- Delivery of serotonin to the brain by monocytes following phagocytosis of liposomes
[作者:Afergan, E; Epstein, H; Dahan, R; Koroukhov, N; Rohekar, K; Danenberg, HD; Golomb, G,期刊:Journal of controlled release, 页码:84-90 , 文章类型: Article,,卷期:2008年132-2]
- Many drugs are not able to enter the brain due to the presence of the blood-brain barrier (BBB) and therefore cannot be used in the treatment of diseases of the brain. Since it is now known that the brain is under immuno...
- Pulsatile drug delivery to ileo-colonic segments by structured incorporation of disintegrants in pH-responsive polymer coatings
[作者:Schellekens, RCA; Stellaard, F; Mitrovic, D; Stuurman, FE; Kosterink, JGW; Frijlink, HW,期刊:Journal of controlled release, 页码:91-98 , 文章类型: Article,,卷期:2008年132-2]
- Conventional pH-responsive coatings used for oral drug delivery to the lower parts of the gastro-intestinal tract often show a poor performance. A new system for site-specific pulsatile delivery in the ileo-colonic regio...
- In vivo gene delivery in the mouse lung with lactosylated polyethylenimine, questioning the relevance of in vitro experiments
[作者:Grosse, S; Thevenot, G; Aron, Y; Duverger, E; Abdelkarim, M; Roche, AC; Monsigny, M; Fajac, I,期刊:Journal of controlled release, 页码:105-112 , 文章类型: Article,,卷期:2008年132-2]
- Polyethylenimine (PEI) is an efficient vector for in vitro and in vivo gene transfer into respiratory cells. Glycosylated PEIs were shown to enhance in vitro gene transfer by favoring the complex entry into the airway ce...
- Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS
[作者:Cardoso, ALC; Simoes, S; de Almeida, LP; Plesnila, N; de Lima, MCP; Wagner, E; Culmsee, C,期刊:Journal of controlled release, 页码:113-123 , 文章类型: Article,,卷期:2008年132-2]
- Although RNAi-based gene silencing holds a great potential for treatment of neurological disorders, its application to the CNS has been restricted by low levels of tissue distribution and cellular uptake. In this work we...
- Delivery of siRNA into the cytoplasm by liposomal bubbles and ultrasound
[作者:Negishi, Y; Endo, Y; Fukuyama, T; Suzuki, R; Takizawa, T; Omata, D; Maruyama, K; Aramaki, Y,期刊:Journal of controlled release, 页码:124-130 , 文章类型: Article,,卷期:2008年132-2]
- Small interfering RNA (siRNA) is expected to be a novel therapeutic tool, however, its utilization has been limited by inefficient delivery systems. Recently, we have developed novel polyethyleneglycol modified liposomes...
- Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs
[作者:Lin, YH; Sonaje, K; Lin, KM; Juang, JH; Mi, FL; Yang, HW; Sung, HW,期刊:Journal of controlled release, 页码:141-149 , 文章类型: Article,,卷期:2008年132-2]
- pH-Responsive nanoparticles composed of chitosan (G) and poly-gamma-glutamic acid (-y-PGA) blended with tripolyphosphate (TPP) and MgSO4 (multi-ion-crosslinked NPs) were prepared and characterized to determine their effe...
- Cell microencapsulation technology: Towards clinical application
[作者:Murua, A; Portero, A; Orive, G; Hernandez, RM; de Castro, M; Pedraz, JL,期刊:Journal of controlled release, 页码:76-83 , 文章类型: Review,,卷期:2008年132-2]
- The pharmacokinetic properties of a drug can be significantly improved by the delivery process. Scientists have understood that developing suitable drug delivery systems that release the therapeutically active molecule a...
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