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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共19条记录   STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation [作者：Muik, M; Fahrner, M; Schindl, R; Stathopulos, P; Frischauf, I; Derler, I; Plenk, P; Lackner, B; Groschner, K; Ikura, M; Romanin, C,期刊：EMBO journal, 页码：1678-1689 , 文章类型： Article，,卷期：2011年30-9] Stromal interaction molecule (STIM1) and ORAI1 are key components of the Ca2+ release-activated Ca2+ (CRAC) current having an important role in T-cell activation and mast cell degranulation. CRAC channel activation occur... Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain [作者：Kosodo, Y; Suetsugu, T; Suda, M; Mimori-Kiyosue, Y; Toida, K; Baba, SA; Kimura, A; Matsuzaki, F,期刊：EMBO journal, 页码：1690-1704 , 文章类型： Article，,卷期：2011年30-9] A hallmark of neurogenesis in the vertebrate brain is the apical-basal nuclear oscillation in polarized neural progenitor cells. Known as interkinetic nuclear migration (INM), these movements are synchronized with the ce... beta 1 integrins regulate fibroblast chemotaxis through control of N-WASP stability [作者：King, SJ; Worth, DC; Scales, TME; Monypenny, J; Jones, GE; Parsons, M,期刊：EMBO journal, 页码：1705-1718 , 文章类型： Article，,卷期：2011年30-9] Chemotactic migration of fibroblasts towards growth factors, such as during development and wound healing, requires precise spatial coordination of receptor signalling. However, the mechanisms regulating this remain poor... Lateral density of receptor arrays in the membrane plane influences sensitivity of the E. coli chemotaxis response [作者：Khursigara, CM; Lan, GH; Neumann, S; Wu, XW; Ravindran, S; Borgnia, MJ; Sourjik, V; Milne, J; Tu, Y; Subramaniam, S,期刊：EMBO journal, 页码：1719-1729 , 文章类型： Article，,卷期：2011年30-9] In chemotactic bacteria, transmembrane chemoreceptors, CheA and CheW form the core signalling complex of the chemotaxis sensory apparatus. These complexes are organized in extended arrays in the cytoplasmic membrane that... MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases [作者：Filippi, BM; de los Heros, P; Mehellou, Y; Navratilova, I; Gourlay, R; Deak, M; Plater, L; Toth, R; Zeqiraj, E; Alessi, DR,期刊：EMBO journal, 页码：1730-1741 , 文章类型： Article，,卷期：2011年30-9] Mouse protein-25 (MO25) isoforms bind to the STRAD pseudokinase and stabilise it in a conformation that can activate the LKB1 tumour suppressor kinase. We demonstrate that by binding to several STE20 family kinases, MO25... T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1 [作者：Staal, J; Driege, Y; Bekaert, T; Demeyer, A; Muyllaert, D; Van Damme, P; Gevaert, K; Beyaert, R,期刊：EMBO journal, 页码：1742-1752 , 文章类型： Article，,卷期：2011年30-9] The paracaspase mucosa-associated lymphoid tissue 1 (MALT1) is central to lymphocyte activation and lymphomagenesis. MALT1 mediates antigen receptor signalling to NF-kappa B by acting as a scaffold protein. Furthermore, ... Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence [作者：Homig-Holzel, C; Van Doorn, R; Vogel, C; Germann, M; Cecchini, MG; Verdegaal, E; Peeper, DS,期刊：EMBO journal, 页码：1753-1765 , 文章类型： Article，,卷期：2011年30-9] Oncogene-induced cellular senescence (OIS) is an increasingly recognized tumour suppressor mechanism that confines the outgrowth of neoplastic cells in vivo. It relies on a complex signalling network, but only few compon... Genome-wide characterization of chromatin binding and nucleosome spacing activity of the nucleosome remodelling ATPase ISWI [作者：Sala, A; Toto, M; Pinello, L; Gabriele, A; Di Benedetto, V; Ingrassia, AMR; Lo Bosco, G; Di Gesu, V; Giancarlo, R; Corona, DFV,期刊：EMBO journal, 页码：1766-1777 , 文章类型： Article，,卷期：2011年30-9] The evolutionarily conserved