- Novel Spirotetracyclic Zwitterionic Dual H-1/5-HT2A Receptor Antagonists for the Treatment of Sleep Disorders
[作者:GIANOTTI MASSIMO; BOTTA MAURIZIO; BROUGH STEPHEN; CARLETTI RENZO; CASTIGLIONI EMILIANO; CORTI CORRADO; DALCIN MICHELE; DELLE FRATTE SONIA; KORAJAC DENANA; LOVRIC MARIJA; MERLO GIANCARLO; MESIC MILAN; PAVONE FRANCESCA; PICCOLI LAURA; RAST SLAVKO; ROSCIC MAJA; SAVA ANNA; SMEHIL MARIO; STASI LUIGI; TOGNINELLI ANDREA; WIGGLESWORTH MARK J,期刊:Journal of Medicinal Chemistry, 页码:7778-7795 , 文章类型: Article,,卷期:2010年53-21]
- Histamine H-1 and serotonin 5-HT2A receptors mediate two different mechanisms involved in sleep regulation: H-1 antagonists are sleep inducers, while 5-HT2A antagonists are sleep maintainers. Starting from 9'a, a novel s...
- New Fluoro Derivatives of the Pyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxide System: Evaluation of Fluorine Binding Properties in the Benzodiazepine Site on gamma-Aminobutyrric Acid Type A (GABA(A)) Receptor. Design, Synthesis, Biological, and Molecular Modeling Investigation
[作者:GUERRINI GABRIELLA; CICIANI GIOVANNA; BRUNI FABRIZIO; SELLERI SILVIA; GUARINO CHIARA; MELANI FABRIZIO; MONTALI MARINA; DANIELE SIMONA; MARTINI CLAUDIA; GHELARDINI CARLA; NORCINI MONICA; CIATTINI SAMUELE; COSTANZO ANNARELLA,期刊:Journal of Medicinal Chemistry, 页码:7532-7548 , 文章类型: Article,,卷期:2010年53-21]
- In the search for potent ligands at the benzodiazepine site on the GABA(A) receptor, new fluoro derivatives of the pyrazolo[5,1-c][1,2,4]benzotriazine system were synthesized to evaluate the importance of the introductio...
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