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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   An interview with Robert J. Lefkowitz [作者：Lefkowitz, RJ,期刊：Trends in Pharmacological Sciences, 页码：51-52 , 文章类型： Editorial Material，,卷期：2012年33-2] InterfERing with endoplasmic reticulum stress [作者：Kraskiewicz, H; FitzGerald, U,期刊：Trends in Pharmacological Sciences, 页码：53-63 , 文章类型： Review，,卷期：2012年33-2] Stress to the endoplasmic reticulum (ER) is a recognized factor in Alzheimer's and Parkinson's diseases, diabetes, heart disease, liver disorders and cancer. Thus, drugs that interfere with ER stress have wide therapeuti... Inhibitors of membranous adenylyl cyclases [作者：Seifert, R; Lushington, GH; Mou, TC; Gille, A; Sprang, SR,期刊：Trends in Pharmacological Sciences, 页码：64-78 , 文章类型： Review，,卷期：2012年33-2] Membranous adenylyl cyclases (mACs) constitute a family of nine isoforms with different expression patterns. Studies with mAC gene knockout mice provide evidence for the notion that AC isoforms play distinct (patho)-phys... Domain coupling in GPCRs: the engine for induced conformational changes [作者：Unal, H; Karnik, SS,期刊：Trends in Pharmacological Sciences, 页码：79-88 , 文章类型： Review，,卷期：2012年33-2] Recent solved structures of G protein-coupled receptors (GPCRs) provide insights into variation of the structure and molecular mechanisms of GPCR activation. In this review, we provide evidence for the emerging paradigm ... Emerging cellular targets for influenza antiviral agents [作者：Muller, KH; Kakkola, L; Nagaraj, AS; Cheltsov, AV; Anastasina, M; Kainov, DE,期刊：Trends in Pharmacological Sciences, 页码：89-99 , 文章类型： Review，,卷期：2012年33-2] At the global level, influenza A virus (IAV) is considered a major health threat because it causes significant morbidity. Different treatment and prevention options have been developed; however, these are insufficient in... Functions of OATP1A and 1B transporters in vivo: insights from mouse models [作者：Iusuf, D; van de Steeg, E; Schinkel, AH,期刊：Trends in Pharmacological Sciences, 页码：100-108 , 文章类型： Review，,卷期：2012年33-2] Organic anion-transporting polypeptides (OATPs) are a superfamily of uptake transporters that mediate the cellular uptake of a broad range of endogenous and exogenous compounds. Of these OATP transporters, members of the... Yeast two-hybrid methods and their applications in drug discovery [作者：Hamdi, A; Colas, P,期刊：Trends in Pharmacological Sciences, 页码：109-118 , 文章类型： Review，,卷期：2012年33-2] The yeast two-hybrid (Y2H) method was first described over 20 years ago. It soon appeared as a major methodological breakthrough in the discovery and analysis of protein interactions, which play a pivotal role in all bio...