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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Ups delivery to the intermembrane space of mitochondria: a novel affinity-driven protein import pathway [作者：Herrmann, JM,期刊：EMBO journal, 页码：2859-2860 , 文章类型： Editorial Material，,卷期：2010年29-17] MEK signalling tunes actin treadmilling for interstitial lymphocyte migration [作者：Weber, M; Sixt, M,期刊：EMBO journal, 页码：2861-2863 , 文章类型： Editorial Material，,卷期：2010年29-17] When lymphocytes follow chemotactic cues, they can adopt different migratory modes depending on the geometry and molecular composition of their extracellular environment. In this issue of The EMBO Journal, Klemke et al (... Mechanisms and regulation of DNA end resection [作者：Longhese, MP; Bonetti, D; Manfrini, N; Clerici, M,期刊：EMBO journal, 页码：2864-2874 , 文章类型： Review，,卷期：2010年29-17] DNA double-strand breaks (DSBs) are highly hazardous for genome integrity, because failure to repair these lesions can lead to genomic instability. DSBs can arise accidentally at unpredictable locations into the genome, ... Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation [作者：Tamura, Y; Iijima, M; Sesaki, H,期刊：EMBO journal, 页码：2875-2887 , 文章类型： Article，,卷期：2010年29-17] Ups1p, Ups2p, and Ups3p are three homologous proteins that control phospholipid metabolism in the mitochondrial intermembrane space (IMS). The Ups proteins are atypical IMS proteins in that they lack the two major IMS-ta... Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35 [作者：Potting, C; Wilmes, C; Engmann, T; Osman, C; Langer, T,期刊：EMBO journal, 页码：2888-2898 , 文章类型： Article，,卷期：2010年29-17] The mitochondrial phospholipid metabolism critically depends on members of the conserved Ups1/PRELI-like protein family in the intermembrane space. Ups1 and Ups2 (also termed Gep1) were shown to regulate the accumulation... Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites [作者：Grotsch, H; Giblin, JP; Idrissi, FZ; Fernandez-Golbano, IM; Collette, JR; Newpher, TM; Robles, V; Lemmon, SK; Geli, MI,期刊：EMBO journal, 页码：2899-2914 , 文章类型： Article，,卷期：2010年29-17] Myosins-I are conserved proteins that bear an N-terminal motor head followed by a Tail Homology 1 (TH1) lipid-binding domain. Some myosins-I have an additional C-terminal extension (C-ext) that promotes Arp2/3 complex-de... An MEK-cofilin signalling module controls migration of human T cells in 3D but not 2D environments [作者：Klemke, M; Kramer, E; Konstandin, MH; Wabnitz, GH; Samstag, Y,期刊：EMBO journal, 页码：2915-2929 , 文章类型： Article，,卷期：2010年29-17] T cells infiltrate peripheral tissues to execute immunosurveillance and effector functions. For this purpose, T cells first migrate on the two-dimensional (2D) surface of endothelial cells to undergo transendothelial mig... Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase [作者：Bishop, A; Lane, R; Beniston, R; Chapa-y-Lazo, B; Smythe, C; Sudbery, P,期刊：EMBO journal, 页码：2930-2942 , 文章类型： Article，,卷期：2010年29-17] Polarized growth is a fundamental property of cell growth and development. It requires the delivery of post-Golgi secretory vesicles to the site of polarized growth. This process is mediated by Rab GTPases activated by t... Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains [作者：Reynoird, N; Schwartz, BE; Delvecchio, M; Sadoul, K; Meyers, D; Mukherjee, C; Caron, C; Kimura, H; Rousseaux, S; Cole, PA; Panne, D; French, CA; Khochbin, S,期刊：EMBO journal, 页码：2943-2952 , 文章类型： Article，,卷期：2010年29-17] In a subset of poorly differentiated and highly aggressive carcinoma, a chromosomal translocation, t(15;19)(q13;p13), results in an in-frame fusion of the double bromodomain protein, BRD4, with a testis-specific protein ... Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments [作者：Li, HC; Liu, XS; Yang, XM; Wang, YM; Wang, Y; Turner, JR; Liu, XQ,期刊：EMBO journal, 页码：2953-2965 , 文章类型： Article，,卷期：2010年29-17] CLIP-170 is implicated in the formation of kinetochore-microtubule attachments through direct interaction with the dynein/dynactin complex. However, whether this important function of CLIP-170 is regulated by phosphoryla... IKK and NF-kappa B-mediated regulation of Claspin impacts on ATR checkpoint function [作者：Kenneth, NS; Mudie, S; Rocha, S,期刊：EMBO journal, 页码：2966-2978 , 文章类型： Article，,卷期：2010年29-17] In response to replication stress, Claspin mediates the phosphorylation and activation of Chk1 by ATR. Claspin is not only necessary for the propagation of the DNA-damage signal, but its destruction by the ubiquitin-prot... Arabidopsis S6 kinase mutants display chromosome instability and altered RBR1-E2F pathway activity [作者：Henriques, R; Magyar, Z; Monardes, A; Khan, S; Zalejski, C; Orellana, J; Szabados, L; de la Torre, C; Koncz, C; Bogre, L,期刊：EMBO journal, 页码：2979-2993 , 文章类型： Article，,卷期：2010年29-17] The 40S ribosomal protein S6 kinase (S6K) is a conserved component of signalling pathways controlling growth in eukaryotes. To study S6K function in plants, we isolated single-and double-knockout mutations and RNA-interf... S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response [作者：Lai, KP; Leong, WF; Chau, JFL; Jia, DY; Zeng, L; Liu, HJ; He, L; Hao, AJ; Zhang, HB; Meek, D; Velagapudi, C; Habib, SL; Li, BJ,期刊：EMBO journal, 页码：2994-3006 , 文章类型： Article，,卷期：2010年29-17] p53 mediates DNA damage-induced cell-cycle arrest, apoptosis, or senescence, and it is controlled by Mdm2, which mainly ubiquitinates p53 in the nucleus and promotes p53 nuclear export and degradation. By searching for t... Telomere capping in non-dividing yeast cells requires Yku and Rap1 [作者：Vodenicharov, MD; Laterreur, N; Wellinger, RJ,期刊：EMBO journal, 页码：3007-3019 , 文章类型： Article，,卷期：2010年29-17] The assembly of a protective cap onto the telomeres of eukaryotic chromosomes suppresses genomic instability through inhibition of DNA repair activities that normally process accidental DNA breaks. We show here that the ... ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons [作者：Kuhn, PH; Wang, H; Dislich, B; Colombo, A; Zeitschel, U; Ellwart, JW; Kremmer, E; Rossner, S; Lichtenthaler, SF,期刊：EMBO journal, 页码：3020-3032 , 文章类型： Article，,卷期：2010年29-17] The amyloid precursor protein (APP) undergoes constitutive shedding by a protease activity called alpha-secretase. This is considered an important mechanism preventing the generation of the Alzheimer's disease amyloid-be... PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock (vol 29, pg 1903, 2010) [作者：Wang, L; Fujiwara, S; Somers, DE,期刊：EMBO journal, 页码：3033-3033 , 文章类型： Correction，,卷期：2010年29-17]