- High Levels of Costimulatory Receptors OX40 and 4-1BB Characterize CD4(+)CD28(null) T Cells in Patients With Acute Coronary Syndrome
[作者:Dumitriu, IE; Baruah, P; Finlayson, CJ; Loftus, IM; Antunes, RF; Lim, P; Bunce, N; Kaski, JC,期刊:Circulation Research, 页码:857-U150 , 文章类型: Article,,卷期:2012年110-6]
- Rationale: Patients with acute coronary syndrome (ACS) predisposed to recurrent coronary events have an expansion of a distinctive T-cell subset, the CD4(+)CD28(null) T cells. These cells are highly inflammatory and cyto...
- Lymphocytes and the Adventitial Immune Response in Atherosclerosis
[作者:Campbell, KA; Lipinski, MJ; Doran, AC; Skaflen, MD; Fuster, V; McNamara, CA,期刊:Circulation Research, 页码:889-900 , 文章类型: Review,,卷期:2012年110-6]
- Although much of the research on atherosclerosis has focused on the intimal accumulation of lipids and inflammatory cells, there is an increasing amount of interest in the role of the adventitia in coordinating the immun...
- Homocysteine Upregulates Soluble Epoxide Hydrolase in Vascular Endothelium In Vitro and In Vivo
[作者:Zhang, DH; Xie, XN; Chen, YQ; Hammock, BD; Kong, W; Zhu, Y,期刊:Circulation Research, 页码:808-U43 , 文章类型: Article,,卷期:2012年110-6]
- Rationale: Hyperhomocysteinemia is a risk factor of atherogenesis. Soluble epoxide hydrolase (sEH) is a major enzyme that hydrolyzes epoxyeicosatrienoic acids and attenuates their cardiovascular protective effects. Wheth...
- CIP, a Cardiac Isl1-Interacting Protein, Represses Cardiomyocyte Hypertrophy
[作者:Huang, ZP; Seok, HY; Zhou, B; Chen, JH; Chen, JF; Tao, YZ; Pu, WT; Wang, DZ,期刊:Circulation Research, 页码:818-U66 , 文章类型: Article,,卷期:2012年110-6]
- Rationale: Mammalian heart has minimal regenerative capacity. In response to mechanical or pathological stress, the heart undergoes cardiac remodeling. Pressure and volume overload in the heart cause increased size (hype...
- Hyperphosphorylation of the Cardiac Ryanodine Receptor at Serine 2808 Is Not Involved in Cardiac Dysfunction After Myocardial Infarction
[作者:Zhang, HY; Makarewich, CA; Kubo, H; Wang, W; Duran, JM; Li, Y; Berretta, RM; Koch, WJ; Chen, XW; Gao, EH; Valdivia, HH; Houser, SR,期刊:Circulation Research, 页码:831-U87 , 文章类型: Article,,卷期:2012年110-6]
- Rationale: Abnormal behavior of the cardiac ryanodine receptor (RyR2) has been linked to cardiac arrhythmias and heart failure (HF) after myocardial infarction (MI). It has been proposed that protein kinase A (PKA) hyper...
- Ranolazine Improves Cardiac Diastolic Dysfunction Through Modulation of Myofilament Calcium Sensitivity
[作者:Lovelock, JD; Monasky, MM; Jeong, EM; Lardin, HA; Liu, H; Patel, BG; Taglieri, DM; Gu, LZ; Kumar, P; Pokhrel, N; Zeng, DW; Belardinelli, L; Sorescu, D; Solaro, RJ; Dudley, SC,期刊:Circulation Research, 页码:841-U114 , 文章类型: Article,,卷期:2012年110-6]
- Rationale: Previously, we demonstrated that a deoxycorticosterone acetate (DOCA)-salt hypertensive mouse model produces cardiac oxidative stress and diastolic dysfunction with preserved systolic function. Oxidative stres...
- Absence of Type VI Collagen Paradoxically Improves Cardiac Function, Structure, and Remodeling After Myocardial Infarction
[作者:Luther, DJ; Thodeti, CK; Shamhart, PE; Adapala, RK; Hodnichak, C; Weihrauch, D; Bonaldo, P; Chilian, WM; Meszaros, JG,期刊:Circulation Research, 页码:851-U125 , 文章类型: Article,,卷期:2012年110-6]
- Rationale: We previously reported that type VI collagen deposition increases in the infarcted myocardium in vivo. To date, a specific role for this nonfibrillar collagen has not been explored in the setting of myocardial...
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