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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   The Valley of Death in anticancer drug development: a reassessment [作者：Adams, DJ,期刊：Trends in Pharmacological Sciences, 页码：173-180 , 文章类型： Review，,卷期：2012年33-4] The past decade has seen an explosion in our understanding of cancer biology and with it many new potential disease targets. Nonetheless, our ability to translate these advances into therapies is poor, with a failure rat... Anandamide uptake explained? [作者：Fowler, CJ,期刊：Trends in Pharmacological Sciences, 页码：181-185 , 文章类型： Review，,卷期：2012年33-4] The endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol are removed from the extracellular space by a process of cellular uptake followed by metabolism. Although the enzymes responsible for endocannabinoid metab... Peptides for cell-selective drug delivery [作者：Svensen, N; Walton, JGA; Bradley, M,期刊：Trends in Pharmacological Sciences, 页码：186-192 , 文章类型： Review，,卷期：2012年33-4] The ability to target specific cell types to achieve optimal distribution of therapeutic entities into diseased tissues, while limiting possible adverse off-target effects, has long been a goal of many research groups an... Sniffing out pharmacology: interactions of drugs with human olfaction [作者：Lotsch, J; Geisslinger, G; Hummel, T,期刊：Trends in Pharmacological Sciences, 页码：193-199 , 文章类型： Review，,卷期：2012年33-4] Advances in the understanding of the sense of smell have increased awareness of the role of olfaction in human life. Odors are perceived via specific G protein-coupled receptors (GPCRs) with cAMP as the second messenger.... Once initiated, how does toxic tissue injury expand? [作者：Mehendale, HM,期刊：Trends in Pharmacological Sciences, 页码：200-206 , 文章类型： Review，,卷期：2012年33-4] Once initiated, how tissue injury expands after high toxicant doses, even after their complete elimination, is not understood. Free-radical generation was initially proposed to mediate progression of injury. However, mec... Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy [作者：Semenza, GL,期刊：Trends in Pharmacological Sciences, 页码：207-214 , 文章类型： Review，,卷期：2012年33-4] Hypoxia-inducible factors (HIFs) mediate adaptive physiological responses to hypoxia. In human cancers that are accessible for O(2) electrode measurements, intratumoral hypoxia is common and severe hypoxia is associated ... Lipid-anchored drugs for delivery into subcellular compartments [作者：Rajendran, L; Udayar, V; Goodger, ZV,期刊：Trends in Pharmacological Sciences, 页码：215-222 , 文章类型： Review，,卷期：2012年33-4] Bioavailability is a quantitative measure of the capacity of a drug to reach systemic circulation. However, if a drug target is localized in a subcellular organelle, then the drug may not be able to reach it and the effe...