- LL37 and hBD-3 elevate the beta-1,3-exoglucanase activity of Candida albicans Xog1p, resulting in reduced fungal adhesion to plastic
[作者:Chang, HT; Tsai, PW; Huang, HH; Liu, YS; Chien, TS; Lan, CY,期刊:Biochemical Journal, 页码:963-970 , 文章类型: Article,,卷期:2012年441-3]
- The opportunistic fungus Candida albicans causes oral thrush and vaginal candidiasis, as well as candidaemia in immunocompromised patients including those undergoing cancer chemotherapy, organ transplant and those with A...
- Dynamic measurements of mitochondrial hydrogen peroxide concentration and glutathione redox state in rat pancreatic beta-cells using ratiometric fluorescent proteins: confounding effects of pH with HyPer but not roGFP1
[作者:Roma, LP; Duprez, J; Takahashi, HK; Gilon, P; Wiederkehr, A; Jonas, JC,期刊:Biochemical Journal, 页码:971-978 , 文章类型: Article,,卷期:2012年441-3]
- Using the ROS (reactive oxygen species)-sensitive fluorescent dyes dichlorodihydrofluorescein and dihydroethidine, previous studies yielded opposite results about the glucose regulation of oxidative stress in insulin-sec...
- Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNF alpha-induced cancer cell migration
[作者:Xiao, N; Li, H; Luo, J; Wang, R; Chen, HQ; Chen, JQ; Wang, P,期刊:Biochemical Journal, 页码:979-986 , 文章类型: Article,,卷期:2012年441-3]
- TRAF [TNF (tumour necrosis factor)-receptor-associated factor] 2 and 6 are essential adaptor proteins for the NF-kappa B (nuclear factor kappa B) signalling pathway, which play important roles in inflammation and immune ...
- Crystallographic and X-ray absorption spectroscopic characterization of Helicobacter pylori UreE bound to Ni2+ and Zn2+ reveals a role for the disordered C-terminal arm in metal trafficking
[作者:Banaszak, K; Martin-Diaconescu, V; Bellucci, M; Zambelli, B; Rypniewski, W; Maroney, MJ; Ciurli, S,期刊:Biochemical Journal, 页码:1017-1026 , 文章类型: Article,,卷期:2012年441-3]
- The survival and growth of the pathogen Helicobacter pylori in the gastric acidic environment is ensured by the activity of urease, an enzyme containing two essential Ni2+ ions in the active site. The metallo-chaperone U...
- The multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities
[作者:Brook, M; McCracken, L; Reddington, JP; Lu, ZL; Morrice, NA; Gray, NK,期刊:Biochemical Journal, 页码:803-812 , 文章类型: Article,,卷期:2012年441-3]
- PABP1 [poly(A)-binding protein 1] is a central regulator of mRNA translation and stability and is required for miRNA (microRNA)-mediated regulation and nonsense-mediated decay. Numerous protein, as well as RNA, interacti...
- Induction of oxidative stress, lysosome activation and autophagy by nanoparticles in human brain-derived endothelial cells
[作者:Kenzaoui, BH; Bernasconi, CC; Guney-Ayra, S; Juillerat-Jeanneret, L,期刊:Biochemical Journal, 页码:813-821 , 文章类型: Article,,卷期:2012年441-3]
- Different types of NPs (nanoparticles) are currently under development for diagnostic and therapeutic applications in the biomedical field, yet our knowledge about their possible effects and fate in living cells is still...
- Identification of persulfide-binding and disulfide-forming cysteine residues in the NifS-like domain of the molybdenum cofactor sulfurase ABA3 by cysteine-scanning mutagenesis
[作者:Lehrke, M; Rump, S; Heidenreich, T; Wissing, J; Mendel, RR; Bittner, F,期刊:Biochemical Journal, 页码:823-832 , 文章类型: Article,,卷期:2012年441-3]
- The Moco (molybdenum cofactor) sulfurase ABA3 from Arabidopsis thaliana catalyses the sulfuration of the Moco of aldehyde oxidase and xanthine oxidoreductase, which represents the final activation step of these enzymes. ...
