoma of the breast, expression of H...
- The Hypoxia-Associated Factor Switches Cells from HIF-1 alpha- to HIF-2 alpha-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
[作者：Koh, MY; Lemos, R; Liu, XP; Powis, G,期刊：Cancer research, 页码：4015-4027 , 文章类型： Article，,卷期：2011年71-11]
- Most solid tumors and their metastases experience periods of low oxygen or hypoxia, which is of major clinical significance as it promotes both tumor progression and resistance to therapy. Critical mediators of the hypox...
- EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes beta-Catenin-Dependent Hepatocarcinogenesis
[作者：Cheng, ASL; Lau, SS; Chen, YC; Kondo, Y; Li, MS; Feng, H; Ching, AK; Cheung, KF; Wong, HK; Tong, JH; Jin, HC; Choy, KW; Yu, J; To, KF; Wong, N; Huang, THM; Sung, JJY,期刊：Cancer research, 页码：4028-4039 , 文章类型： Article，,卷期：2011年71-11]
- Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2) that represses gene transcription through histone H3 lysine 27 trimethylation (H3K27me3). Although EZH2 is abundantl...
- Serial Magnetic Resonance Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma
[作者：Kim, H; Catana, C; Ratai, EM; Andronesi, OC; Jennings, DL; Batchelor, TT; Jain, RK; Sorensen, AG,期刊：Cancer research, 页码：3745-3752 , 文章类型： Article，,卷期：2011年71-11]
- Proton magnetic resonance spectroscopy is increasingly used in clinical studies of brain tumor to provide information about tissue metabolic profiles. In this study, we evaluated changes in the levels of metabolites pred...
- Preclinical Validation of Electrochemotherapy as an Effective Treatment for Brain Tumors
[作者：Agerholm-Larsen, B; Iversen, HK; Ibsen, P; Moller, JM; Mahmood, F; Jensen, KS; Gehl, J,期刊：Cancer research, 页码：3753-3762 , 文章类型： Article，,卷期：2011年71-11]
- Electrochemotherapy represents a strategy to enhance chemotherapeutic drug uptake by delivering electrical pulses which exceed the dielectric strength of the cell membrane, causing transient formation of structures that ...
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