- Targeting the EGFR signaling pathway in cancer therapy
[作者:Seshacharyulu, P; Ponnusamy, MP; Haridas, D; Jain, M; Ganti, AK; Batra, SK,期刊:Expert Opinion on Therapeutic Targets, 页码:15-31 , 文章类型: Review,,卷期:2012年16-1]
- Introduction: Cancer is a devastating disease; however, several therapeutic advances have recently been made, wherein EGFR and its family members have emerged as useful biomarkers and therapeutic targets. EGFR, a transme...
- Targeting the Hedgehog signaling pathway for cancer therapy
[作者:Li, YW; Maitah, MY; Ahmad, A; Kong, D; Bao, B; Sarkar, FH,期刊:Expert Opinion on Therapeutic Targets, 页码:49-66 , 文章类型: Review,,卷期:2012年16-1]
- Introduction: Hedgehog (Hh) signaling pathway plays key roles in embryonic development, formation and maintenance of cancer stem cells (CSCs) and acquisition of epithelial-to-mesenchymal transition (EMT). Since CSCs and ...
- Targeting the PI3K signaling pathway in cancer therapy
[作者:Bartholomeusz, C; Gonzalez-Angulo, AM,期刊:Expert Opinion on Therapeutic Targets, 页码:121-130 , 文章类型: Review,,卷期:2012年16-1]
- Introduction: The PI3K signaling pathway is involved in the regulation of cancer cell growth, motility, survival and metabolism. The pathway is frequently active in many different types of cancer-e. g., breast, bladder, ...
- Targeting embryonic signaling pathways in cancer therapy
[作者:Harris, PJ; Speranza, G; Ullmann, CD,期刊:Expert Opinion on Therapeutic Targets, 页码:131-145 , 文章类型: Review,,卷期:2012年16-1]
- Introduction: The embryonic signaling pathways (ESP), Hedgehog, Notch and Wnt, are critical for the regulation of normal stem cells and cellular development processes. They are also activated in the majority of cancers. ...
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