Several methodologies based on the aza-Wittig reaction, mainly developed by our research group, have been used for the preparation of a wide variety of ferrocenes containing nitrogen functionalities. Syntheses of mononuc...
Starting from Boc-activated diketopiperazines, original bicyclic derivatives of trans- and cis-2-aminocyclopentane-carboxylic acid were prepared by using two stereospecific tandem reactions. One of them is a tandem trans...
The C-N coupling between nucleophiles and aryl chlorides, which are less expensive, less reactive, and more abundant than their bromide and iodide counterparts, is challenging but of great interest for industrial applica...
PhSCF(2)CF(2)SiMe(3) (1) was developed as a tandem anion and radical tetrafluoroethylene equivalent for the introduction of a CF(2)CF(2) moiety. Fluoride-initiated nucleophilic additions of 1 to carbonyl compounds provid...
Diazine-bridged bisindoles are readily obtained from N-Boc-protected 3-iodoindoles and 3-iodo-7-azaindole in a pseudo three-component reaction involving a one-pot Masuda borylation-Suzuki arylation sequence. Some of the ...
The enantioselective Friedel Crafts fluoroalkylation of indoles with fluoroalkylated nitroalkenes, catalyzed by chiral phosphoric acid is described. The regioselectivity of fluoroalkylated nitroalkenes is a problem worth...
Acyclic amines 1 were obtained by a nucleophilic aromatic substitution (S(N)Ar) reaction and N-methylation followed by silane reduction. The optical resolution of C(aryl)-N(amine) bond atropisomers of amines 1 is describ...
Four sterane hydrocarbons were prepared for comparison with fossil organic biomarkers in geological samples from Oman. 17 beta-Methylestrane was prepared in six steps (36% overall yield) from estrone methyl ether. Key st...
An efficient one-pot synthesis of multi-functionalized chromeno[2,3-c]pyrrol-9(2H)-ones from 1,3-diaryl-1,3-diketones and amino acids is described. The synthesis is based on the 4-(dimethylamino)pyridine-catalyzed Baker-...
Perylene-3,4:9,10-tetracarboxylic acid bisimide represents a particularly attractive building block for DNA-based multichromophores and nanoassemblies due to its unique combination of optical and electronic properties. D...
The unique core structure of the complex pentacyclic 5,11-methanomorphanthridine has been constructed stereospecifically in one step by an intramolecular [3+2] cycloaddition of a non-stabilized azomethine ylide (AMY), ge...
Alternating benzene-heteroaryl oligomers possess fascinating optoelectronic properties and a wide range of applications. This article presents the facile synthesis of benzene-pyrrole oligomers with diverse functional gro...
The substrate scope of the gold-catalyzed cyclization of nonterminal propargylic amides to oxazolines and oxazines was investigated. Sixteen alkyl-substituted and 35 aryl-substited substrates were prepared by a very vari...
An enantioselective asymmetric total synthesis of (+)-vittatalactone has been accomplished employing enzymatic desymmetrization approach to create two methyl chiral centres. Other key steps involved are Wittig reaction, ...
Four novel Zn(2+) fluorescent sensors have been designed with N,N-bis(2-pyridylmethyl)ethylenediamine as chelator and 2-aminobenzamide as fluorophore. These sensors were prepared in two or three steps from readily availa...
A fully palladium-catalyzed synthesis of unusual naphthoxindole alkaloids through a key intramolecular direct C-H arylation step leading to the formation of the phenanthrene core is described. The three-step process invo...