Ispronicline is a novel agonist at neuronal nicotinic alcetylcholine alpha 4 beta 2 receptors (nAChRs), which are involved in cognition. It has little affinity for peripheral muscle or ganglionic nAChRs. A wide variet...

Immunoglobulin G(1), anti-(respiratory syncytial virus glycoprotein F) (human-mouse monoclonal MEDI-524 gamma 1-chain), disulfide with human-mouse monoclonal MEDI-524 K-chain, dimer Immunoglobulin G(1), anti-(human re...

The cannabinoid CB1 receptor, a G-protein-coupled receptor expressed in the nervous system, has been linked to the control of food intake and energy expenditure in a variety of studies. The CB1 receptor inverse agonis...

Active specific immunization against cancer is a compelling concept which has been under investigatation for several decades. Among tumor vaccine approaches, a modified vaccinia Ankara (MVA) virus vector encoding the ...

A major problem in traditional cancer treatment is the severe toxic side effects of chemotherapy. One approach to increasing drug specificity revolves around the receptors for certain peptide hormones that are aberran...

A comprehensive mechanistic understanding of the apoptotic cell death pathway has led to intervention strategies (e.g., caspase inhibitors) that showed promise in attenuating tissue injury in animal models of human di...

This month's Filling the Gaps in Drug Therapy focuses on oculodentodigital dysplasia (ODDD), a rare inherited disorder caused by mutations in the gap junction protein connexin 43 (Cx43). Patients with this disease suf...

Protease-activated receptors (PARs) are a novel family of seven-transmembrane G-protein-coupled receptors. The unique feature of this family is that activation is initiated by cleavage of the N-terminus by serine or o...

The 3rd International Conference on Polyphenols and Health (ICPH), held in Kyoto, Japan, on November 25-28, 2007, focused on recent advances in polyphenolic research in different fields, from natural characterization,...