个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共10条记录   Targeting mitotic exit for cancer treatment [作者：Wasch, R,期刊：Expert Opinion on Therapeutic Targets, 页码：785-788 , 文章类型： Editorial Material，,卷期：2011年15-7] Several chemotherapeutic drugs interfere with assembly of the mitotic spindle of cancer cells, leading to mitotic arrest, mediated by the spindle assembly checkpoint (SAC). However, cancer cells may be SAC-deficient and ... Coordinating electrical activity of the heart: ankyrin polypeptides in human cardiac disease [作者：Curran, J; Mohler, PJ,期刊：Expert Opinion on Therapeutic Targets, 页码：789-801 , 文章类型： Review，,卷期：2011年15-7] Areas covered: The roles of ankyrin polypeptides in excitation--contraction coupling in the heart and the development of ankyrin-specific cardiomyopathies. How ankyrin polypeptides may be involved in structural and elect... New molecular targets beyond KIT and PDGFRA in gastrointestinal stromal tumors: present and future [作者：Nannini, M; Biasco, G; Maleddu, A; Pantaleo, MA,期刊：Expert Opinion on Therapeutic Targets, 页码：803-815 , 文章类型： Review，,卷期：2011年15-7] Areas covered: The first aim of this review is to describe new targets and drugs in GISTs, alone or in combination, both in pre-clinical and clinical settings. The second aim is to discuss the criticism in this field, th... Overcoming drug resistance in pancreatic cancer [作者：Long, J; Zhang, YQ; Yu, XJ; Yang, JX; LeBrun, DG; Chen, CY; Yao, QZ; Li, M,期刊：Expert Opinion on Therapeutic Targets, 页码：817-828 , 文章类型： Review，,卷期：2011年15-7] Areas covered: Previous studies have indicated various mechanisms of drug resistance in pancreatic cancer, including changes in individual genes or signaling pathways, the influence of the tumor microenvironment, and the... Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy [作者：Heinzle, C; Sutterluty, H; Grusch, M; Grasl-Kraupp, B; Berger, W; Marian, B,期刊：Expert Opinion on Therapeutic Targets, 页码：829-846 , 文章类型： Review，,卷期：2011年15-7] Areas covered : Information from these sources as well as ongoing work from the authors' groups is used to outline the physiological functions of FGF signaling and to highlight how the high oncogenic effects of deregulat... Targeting neurotrophin-3 and its dependence receptor tyrosine kinase receptor C: a new antitumoral strategy [作者：Tauszig-Delamasure, S; Bouzas-Rodriguez, J,期刊：Expert Opinion on Therapeutic Targets, 页码：847-858 , 文章类型： Review，,卷期：2011年15-7] Areas covered: The role of neurotrophin-3 (NT-3) and its dependence receptor TrkC in neuroblastoma, and its suitability as a therapeutic target. Expert opinion: Autocrine production of NT-3 represents a selective advanta... mTOR inhibition in breast cancer: unraveling the complex mechanisms of mTOR signal transduction and its clinical implications in therapy [作者：O'Regan, R; Hawk, NN,期刊：Expert Opinion on Therapeutic Targets, 页码：859-872 , 文章类型： Review，,卷期：2011年15-7] Areas covered: This review describes how dysregulation of the mTOR pathway in breast cancer may contribute to breast cancer pathogenesis, as well as discussing preclinical and clinical data that support mTOR inhibitor th... Targeting the Wnt/beta beta-catenin signaling pathway in human cancers [作者：Yao, H; Ashihara, E; Maekawa, T,期刊：Expert Opinion on Therapeutic Targets, 页码：873-887 , 文章类型： Review，,卷期：2011年15-7] Areas covered: This review discusses the potential of inhibiting the Wnt/beta beta-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. Expert... NK-1 as a melanoma target [作者：Munoz, M; Bernabeu-Wittel, J; Covenas, R,期刊：Expert Opinion on Therapeutic Targets, 页码：889-897 , 文章类型： Review，,卷期：2011年15-7] Areas covered: This review provides an overview of the underlying mechanism of action of the SP/NK-1 receptor system, and NK-1 receptor antagonists in human melanoma, over the last 7 years. Expert opinion: In stages III ... Bitter taste receptors as a target for bronchodilation [作者：Doggrell, SA,期刊：Expert Opinion on Therapeutic Targets, 页码：899-902 , 文章类型： Editorial Material，,卷期：2011年15-7] Despite the present treatments for asthma (beta beta(2)-adrenoceptor agonists, glucocorticoids, leukotriene receptor antagonists), many subjects with asthma have difficulty controlling it. Bitter taste receptors have rec...