ATP-dependent nucleosome remodelling factor ISWI can space nucleosomes affecting a variety of nuclear processes. In Drosophila, loss of ISWI leads to global transcriptional defects and to dra... Constitutive heterochromatin reorganization during somatic cell reprogramming [作者：Fussner, E; Djuric, U; Strauss, M; Hotta, A; Perez-Iratxeta, C; Lanner, F; Dilworth, FJ; Ellis, J; Bazett-Jones, DP,期刊：EMBO journal, 页码：1778-1789 , 文章类型： Article，,卷期：2011年30-9] Induced pluripotent stem (iPS) cell reprogramming is a gradual epigenetic process that reactivates the pluripotent transcriptional network by erasing and establishing repressive epigenetic marks. In contrast to loci-spec... The nuclear RNA polymerase II surveillance system targets polymerase III transcripts [作者：Wlotzka, W; Kudla, G; Granneman, S; Tollervey, D,期刊：EMBO journal, 页码：1790-1803 , 文章类型： Article，,卷期：2011年30-9] A key question in nuclear RNA surveillance is how target RNAs are recognized. To address this, we identified in vivo binding sites for nuclear RNA surveillance factors, Nrd1, Nab3 and the Trf4/5-Air1/2-Mtr4 polyadenylati... Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes [作者：Pisareva, VP; Skabkin, MA; Hellen, CUT; Pestova, TV; Pisarev, AV,期刊：EMBO journal, 页码：1804-1817 , 文章类型： Article，,卷期：2011年30-9] No-go decay (NGD) and non-stop decay (NSD) are eukaryotic surveillance mechanisms that target mRNAs on which elongation complexes (ECs) are stalled by, for example, stable secondary structures (NGD) or due to the absence... Mechanisms of pseudosubstrate inhibition of the anaphase promoting complex by Acm1 [作者：Burton, JL; Xiong, Y; Solomon, MJ,期刊：EMBO journal, 页码：1818-1829 , 文章类型： Article，,卷期：2011年30-9] The anaphase promoting complex (APC) is a ubiquitin ligase that promotes the degradation of cell-cycle regulators by the 26S proteasome. Cdc20 and Cdh1 are WD40-containing APC co-activators that bind destruction boxes (D... E. coli DNA replication in the absence of free beta clamps [作者：Tanner, NA; Tolun, G; Loparo, JJ; Jergic, S; Griffith, JD; Dixon, NE; van Oijen, AM,期刊：EMBO journal, 页码：1830-1840 , 文章类型： Article，,卷期：2011年30-9] During DNA replication, repetitive synthesis of discrete Okazaki fragments requires mechanisms that guarantee DNA polymerase, clamp, and primase proteins are present for every cycle. In Escherichia coli, this process pro... Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres [作者：VerMilyea, MD; Maneck, M; Yoshida, N; Blochberger, I; Suzuki, E; Suzuki, T; Spang, R; Klein, CA; Perry, ACF,期刊：EMBO journal, 页码：1841-1851 , 文章类型： Article，,卷期：2011年30-9] Transcriptome regionalization is an essential polarity determinant among metazoans, directing embryonic axis formation during normal development. Although conservation of this principle in mammals is assumed, recent evid... Two types of chloride transporters are required for GABA(A) receptor-mediated inhibition in C. elegans [作者：Bellemer, A; Hirata, T; Romero, MF; Koelle, MR,期刊：EMBO journal, 页码：1852-1863 , 文章类型： Article，,卷期：2011年30-9] Chloride influx through GABA-gated Cl- channels, the principal mechanism for inhibiting neural activity in the brain, requires a Cl- gradient established in part by K+-Cl- cotransporters (KCCs). We screened for Caenorhab... Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development [作者：Biber, K; Tsuda, M; Tozaki-Saitoh, H; Tsukamoto, K; Toyomitsu, E; Masuda, T; Boddeke, H; Inoue, K,期刊：EMBO journal, 页码：1864-1873 , 文章类型： Article，,卷期：2011年30-9] Up-regulation of P2X4 receptors in spinal cord microglia is crucial for tactile allodynia, an untreatable pathological pain reaction occurring after peripheral nerve injury. How nerve injury in the periphery leads to thi...