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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   An interview with P. Jeffrey Conn [作者：Conn, PJ,期刊：Trends in Pharmacological Sciences, 页码：119-121 , 文章类型： Editorial Material，,卷期：2012年33-3] Targeting Src family kinases in anti-cancer therapies: turning promise into triumph [作者：Zhang, SY; Yu, DH,期刊：Trends in Pharmacological Sciences, 页码：122-128 , 文章类型： Review，,卷期：2012年33-3] Src is a non-receptor tyrosine kinase that is deregulated in many types of cancer. Decades of research have revealed the crucial role of Src in many aspects of tumor development, including proliferation, survival, adhesi... Heat shock response and insulin-associated neurodegeneration [作者：Urban, MJ; Dobrowsky, RT; Blagg, BSJ,期刊：Trends in Pharmacological Sciences, 页码：129-137 , 文章类型： Review，,卷期：2012年33-3] Dysfunctional insulin and insulin-like growth factor-I (IGF-I) signaling contributes to the pathological progression of diabetes, diabetic peripheral neuropathy (DPN), Alzheimer's (AD), Parkinson's (PD) and Huntington's ... A 3D view if autotaxin [作者：Nishimasu, H; Ishitani, R; Aoki, J; Nureki, O,期刊：Trends in Pharmacological Sciences, 页码：138-145 , 文章类型： Review，,卷期：2012年33-3] Autotaxin (ATX), also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2), is a secreted lysophospholipase D (lysoPLD) that generates the lipid mediator lysophosphatidic acid (LPA), which in turn activate... Place your BETs: the therapeutic potential of bromodomains [作者：Prinjha, RK; Witherington, J; Lee, K,期刊：Trends in Pharmacological Sciences, 页码：146-153 , 文章类型： Review，,卷期：2012年33-3] Therapeutic targeting of the processes that regulate histone modification is a growing area of scientific exploration. Although most interest has concentrated on the various families of enzymes that contribute to these p... GRK2: multiple roles beyond G protein-coupled receptor desensitization [作者：Evron, T; Daigle, TL; Caron, MG,期刊：Trends in Pharmacological Sciences, 页码：154-164 , 文章类型： Review，,卷期：2012年33-3] G protein-coupled receptor kinases (GRKs) regulate numerous G protein-coupled receptors (GPCRs) by phosphorylating the intracellular domain of the active receptor, resulting in receptor desensitization and internalizatio... Utilizing placebo mechanisms for dose reduction in pharmacotherapy [作者：Doering, BK; Rief, W,期刊：Trends in Pharmacological Sciences, 页码：165-172 , 文章类型： Review，,卷期：2012年33-3] The knowledge and systematic application of the placebo effect remains limited, although its importance to the treatment of various medical conditions has increasingly been recognized. A possible application of the place...