- The full-length Streptococcus pneumoniae major pilin RrgB crystallizes in a fibre-like structure, which presents the D1 isopeptide bond and provides details on the mechanism of pilus polymerization
[作者:El Mortaji, L; Contreras-Martel, C; Moschioni, M; Ferlenghi, I; Manzano, C; Vernet, T; Dessen, A; Di Guilmi, AM,期刊:Biochemical Journal, 页码:833-841 , 文章类型: Article,,卷期:2012年441-3]
- RrgB is the major pilin which forms the pneumococcal pilus backbone. We report the high-resolution crystal structure of the full-length form of RrgB containing the IPQTG sorting motif. The RrgB fold is organized into fou...
- Modulation of glucokinase by glucose, small-molecule activator and glucokinase regulatory protein: steady-state kinetic and cell-based analysis
[作者:Bourbonais, FJ; Chen, J; Huang, C; Zhang, YW; Pfefferkorn, JA; Landro, JA,期刊:Biochemical Journal, 页码:881-887 , 文章类型: Article,,卷期:2012年441-3]
- GK (glucokinase) is an enzyme central to glucose metabolism that displays positive co-operativity to substrate glucose. Small-molecule GKAs (GK activators) modulate GK catalytic activity and glucose affinity and are curr...
- Abi-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion
[作者:Maruoka, M; Sato, M; Yuan, YF; Ichiba, M; Fuji, R; Ogawa, T; Ishida-Kitagawa, N; Takeya, T; Watanabe, N,期刊:Biochemical Journal, 页码:889-899 , 文章类型: Article,,卷期:2012年441-3]
- Mena [mammalian Ena (Enabled)]/VASP (vasodilator-stimulated phosphoprotein) proteins are the homologues of Drosophila Ena. In Drosophila, Ena is a substrate of the tyrosine kinase DAbl (Drosophila Abl). However, the link...
- A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes
[作者:Dube, H; Selwood, D; Malouitre, S; Capano, M; Simone, MI; Crompton, M,期刊:Biochemical Journal, 页码:901-907 , 文章类型: Article,,卷期:2012年441-3]
- Mitochondrial CyP-D (cyclophilin-D) catalyses formation of the PT (permeability transition) pore, a key lesion in the pathogenesis of I/R (ischaemia/reperfusion) injury. There is evidence [Malouitre, Dube, Selwood and Cr...
- Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression
[作者:Hurst, NJ; Najy, AJ; Ustach, CV; Movilla, L; Kim, HRC,期刊:Biochemical Journal, 页码:909-918 , 文章类型: Article,,卷期:2012年441-3]
- The PDGF (platelet-derived growth factor) family members are potent mitogens for cells of mesenchymal origin and serve as important regulators of cell migration, survival, apoptosis and transformation. Tumour-derived PDG...
- BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1
[作者:Dohrn, L; Salles, D; Siehler, SY; Kaufmann, J; Wiesmuller, L,期刊:Biochemical Journal, 页码:919-926 , 文章类型: Article,,卷期:2012年441-3]
- BACH1 (BRCA1-associated C-terminal helicase 1), the product of the BRIP1 {BRCA1 [breast cancer 1, early onset]-interacting protein C-terminal helicase 1; also known as FANCJ [FA-J (Fanconi anaemia group J) protein]} gene...
- Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes
[作者:Hjerpe, R; Thomas, Y; Chen, J; Zemla, A; Curran, S; Shpiro, N; Dick, LR; Kurz, T,期刊:Biochemical Journal, 页码:927-936 , 文章类型: Article,,卷期:2012年441-3]
- Ubiquitin and UBL (ubiquitin-like) modifiers are small proteins that covalently modify other proteins to alter their properties or behaviours. Ubiquitin modification (ubiquitylation) targets many substrates, often leadin...
|